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Nidogen-1 (NID-1), formerly known as entactin, is a protein that in humans is encoded by the NID1 gene. Both nidogen-1 and nidogen-2 are essential components of the basement membrane alongside other components such as type IV collagen, proteoglycans (heparan sulfate and glycosaminoglycans), laminin and fibronectin.
The analysis highlights Function, Clinical significance and Interactions as prominent areas in the source structure around Nidogen-1.
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Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
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The extracted context around Nidogen-1 shows recurring relationship patterns in the source. For example, Nidogen-1 → basement membrane, basement membrane organization, calcium ion binding, cell adhesion, cell periphery, cell-matrix adhesion, collagen binding, collagen-containing extracellular matrix, extracellular exosome, extracellular matrix, extracellular matrix binding, extracellular matrix disassembly, extracellular matrix organization, extracellular matrix structural constituent, extracellular region, extracellular space, glomerular basement membrane development, laminin binding, laminin-1 binding, positive regulation of cell-substrate adhesion Another extracted example is Nidogen-1 → canal of the cervix, dermis, efferent ductule, endothelial cell of lymphatic vessel, epididymis, epithelium of lens, external carotid artery, gastric mucosa, Gonadal ridge, internal carotid artery, left lung lobe, left uterine tube, lower lobe of lung, pericardium, placenta, pylorus, right lung, stromal cell of endometrium, subcutaneous adipose tissue, trophoblast cell. Use these groups to spot repeated connection types before inspecting the individual relationships.
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bp chr human band gene nid1 chromosome basement protein external mouse membrane location nidogen laminin entactin collagen function pdb uniprot
TTTA extracted 88 structured relationships around Nidogen-1. Examples in this analysis include Nidogen-1 → Aliases → NID1, NID, nidogen 1, entactin and Nidogen-1 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1NDX. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| Nidogen-1 | Aliases | NID1, NID, nidogen 1, entactin | 1.00 | infobox |
| Nidogen-1 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1NDX | 1.00 | infobox |
| Nidogen-1 | Band | 1q42.3 | 1.00 | infobox |
| Nidogen-1 | Band | 13 A1|13 5.26 cM | 1.00 | infobox |
| Nidogen-1 | Bgee | stromal cell of endometrium | 1.00 | infobox |
| Nidogen-1 | Bgee | gastric mucosa | 1.00 | infobox |
| Nidogen-1 | Bgee | lower lobe of lung | 1.00 | infobox |
| Nidogen-1 | Bgee | left uterine tube | 1.00 | infobox |
| Nidogen-1 | Bgee | right lung | 1.00 | infobox |
| Nidogen-1 | Bgee | pericardium | 1.00 | infobox |
| Nidogen-1 | Bgee | pylorus | 1.00 | infobox |
| Nidogen-1 | Bgee | canal of the cervix | 1.00 | infobox |
| Nidogen-1 | Bgee | placenta | 1.00 | infobox |
| Nidogen-1 | Bgee | subcutaneous adipose tissue | 1.00 | infobox |
| Nidogen-1 | Bgee | endothelial cell of lymphatic vessel | 1.00 | infobox |
| Nidogen-1 | Bgee | epithelium of lens | 1.00 | infobox |
| Nidogen-1 | Bgee | epididymis | 1.00 | infobox |
| Nidogen-1 | Bgee | external carotid artery | 1.00 | infobox |
| Nidogen-1 | Bgee | internal carotid artery | 1.00 | infobox |
| Nidogen-1 | Bgee | efferent ductule | 1.00 | infobox |
| Nidogen-1 | Bgee | left lung lobe | 1.00 | infobox |
| Nidogen-1 | Bgee | trophoblast cell | 1.00 | infobox |
| Nidogen-1 | Bgee | Gonadal ridge | 1.00 | infobox |
| Nidogen-1 | Bgee | dermis | 1.00 | infobox |
| Nidogen-1 | BioGPS | More reference expression data | 1.00 | infobox |
| Nidogen-1 | Chr. | Chromosome 1 (human) | 1.00 | infobox |
| Nidogen-1 | Chr. | Chromosome 13 (mouse) | 1.00 | infobox |
| Nidogen-1 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| Nidogen-1 | End | 236,065,109 bp | 1.00 | infobox |
| Nidogen-1 | End | 13,686,854 bp | 1.00 | infobox |
The concept neighborhoods around Nidogen-1 bring nearby vocabulary together. In this analysis, examples include Collagen, Laminin and Membrane. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For Nidogen-1, one of the stronger structural bridges in this analysis connects Nidogen-1 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around Nidogen-1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Clinical significance & Interactions, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — Nidogen-1 · EN edition · Analysis: TopicsToTalkAbout