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Nidogen-1: Function, Clinical significance & Interactions

Nidogen-1 (NID-1), formerly known as entactin, is a protein that in humans is encoded by the NID1 gene. Both nidogen-1 and nidogen-2 are essential components of the basement membrane alongside other components such as type IV collagen, proteoglycans (heparan sulfate and glycosaminoglycans), laminin and fibronectin.

Language: English [EN]
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Nidogen-1 topic overview

The analysis highlights Function, Clinical significance and Interactions as prominent areas in the source structure around Nidogen-1.

Related topics
17
Source areas
4
Connected nodes
21
Extracted relationships
88
Related term clusters
12
Bridge connections
21

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 9 topics
Function · 4 topics
Clinical significance · 2 topics
Interactions · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
NID1, NID, nidogen 1, entactin
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1NDX
Band
1q42.3 · 13 A1|13 5.26 cM
Bgee
stromal cell of endometrium · gastric mucosa · lower lobe of lung · left uterine tube · right lung
BioGPS
More reference expression data
Chr.
Chromosome 1 (human) · Chromosome 13 (mouse)

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Nidogen-1
6Nidogen · Basement membrane · Perlecan
7Protein · Gene · Nidogen-2
4Dandy–Walker malformation · Encephalocele · Protein-protein interaction

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Clinical significance

Interactions

For the semantics nerds

You can skip this section if you’re here for content ideas and keyword inspiration.

Advanced semantic analysis

How Nidogen-1 connects Entity context

The extracted context around Nidogen-1 shows recurring relationship patterns in the source. For example, Nidogen-1 → basement membrane, basement membrane organization, calcium ion binding, cell adhesion, cell periphery, cell-matrix adhesion, collagen binding, collagen-containing extracellular matrix, extracellular exosome, extracellular matrix, extracellular matrix binding, extracellular matrix disassembly, extracellular matrix organization, extracellular matrix structural constituent, extracellular region, extracellular space, glomerular basement membrane development, laminin binding, laminin-1 binding, positive regulation of cell-substrate adhesion Another extracted example is Nidogen-1 → canal of the cervix, dermis, efferent ductule, endothelial cell of lymphatic vessel, epididymis, epithelium of lens, external carotid artery, gastric mucosa, Gonadal ridge, internal carotid artery, left lung lobe, left uterine tube, lower lobe of lung, pericardium, placenta, pylorus, right lung, stromal cell of endometrium, subcutaneous adipose tissue, trophoblast cell. Use these groups to spot repeated connection types before inspecting the individual relationships.

Nidogen-1

Top relations

Gene ontology · 21
Nidogen-1 → basement membrane, basement membrane organization, calcium ion binding, cell adhesion, cell periphery, cell-matrix adhesion, collagen binding, collagen-containing extracellular matrix, extracellular exosome, extracellular matrix, extracellular matrix binding, extracellular matrix disassembly, extracellular matrix organization, extracellular matrix structural constituent, extracellular region, extracellular space, glomerular basement membrane development, laminin binding, laminin-1 binding, positive regulation of cell-substrate adhesion
Bgee · 20
Nidogen-1 → canal of the cervix, dermis, efferent ductule, endothelial cell of lymphatic vessel, epididymis, epithelium of lens, external carotid artery, gastric mucosa, Gonadal ridge, internal carotid artery, left lung lobe, left uterine tube, lower lobe of lung, pericardium, placenta, pylorus, right lung, stromal cell of endometrium, subcutaneous adipose tissue, trophoblast cell
RNA expression pattern · 20
Nidogen-1 → canal of the cervix, dermis, efferent ductule, endothelial cell of lymphatic vessel, epididymis, epithelium of lens, external carotid artery, gastric mucosa, Gonadal ridge, internal carotid artery, left lung lobe, left uterine tube, lower lobe of lung, pericardium, placenta, pylorus, right lung, stromal cell of endometrium, subcutaneous adipose tissue, trophoblast cell
Band · 2
Nidogen-1 → 13 A1|13 5.26 cM, 1q42.3
Chr. · 2
Nidogen-1 → Chromosome 1 (human), Chromosome 13 (mouse)
End · 2
Nidogen-1 → 13,686,854 bp, 236,065,109 bp
Aliases · 1
Nidogen-1 → NID1, NID, nidogen 1, entactin
Available structures · 1
Nidogen-1 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1NDX
BioGPS · 1
Nidogen-1 → More reference expression data
Databases · 1
Nidogen-1 → NCBI: entry; OMA: entry

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

bp chr human band gene nid1 chromosome basement protein external mouse membrane location nidogen laminin entactin collagen function pdb uniprot

Nidogen-1 relationships Subject–Predicate–Object triples

TTTA extracted 88 structured relationships around Nidogen-1. Examples in this analysis include Nidogen-1 → Aliases → NID1, NID, nidogen 1, entactin and Nidogen-1 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1NDX. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Nidogen-1AliasesNID1, NID, nidogen 1, entactin1.00infobox
Nidogen-1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1NDX1.00infobox
Nidogen-1Band1q42.31.00infobox
Nidogen-1Band13 A1|13 5.26 cM1.00infobox
Nidogen-1Bgeestromal cell of endometrium1.00infobox
Nidogen-1Bgeegastric mucosa1.00infobox
Nidogen-1Bgeelower lobe of lung1.00infobox
Nidogen-1Bgeeleft uterine tube1.00infobox
Nidogen-1Bgeeright lung1.00infobox
Nidogen-1Bgeepericardium1.00infobox
Nidogen-1Bgeepylorus1.00infobox
Nidogen-1Bgeecanal of the cervix1.00infobox
Nidogen-1Bgeeplacenta1.00infobox
Nidogen-1Bgeesubcutaneous adipose tissue1.00infobox
Nidogen-1Bgeeendothelial cell of lymphatic vessel1.00infobox
Nidogen-1Bgeeepithelium of lens1.00infobox
Nidogen-1Bgeeepididymis1.00infobox
Nidogen-1Bgeeexternal carotid artery1.00infobox
Nidogen-1Bgeeinternal carotid artery1.00infobox
Nidogen-1Bgeeefferent ductule1.00infobox
Nidogen-1Bgeeleft lung lobe1.00infobox
Nidogen-1Bgeetrophoblast cell1.00infobox
Nidogen-1BgeeGonadal ridge1.00infobox
Nidogen-1Bgeedermis1.00infobox
Nidogen-1BioGPSMore reference expression data1.00infobox
Nidogen-1Chr.Chromosome 1 (human)1.00infobox
Nidogen-1Chr.Chromosome 13 (mouse)1.00infobox
Nidogen-1DatabasesNCBI: entry; OMA: entry1.00infobox
Nidogen-1End236,065,109 bp1.00infobox
Nidogen-1End13,686,854 bp1.00infobox

Related concept clusters Related term clusters

The concept neighborhoods around Nidogen-1 bring nearby vocabulary together. In this analysis, examples include Collagen, Laminin and Membrane. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Nidogen-1
    • Collagen
    • Laminin
    • Membrane
    • P10493
    • Structural
    • Uniprot
    • Basement
    • Mouse
    • Protein
    • Gene
    • Nid1
    • Nidogen-2
  • nidogen-1
    • Collagen
    • Laminin
    • Membrane
    • P10493
    • Structural
    • Uniprot
    • Basement
    • Mouse
    • Protein
    • Gene
    • Nid1
    • Nidogen-2
  • gene
    • Location
    • Chromosome
    • Human
    • Nid1
    • A1
    • Bp
    • Chr
    • End
    • External
    • Function
    • Search
    • Mouse
  • basement membrane
    • Collagen
    • Laminin
    • Components
    • Membrane
    • Nidogen-2
    • Protein
    • Nidogen-1
    • A1
    • Cell
    • End
    • External
    • Extracellular
  • type iv collagen
    • Laminin
    • Membrane
    • Nidogen-2
    • Nidogen-1
    • A1
    • Cell
    • Components
    • End
    • External
    • Extracellular
    • Function
    • Matrix
  • laminin
    • Membrane
    • Nidogen-2
    • Nidogen-1
    • A1
    • Cell
    • End
    • External
    • Extracellular
    • Function
    • Matrix
    • P10493
    • Search
  • function
    • External
    • Search
    • Location
    • Nidogen
    • Chromosome
    • Gene
    • Human
    • Nid1
    • Bp
    • Chr
    • A1
    • Available
  • extracellular matrix
    • Matrix
    • Function
    • Interactions
    • Laminin
    • Membrane
    • P10493
    • Search
    • Structural
    • Uniprot
    • Location
    • Mouse
    • Nidogen

Connections between topic areas Semantic bridges

For Nidogen-1, one of the stronger structural bridges in this analysis connects Nidogen-1 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Nidogen-1 — Overview · splits 12 ⟂ 10
Nidogen-1 — Function · splits 17 ⟂ 5
Nidogen-1 — Clinical significance · splits 19 ⟂ 3
Nidogen-1 — Interactions · splits 19 ⟂ 3

Map overview Semantic statistics

Nidogen-1

Nodes22
Edges21
Triples88
Avg. degree1.91
Density0.090909
Components1

Source & methodology

TTTA analyzes the structure around Nidogen-1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Clinical significance & Interactions, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Nidogen-1 · EN edition · Analysis: TopicsToTalkAbout

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