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PLCB2: Function, Interactions & Overview

1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-2 is an enzyme that in humans is encoded by the PLCB2 gene.

Language: English [EN]
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PLCB2 topic overview

The analysis highlights Function, Interactions and Overview as prominent areas in the source structure around PLCB2.

Related topics
10
Source areas
3
Connected nodes
13
Extracted relationships
83
Concept neighborhoods
9
Bridge connections
13

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 5 topics
Interactions · 3 topics
Overview · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3.1.4.11
Aliases
PLCB2, PLC-beta-2, phospholipase C beta 2
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2FJU, 2ZKM
Band
15q15.1 · 2 E5|2 59.43 cM
Bgee
granulocyte · monocyte · spleen · blood · bone marrow cell
BioGPS
More reference expression data

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How PLCB2 connects Entity context

The extracted context around PLCB2 shows recurring relationship patterns in the source. For example, PLCB2 → activation of phospholipase C activity, calcium ion binding, cytoplasm, cytosol, G protein-coupled receptor signaling pathway, hydrolase activity, inositol phosphate metabolic process, inositol trisphosphate biosynthetic process, intracellular signal transduction, lipid catabolic process, lipid metabolism, metal ion binding, phosphatidylinositol phospholipase C activity, phosphatidylinositol-mediated signaling, phospholipase C activity, phospholipid metabolic process, phosphoric diester hydrolase activity, release of sequestered calcium ion into cytosol, sensory perception of bitter taste, signal transducer activity Another extracted example is PLCB2 → aortic valve, appendix, ascending aorta, blood, bone marrow cell, C1 segment, female urethra, granulocyte, lumbar subsegment of spinal cord, lymph node, male urethra, monocyte, right lung, spermatocyte, spleen, thymus, upper lobe of left lung. Use these groups to spot repeated connection types before inspecting the individual relationships.

PLCB2

Top relations

Gene ontology · 22
PLCB2 → activation of phospholipase C activity, calcium ion binding, cytoplasm, cytosol, G protein-coupled receptor signaling pathway, hydrolase activity, inositol phosphate metabolic process, inositol trisphosphate biosynthetic process, intracellular signal transduction, lipid catabolic process, lipid metabolism, metal ion binding, phosphatidylinositol phospholipase C activity, phosphatidylinositol-mediated signaling, phospholipase C activity, phospholipid metabolic process, phosphoric diester hydrolase activity, release of sequestered calcium ion into cytosol, sensory perception of bitter taste, signal transducer activity
Bgee · 17
PLCB2 → aortic valve, appendix, ascending aorta, blood, bone marrow cell, C1 segment, female urethra, granulocyte, lumbar subsegment of spinal cord, lymph node, male urethra, monocyte, right lung, spermatocyte, spleen, thymus, upper lobe of left lung
RNA expression pattern · 17
PLCB2 → aortic valve, appendix, ascending aorta, blood, bone marrow cell, C1 segment, female urethra, granulocyte, lumbar subsegment of spinal cord, lymph node, male urethra, monocyte, right lung, spermatocyte, spleen, thymus, upper lobe of left lung
Band · 2
PLCB2 → 15q15.1, 2 E5|2 59.43 cM
Chr. · 2
PLCB2 → Chromosome 15 (human), Chromosome 2 (mouse)
End · 2
PLCB2 → 118,558,919 bp, 40,307,935 bp
related to Interactions · 2
PLCB2 → MAP2K3, TRPM7
3.1.4.11 · 1
PLCB2 → ↗
Aliases · 1
PLCB2 → PLCB2, PLC-beta-2, phospholipase C beta 2
Available structures · 1
PLCB2 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2FJU, 2ZKM

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

bp gene chr human band chromosome 15 enzyme location phospholipase mouse function 5-bisphosphate search activity 307 935 end 40 e5

PLCB2 relationships Subject–Predicate–Object triples

TTTA extracted 83 structured relationships around PLCB2. Examples in this analysis include PLCB2 → 3.1.4.11 → ↗ and PLCB2 → Aliases → PLCB2, PLC-beta-2, phospholipase C beta 2. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
PLCB23.1.4.111.00infobox
PLCB2AliasesPLCB2, PLC-beta-2, phospholipase C beta 21.00infobox
PLCB2Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2FJU, 2ZKM1.00infobox
PLCB2Band15q15.11.00infobox
PLCB2Band2 E5|2 59.43 cM1.00infobox
PLCB2Bgeegranulocyte1.00infobox
PLCB2Bgeemonocyte1.00infobox
PLCB2Bgeespleen1.00infobox
PLCB2Bgeeblood1.00infobox
PLCB2Bgeebone marrow cell1.00infobox
PLCB2Bgeelymph node1.00infobox
PLCB2Bgeeappendix1.00infobox
PLCB2Bgeeupper lobe of left lung1.00infobox
PLCB2Bgeeright lung1.00infobox
PLCB2BgeeC1 segment1.00infobox
PLCB2Bgeethymus1.00infobox
PLCB2Bgeefemale urethra1.00infobox
PLCB2Bgeemale urethra1.00infobox
PLCB2Bgeelumbar subsegment of spinal cord1.00infobox
PLCB2Bgeespermatocyte1.00infobox
PLCB2Bgeeascending aorta1.00infobox
PLCB2Bgeeaortic valve1.00infobox
PLCB2BioGPSMore reference expression data1.00infobox
PLCB2Chr.Chromosome 15 (human)1.00infobox
PLCB2Chr.Chromosome 2 (mouse)1.00infobox
PLCB2DatabasesNCBI: entry; OMA: entry1.00infobox
PLCB2End40,307,935 bp1.00infobox
PLCB2End118,558,919 bp1.00infobox
PLCB2EnsemblENSG000001378411.00infobox
PLCB2Entrez53301.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around PLCB2 bring nearby vocabulary together. In this analysis, examples include Phospholipase, Search and Location. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • enzyme
    • Plcb2
    • Activity
    • Codes
    • Function
    • Gene
    • Inositol
    • Phosphatidylinositol
    • Phospholipase
    • Search
    • Location
    • Chromosome
    • Human
  • gene
    • Location
    • Chromosome
    • Human
    • Plcb2
    • Bp
    • Chr
    • Activity
    • Codes
    • E5
    • End
    • Function
    • Mouse
  • function
    • Activity
    • Codes
    • Phospholipase
    • Search
    • Location
    • Chromosome
    • Human
    • Interactions
    • Plcb2
    • Reading
    • References
    • Bp
  • PLCB2
    • Phospholipase
    • Search
    • Location
    • Reading
    • References
    • Calcium
    • E5
    • End
    • Inositol
    • Intracellular
    • Mouse
    • Phosphatidylinositol
  • plcb2
    • Phospholipase
    • Search
    • Location
    • Reading
    • References
    • Calcium
    • E5
    • End
    • Inositol
    • Intracellular
    • Mouse
    • Phosphatidylinositol
  • phospholipase c
    • Search
    • Location
    • Plcb2
    • Reading
    • References
    • Calcium
    • E5
    • End
    • Inositol
    • Intracellular
    • Mouse
    • Phosphatidylinositol
  • phosphatidylinositol 4,5-bisphosphate
    • Beta-2
    • Encoded
    • Enzyme
    • Humans
    • Phosphodiesterase
    • Inositol
    • Phosphatidylinositol
    • Phospholipase
    • Search
    • Transduction
    • Plcb2
    • Gene
  • inositol 1,4,5-trisphosphate
    • Phosphatidylinositol
    • Intracellular
    • Mouse
    • Phospholipase
    • Search
    • Transduction
    • Location
    • Plcb2

Connections between topic areas Semantic bridges

For PLCB2, one of the stronger structural bridges in this analysis connects PLCB2 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
PLCB2Function · splits 8 ⟂ 6
PLCB2Interactions · splits 10 ⟂ 4
PLCB2Overview · splits 11 ⟂ 3

Map overview Semantic statistics

PLCB2

Nodes14
Edges13
Triples83
Avg. degree1.86
Density0.142857
Components1

Source & methodology

TTTA analyzes the structure around PLCB2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Interactions & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — PLCB2 · EN edition · Analysis: TopicsToTalkAbout

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