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IGFBP7

Insulin-like growth factor-binding protein 7 is a protein that in humans is encoded by the IGFBP7 gene. The major function of the protein is the regulation of availability of insulin-like growth factors (IGFs) in tissue as well as in modulating IGF binding to its receptors. IGFBP7 binds to IGF with low affinity compared to IGFBPs 1-6. It also stimulates…

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Aliases
IGFBP7, AGM, FSTL2, IBP-7, IGFBP-7, IGFBP-7v, IGFBPRP1, MAC25, PSF, RAMSVPS, TAF, insulin like growth factor binding protein 7
Band
4q12 · 5|5 C3.3
Bgee
vena cava · renal medulla · saphenous vein · Epithelium of choroid plexus · pericardium
BioGPS
More reference expression data
Chr.
Chromosome 4 (human) · Chromosome 5 (mouse)
Databases
NCBI: entry; OMA: entry

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IGFBP7

Nodes20
Edges19
Triples123
Avg. degree1.9
Density0.1
Components1

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IGFBP7

Top relations

Gene ontology · 21
IGFBP7 → cell adhesion, cellular response to hormone stimulus, collagen-containing extracellular matrix, embryo implantation, endoplasmic reticulum lumen, extracellular exosome, extracellular matrix, extracellular matrix structural constituent, extracellular region, extracellular space, growth factor binding, insulin-like growth factor binding, negative regulation of cell population proliferation, post-translational protein modification, protein binding, regulation of cell growth, regulation of steroid biosynthetic process, response to cortisol, response to heat, response to organic cyclic compound
Bgee · 19
IGFBP7 → aortic valve, ascending aorta, carotid body, Descending thoracic aorta, Epithelium of choroid plexus, epithelium of lens, mesenteric lymph nodes, pericardium, proximal tubule, renal corpuscle, renal medulla, right coronary artery, right kidney, right lung, saphenous vein, superficial temporal artery, tunica media of zone of aorta, urethra, vena cava
RNA expression pattern · 19
IGFBP7 → aortic valve, ascending aorta, carotid body, Descending thoracic aorta, Epithelium of choroid plexus, epithelium of lens, mesenteric lymph nodes, pericardium, proximal tubule, renal corpuscle, renal medulla, right coronary artery, right kidney, right lung, saphenous vein, superficial temporal artery, tunica media of zone of aorta, urethra, vena cava
related to Learning and memory · 13
IGFBP7 → Alzheimer's, Blocking IGFBP7, DNA, Elevation, European Neuroscience Institute-Goettingen, Germany, IGF2, IGF2/IGFBP7, PTSD, Targeting IGFBP7, The, These, This
related to Structure · 12
IGFBP7 → Arginine, At, Glu-38, Glycine, Heparin, IGF-1, In, Phenylalanine, Structural, The, This, This Valine
related to Types · 11
IGFBP7 → ADAR, ADAR1, ADAR3, ADARs, ECS, Editing Complentary Sequence, Inosines, It, RNA, The, There
related to Interactions · 4
IGFBP7 → IGF-1, IGF1R, Insulin-like, VPS24
is a · 3
IGFBP7 → critical regulator of memory consolidation and might be used as biomarker for Alzheimer's disease, substrate for ADAR1 based on the expression spectrum of the editing enzyme, substrate for ADAR1 based on the expression spectrum of the editing enzyme.SitesThe pre-mRNA of this protein is edited at two positions
Band · 2
IGFBP7 → 4q12, 5|5 C3.3
Chr. · 2
IGFBP7 → Chromosome 4 (human), Chromosome 5 (mouse)

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Important terminology

editing protein growth binding bp rna human position sites region chr band site gene acid heparin insulin-like function regulation amino

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
IGFBP7AliasesIGFBP7, AGM, FSTL2, IBP-7, IGFBP-7, IGFBP-7v, IGFBPRP1, MAC25, PSF, RAMSVPS, TAF, insulin like growth factor binding protein 71.00infobox
IGFBP7Band4q121.00infobox
IGFBP7Band5|5 C3.31.00infobox
IGFBP7Bgeevena cava1.00infobox
IGFBP7Bgeerenal medulla1.00infobox
IGFBP7Bgeesaphenous vein1.00infobox
IGFBP7BgeeEpithelium of choroid plexus1.00infobox
IGFBP7Bgeepericardium1.00infobox
IGFBP7Bgeesuperficial temporal artery1.00infobox
IGFBP7BgeeDescending thoracic aorta1.00infobox
IGFBP7Bgeeright coronary artery1.00infobox
IGFBP7Bgeeurethra1.00infobox
IGFBP7Bgeeascending aorta1.00infobox
IGFBP7Bgeeaortic valve1.00infobox
IGFBP7Bgeeepithelium of lens1.00infobox
IGFBP7Bgeeright kidney1.00infobox
IGFBP7Bgeetunica media of zone of aorta1.00infobox
IGFBP7Bgeeproximal tubule1.00infobox
IGFBP7Bgeerenal corpuscle1.00infobox
IGFBP7Bgeecarotid body1.00infobox
IGFBP7Bgeeright lung1.00infobox
IGFBP7Bgeemesenteric lymph nodes1.00infobox
IGFBP7BioGPSMore reference expression data1.00infobox
IGFBP7Chr.Chromosome 4 (human)1.00infobox
IGFBP7Chr.Chromosome 5 (mouse)1.00infobox
IGFBP7DatabasesNCBI: entry; OMA: entry1.00infobox
IGFBP7End57,110,385 bp1.00infobox
IGFBP7End77,555,888 bp1.00infobox
IGFBP7EnsemblENSG000001634531.00infobox
IGFBP7Entrez34901.00infobox

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