Hill equation (biochemistry)

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Ion channel Gene product Transcription factors Activators Repressors

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Proportion of ligand-bound receptors

Receptor protein Dissociation constant Law of mass action Monod equation Gaddum

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Tissue response

IUPHAR EC 50 {\displaystyle {\text{EC}}_{50}}Probit model Logit model Spearman–Kärber method

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Overview

Biochemistry Pharmacology Ligand Macromolecule Concentration

14 related topics

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Hill coefficient

Reversible form

Reversible Hill equation

Relationship to the elasticity coefficients

Elasticity coefficient

Applications

Ion channel
Gene product
Transcription factors Transcription factor
Activators Activator (genetics)
Repressors Repressor

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Nodes45

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Avg. degree1.96

Density0.044444

Components1

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Important terminology

hill equation ligand binding displaystyle coefficient response doi 10 cooperative receptor pmid concentration theta protein cooperativity ce model form tissue

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
this were very useful before the widespread use of computers	instance of	while a slope less than one indicates negatively cooperative binding.Transformations of equations into linear forms	0.80	text
as they allowed researchers to determine parameters by fitting lines to data	instance of	while a slope less than one indicates negatively cooperative binding.Transformations of equations into linear forms	0.80	text
the probit model or logit model	instance of	regardless of its affinity.The Del-Castillo Katz model is used to relate the Hill equation to receptor activation by including a second equilibrium of the ligand-bound receptor…	0.80	text
or other methods such as the Spearman	instance of	regardless of its affinity.The Del-Castillo Katz model is used to relate the Hill equation to receptor activation by including a second equilibrium of the ligand-bound receptor…	0.80	text
Hill coefficient do not characterise the local behaviours of the s-shaped curves	instance of	see Cooperative binding.Global sensitivity measure	0.80	text

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Applications

Proportion of ligand-bound receptors

Tissue response

Overview

Key facts & relationships

Topics to explore

Overview

Proportion of ligand-bound receptors

Tissue response

Hill coefficient

Reversible form

Relationship to the elasticity coefficients

Applications

Advanced semantic analysis

Map overview Semantic statistics