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Adefovir

Adefovir is a prescription medicine used to treat (chronic) infections with hepatitis B virus. A prodrug form of adefovir was previously called bis-POM PMEA, with trade names Preveon and Hepsera. It is an orally administered nucleotide analog reverse-transcriptase inhibitor (ntRTI). It can be formulated as the pivoxil prodrug adefovir dipivoxil.

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
J05AF08 (WHO)
Bioavailability
59%
CAS Number
106941-25-7 N
ChEBI
CHEBI:2469 Y

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Mechanism of action

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Map overview Semantic statistics

Adefovir

Nodes17
Edges16
Triples60
Avg. degree1.88
Density0.117647
Components1

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Adefovir

Top relations

related to history · 22
Adefovir → Academy, Antonín Holý, Biochemistry, Czech Republic, December, Drug Administration, European Union, FDA, Food, Gilead Sciences, HBV, Hepsera, HIV, However, Institute, March, November, Organic Chemistry, Preveon, Sciences
related to Mechanism of action · 5
Adefovir → ALT, HBV, It, NRTI, The
Legal status · 4
Adefovir → AU: S4 (Prescription only), CA: ℞-only, UK: POM (Prescription only), US: ℞-only
related to Uses · 3
Adefovir → HIV, It, Trials
related to External links · 2
Adefovir → CID, PubChem
3D model (JSmol) · 1
Adefovir → Interactive image
AHFS/Drugs.com · 1
Adefovir → Monograph
ATC code · 1
Adefovir → J05AF08 (WHO)
Bioavailability · 1
Adefovir → 59%
CAS Number · 1
Adefovir → 106941-25-7 N

Important terminology Word statistics

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Important terminology

treatment hepatitis prodrug hiv hepsera dipivoxil name prescription trade names drug fda hbv approved used chronic virus form preveon pubchem

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Adefovir3D model (JSmol)Interactive image1.00infobox
AdefovirAHFS/Drugs.comMonograph1.00infobox
AdefovirATC codeJ05AF08 (WHO)1.00infobox
AdefovirBioavailability59%1.00infobox
AdefovirCAS Number106941-25-7 N1.00infobox
AdefovirChEBICHEBI:2469 Y1.00infobox
AdefovirChEMBLChEMBL484 Y1.00infobox
AdefovirChemSpider54252 Y1.00infobox
AdefovirCompTox Dashboard (EPA)DTXSID60462141.00infobox
AdefovirDrugBankDB00718 Y1.00infobox
AdefovirECHA InfoCard100.106.2351.00infobox
AdefovirElimination half-life7.5 hours1.00infobox
AdefovirExcretionUrine1.00infobox
AdefovirFormulaC8H12N5O4P1.00infobox
AdefovirKEGGD02768 Y1.00infobox
AdefovirLegal statusAU: S4 (Prescription only)1.00infobox
AdefovirLegal statusCA: ℞-only1.00infobox
AdefovirLegal statusUK: POM (Prescription only)1.00infobox
AdefovirLegal statusUS: ℞-only1.00infobox
AdefovirMolar mass273.189 g·mol−11.00infobox
AdefovirNIAID ChemDB0285951.00infobox
AdefovirPregnancy categoryAU: B31.00infobox
AdefovirProtein binding<4%1.00infobox
AdefovirPubChem CID601721.00infobox
AdefovirRoutes of administrationOral1.00infobox
AdefovirTrade namesHepsera1.00infobox
AdefovirUNII6GQP90I7981.00infobox
Adefoviris aprescription medicine used to treat0.90text

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