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Lamivudine: History & Applications

Lamivudine, commonly called 3TC, is an antiretroviral medication used to prevent and treat HIV/AIDS. It is also used to treat chronic hepatitis B when other options are not possible. It is effective against both HIV-1 and HIV-2. It is typically used in combination with other antiretrovirals such as zidovudine, dolutegravir, and abacavir. Lamivudine may…

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Lamivudine topic overview

The analysis highlights History and Applications as prominent areas in the source structure around Lamivudine.

Related topics
65
Source areas
7
Connected nodes
72
Extracted relationships
123
Concept neighborhoods
32
Bridge connections
72

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Side effects · 21 topics
Overview · 17 topics
Formulations · 7 topics
History · 7 topics
Mechanism of action · 6 topics
Resistance · 6 topics
Medical uses · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
J05AF05 (WHO)
Bioavailability
86%
CAS Number
134678-17-4 Y
ChEMBL
ChEMBL141 Y

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Medical uses

Resistance

Side effects

Mechanism of action

History

Formulations

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Lamivudine connects Entity context

The extracted context around Lamivudine shows recurring relationship patterns in the source. For example, Lamivudine → As, AZT, Bernard Belleau, DNA, Drug Administration, Essential Medicines, FDA, HIV, Inc, It, McGill University, Montreal-based IAF BioChem International, November, Paul Nguyen-Ba, Racemic BCH-189, Samples, The, US Food, When, World Health Organization's List Another extracted example is Lamivudine → Emory University, GlaxoSmithKline, GSK, HBV, HIV, In, In HIV, L180M, L80V/I, M184V, M184V/I, M204V/I/S, Other, Raymond Schinazi's, The, The COLATE, The HBV, V173L, YIDD, YMDD. Use these groups to spot repeated connection types before inspecting the individual relationships.

Lamivudine

Top relations

related to history · 22
Lamivudine → As, AZT, Bernard Belleau, DNA, Drug Administration, Essential Medicines, FDA, HIV, Inc, It, McGill University, Montreal-based IAF BioChem International, November, Paul Nguyen-Ba, Racemic BCH-189, Samples, The, US Food, When, World Health Organization's List
related to Resistance · 20
Lamivudine → Emory University, GlaxoSmithKline, GSK, HBV, HIV, In, In HIV, L180M, L80V/I, M184V, M184V/I, M204V/I/S, Other, Raymond Schinazi's, The, The COLATE, The HBV, V173L, YIDD, YMDD
related to Formulations · 17
Lamivudine → Abacavir/lamivudine, Abacavir/lamivudine/zidovudine, B3TC, BLamivudine, BZeffix, Dolutegravir/lamivudine, Doravirine/lamivudine/tenofovir, Epivir, GlaxoSmithKline, HIV, HIV3TC-HBV, HIVEpivir-HBV, Indonesia, Lamivudine/zidovudine, South Africa, UK, US
has effect · 15
Lamivudine → Autoimmune, CMV, Do, HBV-infected, HCV, HIV, Long-term, MAC, Minor, Mycobacterium, Patients, Pneumocystis, The, Use, YMDD
related to Medical uses · 8
Lamivudine → Despite, Epivir, Epivir HBV, HIV, HIV/AIDS, It, Long-term, YMDD
related to Mechanism of action · 7
Lamivudine → DNA, HIV, It, OH, Some, The, They
Legal status · 4
Lamivudine → CA: ℞-only, EU: Rx-only, UK: POM (Prescription only), US: ℞-only
3D model (JSmol) · 1
Lamivudine → Interactive image
AHFS/Drugs.com · 1
Lamivudine → Monograph
ATC code · 1
Lamivudine → J05AF05 (WHO)

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

hiv hepatitis used reverse transcriptase zidovudine side effects treatment virus resistance liver medication combination use viral include antiretroviral abacavir epivir

Lamivudine relationships Subject–Predicate–Object triples

TTTA extracted 123 structured relationships around Lamivudine. Examples in this analysis include Lamivudine → 3D model (JSmol) → Interactive image and Lamivudine → AHFS/Drugs.com → Monograph. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Lamivudine3D model (JSmol)Interactive image1.00infobox
LamivudineAHFS/Drugs.comMonograph1.00infobox
LamivudineATC codeJ05AF05 (WHO)1.00infobox
LamivudineBioavailability86%1.00infobox
LamivudineCAS Number134678-17-4 Y1.00infobox
LamivudineChEMBLChEMBL141 Y1.00infobox
LamivudineChemSpider66068 Y1.00infobox
LamivudineCompTox Dashboard (EPA)DTXSID70231941.00infobox
LamivudineDrugBankDB00709 Y1.00infobox
LamivudineECHA InfoCard100.132.2501.00infobox
LamivudineElimination half-life5 to 7 hours1.00infobox
LamivudineExcretionKidney (circa 70%)1.00infobox
LamivudineFormulaC8H11N3O3S1.00infobox
LamivudineKEGGD00353 Y1.00infobox
LamivudineLegal statusCA: ℞-only1.00infobox
LamivudineLegal statusUK: POM (Prescription only)1.00infobox
LamivudineLegal statusUS: ℞-only1.00infobox
LamivudineLegal statusEU: Rx-only1.00infobox
LamivudineLicense dataUS DailyMed: Lamivudine1.00infobox
LamivudineMedlinePlusa6960111.00infobox
LamivudineMolar mass229.25 g·mol−11.00infobox
LamivudineNIAID ChemDB0003881.00infobox
LamivudineOther names(−)-L-2′,3′-dideoxy-3′-thiacytidine1.00infobox
LamivudinePDB ligand3TC (PDBe, RCSB PDB)1.00infobox
LamivudinePregnancy categoryAU: B31.00infobox
LamivudineProtein bindingLess than 36%1.00infobox
LamivudinePubChem CID608251.00infobox
LamivudineRoutes of administrationBy mouth1.00infobox
LamivudineTrade namesEpivir, Epivir-HBV, Zeffix, others1.00infobox
LamivudineUNII2T8Q726O951.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Lamivudine bring nearby vocabulary together. In this analysis, examples include Hiv, Treatment and Hepatitis. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Lamivudine
    • Hiv
    • Treatment
    • Hepatitis
    • Zidovudine
    • Virus
    • Resistant
    • Use
    • Resistance
    • Used
    • Drugs
    • Epivir
    • Mouth
  • lamivudine
    • Hiv
    • Treatment
    • Hepatitis
    • Zidovudine
    • Virus
    • Resistant
    • Use
    • Resistance
    • Used
    • Drugs
    • Epivir
    • Mouth
  • hiv/aids
    • Lamivudine
    • Treatment
    • Reverse
    • Transcriptase
    • Hepatitis
    • Resistance
    • Virus
    • Drugs
    • Epivir
    • May
    • Medication
    • Resistant
  • hiv reverse transcriptase
    • Transcriptase
    • Lamivudine
    • Treatment
    • Virus
    • Reverse
    • Ymdd
    • Hepatitis
    • Resistance
    • Drugs
    • Epivir
    • May
    • Medication
  • hiv
    • Lamivudine
    • Treatment
    • Reverse
    • Transcriptase
    • Hepatitis
    • Resistance
    • Virus
    • Drugs
    • Epivir
    • May
    • Medication
    • Resistant
  • lamivudine/zidovudine
    • Abacavir
    • Hiv
    • Dolutegravir
    • Treatment
    • Combination
    • Hepatitis
    • Lamivudine
    • Zidovudine
    • Virus
    • Resistant
    • Use
    • Resistance
  • abacavir/lamivudine
    • Dolutegravir
    • Zidovudine
    • Hiv
    • Treatment
    • Hepatitis
    • Drugs
    • Epivir
    • Patients
    • Virus
    • Combination
    • Resistant
    • Use
  • abacavir/lamivudine/zidovudine
    • Dolutegravir
    • Abacavir
    • Zidovudine
    • Hiv
    • Treatment
    • Combination
    • Hepatitis
    • Drugs
    • Epivir
    • Lamivudine
    • Patients
    • Virus

Connections between topic areas Semantic bridges

For Lamivudine, one of the stronger structural bridges in this analysis connects Lamivudine with Side effects. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Lamivudine — Side effects · splits 51 ⟂ 22
Lamivudine — Overview · splits 55 ⟂ 18
Lamivudine — History · splits 65 ⟂ 8
Lamivudine — Formulations · splits 65 ⟂ 8
Lamivudine — Resistance · splits 66 ⟂ 7
Lamivudine — Mechanism of action · splits 66 ⟂ 7

Map overview Semantic statistics

Lamivudine

Nodes73
Edges72
Triples123
Avg. degree1.97
Density0.027397
Components1

Source & methodology

TTTA analyzes the structure around Lamivudine to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History & Applications, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Lamivudine · EN edition · Analysis: TopicsToTalkAbout

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