Find related topics. | Discover entities. | See connections. | Build a topical map.
Building topical map: Starting…
Glutamate decarboxylase: Role in pathology, Overview & Other anti-GAD-associated neurologic disorders
Glutamate decarboxylase or glutamic acid decarboxylase (GAD) is an enzyme that catalyzes the decarboxylation of glutamate to gamma-aminobutyric acid (GABA) and carbon dioxide (CO2). GAD uses pyridoxal-phosphate (PLP) as a cofactor. The reaction proceeds as follows:
Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.
More settings
Glutamate decarboxylase topic overview
The analysis highlights Role in pathology, Overview and Other anti-GAD-associated neurologic disorders as prominent areas in the source structure around Glutamate decarboxylase.
Related topics
59
Source areas
7
Connected nodes
66
Extracted relationships
51
Concept neighborhoods
20
Bridge connections
66
What this topic covers Research coverage
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Role in pathology · 25 topics
Overview · 23 topics
Other anti-GAD-associated neurologic disorders · 4 topics
Role of glutamate decarboxylase in other organisms · 3 topics
Structure and mechanism · 2 topics
Regulation of GAD65 and GAD67 · 1 topics
Role in the nervous system · 1 topics
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
Key facts & relationships
High-confidence facts extracted from structured source data. Use them as anchors for further research.
BRENDA
enzyme data
CAS no.
9024-58-2m
EC no.
4.1.1.15
ExPASy
NiceZyme view
Gene Ontology
AmiGO / QuickGO
KEGG
enzyme entry
Explore all related topics Closing gaps
A structured outline of related entities, concepts and subtopics. Open any item to build a new map centered on it.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
How Glutamate decarboxylase connects Entity context
Entity context groups extracted connections by relationship type. Counts show recurrence in the analyzed source; the examples are research signals, not claims about importance.
The extracted context around Glutamate decarboxylase shows recurring relationship patterns in the source. For example, Glutamate decarboxylase → Besides, Binding, C-terminus, Ca2, CaM, CAM-binding, CAM-independent GAD, CaMBD, Finally, GABA, GAD, In Citrus, In Saccharomyces, Interesting, It, Similarly, The C-terminus, This, Unlike, When GAD Another extracted example is Glutamate decarboxylase → Deficits, Expression Profiling Support GABA, Glutamate, June, Media, Overview, PDB, PDBe-KB, Q05329, Q99259, Schizophrenia, Schizophrenia Research Forum, UniProt, Wikimedia CommonsGenetics, Wiktionary-logo-en-v2. Use these groups to spot repeated connection types before inspecting the individual relationships.
Glutamate decarboxylase
Top relations
related to Role of glutamate decarboxylase in other organisms· 22
Glutamate decarboxylase → Besides, Binding, C-terminus, Ca2, CaM, CAM-binding, CAM-independent GAD, CaMBD, Finally, GABA, GAD, In Citrus, In Saccharomyces, Interesting, It, Similarly, The C-terminus, This, Unlike, When GAD
Relationships are represented as Subject → Predicate → Object triples. Confidence describes extraction strength, not the real-world importance of a relationship; lower-confidence rows may be contextual rather than explicit.
TTTA extracted 51 structured relationships around Glutamate decarboxylase. Examples in this analysis include Glutamate decarboxylase → BRENDA → enzyme data and Glutamate decarboxylase → CAS no. → 9024-58-2m. The table shows each extracted connection, where it came from and its confidence.
Subject
Predicate
Object
Confidence
Src
Glutamate decarboxylase
BRENDA
enzyme data
1.00
infobox
Glutamate decarboxylase
CAS no.
9024-58-2m
1.00
infobox
Glutamate decarboxylase
EC no.
4.1.1.15
1.00
infobox
Glutamate decarboxylase
ExPASy
NiceZyme view
1.00
infobox
Glutamate decarboxylase
Gene Ontology
AmiGO / QuickGO
1.00
infobox
Glutamate decarboxylase
KEGG
enzyme entry
1.00
infobox
Glutamate decarboxylase
MetaCyc
metabolic pathway
1.00
infobox
Glutamate decarboxylase
NCBI
proteins
1.00
infobox
Glutamate decarboxylase
PDB structures
RCSB PDB PDBe PDBsum
1.00
infobox
Glutamate decarboxylase
PMC
articles
1.00
infobox
Glutamate decarboxylase
PubMed
articles
1.00
infobox
Glutamate decarboxylase
Rhea
reactions
1.00
infobox
Glutamate decarboxylase
Search
SearchPMCarticlesPubMedarticlesNCBIproteins
1.00
infobox
No triples extracted yet.
Related concept clusters Concept neighborhoods
Concept neighborhoods group terms that sit near one another in the extracted graph. They are useful for discovering adjacent language and context, but proximity does not by itself imply a factual relationship.
The concept neighborhoods around Glutamate decarboxylase bring nearby vocabulary together. In this analysis, examples include Glutamate, Levels and Pdb. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
Glutamate decarboxylase
Glutamate
Levels
Pdb
Gaba
Ph
Plants
Schizophrenia
Cerebellar
Disease
Nervous
System
Via
glutamate decarboxylase
Glutamate
Glutamic
Acid
Levels
Pdb
Disease
Gaba
Nervous
Ph
System
Plants
Schizophrenia
gaba
Neurotransmission
Plp
Gad67
Gad65
Glutamate
Production
Gad
Also
Brain
Active
Function
Glutamic
glutamic acid decarboxylase
Glutamic
Glutamate
Acid
Decarboxylase
Enzyme
Gad
Pdb
Disease
Nervous
System
Plants
Schizophrenia
regulation of gad65 and gad67
Gad65
Gad67
Regulated
Diabetes
Also
Neurotransmission
Type
Plp
Active
Downregulation
Schizophrenia
Two
role of glutamate decarboxylase in other organisms
Glutamate
Glutamic
Acid
Levels
Pdb
Disease
Gaba
Nervous
Ph
System
Plants
Schizophrenia
glutamate
Levels
Pdb
Gaba
Ph
Plants
Schizophrenia
Cerebellar
Disease
Nervous
System
Via
Coli
gamma-aminobutyric acid
Glutamic
Decarboxylase
Enzyme
Gad
Gaba
Autoantibodies
Disease
Nervous
System
Function
Ph
Production
Connections between topic areas Semantic bridges
Semantic bridges connect parts of the graph that would otherwise be more separate. A bridge is a structural signal in this analysis, not a claim that the two topic areas are equivalent.
For Glutamate decarboxylase, one of the stronger structural bridges in this analysis connects Glutamate decarboxylase with Role in pathology. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
Min side: 3
Glutamate decarboxylase — Role in pathology· splits 41 ⟂ 26Glutamate decarboxylase — Overview· splits 43 ⟂ 24Glutamate decarboxylase — Other anti-GAD-associated neurologic disorders· splits 62 ⟂ 5Glutamate decarboxylase — Role of glutamate decarboxylase in other organisms· splits 63 ⟂ 4Glutamate decarboxylase — Structure and mechanism· splits 64 ⟂ 3
Map overview Semantic statistics
Number of nodes, edges, triples, density and central hubs. Use it to gauge the size and connectivity of the map.
Glutamate decarboxylase
Nodes67
Edges66
Triples51
Avg. degree1.97
Density0.029851
Components1
Source & methodology
TTTA analyzes the structure around Glutamate decarboxylase to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Role in pathology, Overview & Other anti-GAD-associated neurologic disorders, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
