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Glial cell line-derived neurotrophic factor: History & Art

Glial cell line-derived neurotrophic factor (GDNF) is a protein that, in humans, is encoded by the GDNF gene. GDNF is a small protein that potently promotes the survival of many types of neurons. It signals through GFRα receptors, particularly GFRα1. It is also responsible for the determination of spermatogonia into primary spermatocytes, i.e. it is…

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Glial cell line-derived neurotrophic factor topic overview

The analysis highlights History and Art as prominent areas in the source structure around Glial cell line-derived neurotrophic factor.

Related topics
55
Source areas
6
Connected nodes
61
Extracted relationships
123
Related term clusters
23
Bridge connections
61

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 25 topics
Clinical significance · 14 topics
Interactions · 6 topics
Overview · 6 topics
Structure · 3 topics
History · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
GDNF, ATF1, ATF2, HFB1-HSCR3, glial cell derived neurotrophic factor, ATF
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2V5E, 3FUB, 4UX8
Band
5p13.2 · 15|15 A1
Bgee
muscle of thigh · tibialis anterior muscle · deltoid muscle · Skeletal muscle tissue of biceps brachii · muscle layer of sigmoid colon
BioGPS
More reference expression data
Chr.
Chromosome 5 (human) · Chromosome 15 (mouse)

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Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

History

Structure

Function

Interactions

Clinical significance

For the semantics nerds

You can skip this section if you’re here for content ideas and keyword inspiration.

Advanced semantic analysis

How Glial cell line-derived neurotrophic factor connects Entity context

The extracted context around Glial cell line-derived neurotrophic factor shows recurring relationship patterns in the source. For example, Glial cell line-derived neurotrophic factor → adult locomotory behavior, axon guidance, branching involved in ureteric bud morphogenesis, chemoattractant activity involved in axon guidance, chemoattraction of axon, commissural neuron axon guidance, dorsal spinal cord development, embryonic organ development, enteric nervous system development, extracellular region, extracellular space, growth factor activity, intracellular anatomical structure, MAPK cascade, mesenchymal to epithelial transition involved in metanephros morphogenesis, metanephros development, mRNA stabilization, negative regulation of apoptotic process, negative regulation of extrinsic apoptotic signaling pathway in absence of ligand, negative regulation of neuron apoptotic process Another extracted example is Glial cell line-derived neurotrophic factor → Bowman's capsule, deltoid muscle, epithelium of small intestine, gastric mucosa, gastrocnemius muscle, genitourinary system, Gonadal ridge, Hindgut, inner muscle layer, medullary collecting duct, migratory enteric neural crest cell, mucosa of ileum, muscle layer of sigmoid colon, muscle of thigh, muscularis mucosae, quadriceps femoris muscle, renal corpuscle, Skeletal muscle tissue of biceps brachii, Skeletal muscle tissue of rectus abdominis, tibialis anterior muscle. Use these groups to spot repeated connection types before inspecting the individual relationships.

Glial cell line-derived neurotrophic factor

Top relations

Gene ontology · 49
Glial cell line-derived neurotrophic factor → adult locomotory behavior, axon guidance, branching involved in ureteric bud morphogenesis, chemoattractant activity involved in axon guidance, chemoattraction of axon, commissural neuron axon guidance, dorsal spinal cord development, embryonic organ development, enteric nervous system development, extracellular region, extracellular space, growth factor activity, intracellular anatomical structure, MAPK cascade, mesenchymal to epithelial transition involved in metanephros morphogenesis, metanephros development, mRNA stabilization, negative regulation of apoptotic process, negative regulation of extrinsic apoptotic signaling pathway in absence of ligand, negative regulation of neuron apoptotic process
Bgee · 20
Glial cell line-derived neurotrophic factor → Bowman's capsule, deltoid muscle, epithelium of small intestine, gastric mucosa, gastrocnemius muscle, genitourinary system, Gonadal ridge, Hindgut, inner muscle layer, medullary collecting duct, migratory enteric neural crest cell, mucosa of ileum, muscle layer of sigmoid colon, muscle of thigh, muscularis mucosae, quadriceps femoris muscle, renal corpuscle, Skeletal muscle tissue of biceps brachii, Skeletal muscle tissue of rectus abdominis, tibialis anterior muscle
RNA expression pattern · 20
Glial cell line-derived neurotrophic factor → Bowman's capsule, deltoid muscle, epithelium of small intestine, gastric mucosa, gastrocnemius muscle, genitourinary system, Gonadal ridge, Hindgut, inner muscle layer, medullary collecting duct, migratory enteric neural crest cell, mucosa of ileum, muscle layer of sigmoid colon, muscle of thigh, muscularis mucosae, quadriceps femoris muscle, renal corpuscle, Skeletal muscle tissue of biceps brachii, Skeletal muscle tissue of rectus abdominis, tibialis anterior muscle
related to Interactions · 11
Glial cell line-derived neurotrophic factor → FAK, Fyn, GDNF, GFLs, GFRA1, GFRα1, GFRα1 GPI-anchor, Glial, GPI-anchor, NCAM, RET
Band · 2
Glial cell line-derived neurotrophic factor → 15|15 A1, 5p13.2
Chr. · 2
Glial cell line-derived neurotrophic factor → Chromosome 15 (mouse), Chromosome 5 (human)
End · 2
Glial cell line-derived neurotrophic factor → 37,840,041 bp, 7,867,056 bp
Aliases · 1
Glial cell line-derived neurotrophic factor → GDNF, ATF1, ATF2, HFB1-HSCR3, glial cell derived neurotrophic factor, ATF
Available structures · 1
Glial cell line-derived neurotrophic factor → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2V5E, 3FUB, 4UX8
BioGPS · 1
Glial cell line-derived neurotrophic factor → More reference expression data

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gdnf protein gene gfrα1 receptor also cell bp ret parkinson's cells factor chr human band disease neurotrophic neurons chromosome spermatogonia

Glial cell line-derived neurotrophic factor relationships Subject–Predicate–Object triples

TTTA extracted 123 structured relationships around Glial cell line-derived neurotrophic factor. Examples in this analysis include Glial cell line-derived neurotrophic factor → Aliases → GDNF, ATF1, ATF2, HFB1-HSCR3, glial cell derived neurotrophic factor, ATF and Glial cell line-derived neurotrophic factor → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2V5E, 3FUB, 4UX8. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Glial cell line-derived neurotrophic factorAliasesGDNF, ATF1, ATF2, HFB1-HSCR3, glial cell derived neurotrophic factor, ATF1.00infobox
Glial cell line-derived neurotrophic factorAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2V5E, 3FUB, 4UX81.00infobox
Glial cell line-derived neurotrophic factorBand5p13.21.00infobox
Glial cell line-derived neurotrophic factorBand15|15 A11.00infobox
Glial cell line-derived neurotrophic factorBgeemuscle of thigh1.00infobox
Glial cell line-derived neurotrophic factorBgeetibialis anterior muscle1.00infobox
Glial cell line-derived neurotrophic factorBgeedeltoid muscle1.00infobox
Glial cell line-derived neurotrophic factorBgeeSkeletal muscle tissue of biceps brachii1.00infobox
Glial cell line-derived neurotrophic factorBgeemuscle layer of sigmoid colon1.00infobox
Glial cell line-derived neurotrophic factorBgeegastrocnemius muscle1.00infobox
Glial cell line-derived neurotrophic factorBgeeSkeletal muscle tissue of rectus abdominis1.00infobox
Glial cell line-derived neurotrophic factorBgeequadriceps femoris muscle1.00infobox
Glial cell line-derived neurotrophic factorBgeegastric mucosa1.00infobox
Glial cell line-derived neurotrophic factorBgeemucosa of ileum1.00infobox
Glial cell line-derived neurotrophic factorBgeemedullary collecting duct1.00infobox
Glial cell line-derived neurotrophic factorBgeeinner muscle layer1.00infobox
Glial cell line-derived neurotrophic factorBgeemuscularis mucosae1.00infobox
Glial cell line-derived neurotrophic factorBgeerenal corpuscle1.00infobox
Glial cell line-derived neurotrophic factorBgeeHindgut1.00infobox
Glial cell line-derived neurotrophic factorBgeeBowman's capsule1.00infobox
Glial cell line-derived neurotrophic factorBgeeepithelium of small intestine1.00infobox
Glial cell line-derived neurotrophic factorBgeemigratory enteric neural crest cell1.00infobox
Glial cell line-derived neurotrophic factorBgeegenitourinary system1.00infobox
Glial cell line-derived neurotrophic factorBgeeGonadal ridge1.00infobox
Glial cell line-derived neurotrophic factorBioGPSMore reference expression data1.00infobox
Glial cell line-derived neurotrophic factorChr.Chromosome 5 (human)1.00infobox
Glial cell line-derived neurotrophic factorChr.Chromosome 15 (mouse)1.00infobox
Glial cell line-derived neurotrophic factorDatabasesNCBI: entry; OMA: entry1.00infobox
Glial cell line-derived neurotrophic factorEnd37,840,041 bp1.00infobox
Glial cell line-derived neurotrophic factorEnd7,867,056 bp1.00infobox

Related concept clusters Related term clusters

The concept neighborhoods around Glial cell line-derived neurotrophic factor bring nearby vocabulary together. In this analysis, examples include Neurotrophic, Line-derived and Factor. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Glial cell line-derived neurotrophic factor
    • Neurotrophic
    • Line-derived
    • Factor
    • Glial
    • Spermatogonia
    • Gene
    • Ret
    • Formation
    • Location
    • Structure
    • Chromosome
    • Clinical
  • glial cell line-derived neurotrophic factor
    • Neurotrophic
    • Line-derived
    • Factor
    • Glial
    • Gene
    • Formation
    • Location
    • Structure
    • Chromosome
    • Human
    • Bp
    • Chr
  • gdnf family of ligands
    • Receptor
    • Gene
    • Protein
    • Also
    • Expression
    • Well
    • Neurotrophic
    • Cells
    • Gfrα1
    • Formation
    • Potently
    • Structure
  • gdnf family receptor alpha 1
    • Gfrα1
    • Receptor
    • Gene
    • Well
    • Protein
    • Also
    • Ret
    • Expression
    • Neurotrophic
    • Cells
    • Formation
    • Potently
  • gdnf family ligand
    • Receptor
    • Gene
    • Protein
    • Also
    • Expression
    • Well
    • Neurotrophic
    • Cells
    • Gfrα1
    • Formation
    • Potently
    • Structure
  • neural cell adhesion molecule
    • Factor
    • Glial
    • Neurotrophic
    • Line-derived
    • Formation
    • Location
    • Structure
    • Gene
    • Chromosome
    • Human
    • Bp
    • Chr
  • neurotrophic factor
    • Neurotrophic
    • Glial
    • Line-derived
    • Gene
    • Formation
    • Location
    • Structure
    • Chromosome
    • Human
    • Bp
    • Chr
    • Spermatogonia
  • structure
    • Formation
    • Location
    • Chromosome
    • Human
    • Bp
    • Chr
    • Factor
    • Cell
    • Spermatogonia
    • End
    • Gene
    • Band

Connections between topic areas Semantic bridges

For Glial cell line-derived neurotrophic factor, one of the stronger structural bridges in this analysis connects Glial cell line-derived neurotrophic factor with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Glial cell line-derived neurotrophic factor — Function · splits 36 ⟂ 26
Glial cell line-derived neurotrophic factor — Clinical significance · splits 47 ⟂ 15
Glial cell line-derived neurotrophic factor — Overview · splits 55 ⟂ 7
Glial cell line-derived neurotrophic factor — Interactions · splits 55 ⟂ 7
Glial cell line-derived neurotrophic factor — Structure · splits 58 ⟂ 4

Map overview Semantic statistics

Glial cell line-derived neurotrophic factor

Nodes62
Edges61
Triples123
Avg. degree1.97
Density0.032258
Components1

Source & methodology

TTTA analyzes the structure around Glial cell line-derived neurotrophic factor to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History & Art, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Glial cell line-derived neurotrophic factor · EN edition · Analysis: TopicsToTalkAbout

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