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GJB6: Function, Clinical significance & Overview

Gap junction beta-6 protein (GJB6), also known as connexin 30 (Cx30) — is a protein that in humans is encoded by the GJB6 gene. Connexin 30 (Cx30) is one of several gap junction proteins expressed in the inner ear. Mutations in gap junction genes have been found to lead to both syndromic and nonsyndromic deafness. Mutations in this gene are associated…

Language: English [EN]
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GJB6 topic overview

The analysis highlights Function, Clinical significance and Overview as prominent areas in the source structure around GJB6.

Related topics
20
Source areas
3
Connected nodes
23
Extracted relationships
60
Concept neighborhoods
10
Bridge connections
23

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 13 topics
Overview · 4 topics
Clinical significance · 3 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
GJB6, CX30, DFNA3, DFNA3B, DFNB1B, ECTD2, ED2, EDH, HED, HED2, gap junction protein beta 6
Band
13q12.11 · 14 C3|14 30.1 cM
Bgee
skin of arm · gums · gingival epithelium · human penis · vulva
BioGPS
n/a
Chr.
Chromosome 13 (human) · Chromosome 14 (mouse)
Databases
NCBI: entry; OMA: entry

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How GJB6 connects Entity context

The extracted context around GJB6 shows recurring relationship patterns in the source. For example, GJB6 → body of tongue, cerebellar cortex, deep cerebellar nuclei, gingival epithelium, gums, human penis, lumbar subsegment of spinal cord, mammillary body, medial vestibular nucleus, mucosa of pharynx, oral cavity, skin of arm, skin of hip, skin of thigh, stria vascularis, transitional epithelium of urinary bladder, utricle, vestibular membrane of cochlear duct, vestibular sensory epithelium, vulva Another extracted example is GJB6 → 13q12.11, 14 C3|14 30.1 cM. Use these groups to spot repeated connection types before inspecting the individual relationships.

GJB6

Top relations

Bgee · 20
GJB6 → body of tongue, cerebellar cortex, deep cerebellar nuclei, gingival epithelium, gums, human penis, lumbar subsegment of spinal cord, mammillary body, medial vestibular nucleus, mucosa of pharynx, oral cavity, skin of arm, skin of hip, skin of thigh, stria vascularis, transitional epithelium of urinary bladder, utricle, vestibular membrane of cochlear duct, vestibular sensory epithelium, vulva
RNA expression pattern · 20
GJB6 → body of tongue, cerebellar cortex, deep cerebellar nuclei, gingival epithelium, gums, human penis, lumbar subsegment of spinal cord, mammillary body, medial vestibular nucleus, mucosa of pharynx, oral cavity, skin of arm, skin of hip, skin of thigh, stria vascularis, transitional epithelium of urinary bladder, utricle, vestibular membrane of cochlear duct, vestibular sensory epithelium, vulva
Band · 2
GJB6 → 13q12.11, 14 C3|14 30.1 cM
Chr. · 2
GJB6 → Chromosome 13 (human), Chromosome 14 (mouse)
End · 2
GJB6 → 20,232,365 bp, 57,371,068 bp
Aliases · 1
GJB6 → GJB6, CX30, DFNA3, DFNA3B, DFNB1B, ECTD2, ED2, EDH, HED, HED2, gap junction protein beta 6
BioGPS · 1
GJB6 → n/a
Databases · 1
GJB6 → NCBI: entry; OMA: entry
Ensembl · 1
GJB6 → ENSG00000121742
Entrez · 1
GJB6 → 10804

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

cx30 connexin gap junction 30 found cx26 protein bp gene expression cells chr human band channels connexins cell mice mouse

GJB6 relationships Subject–Predicate–Object triples

TTTA extracted 60 structured relationships around GJB6. Examples in this analysis include GJB6 → Aliases → GJB6, CX30, DFNA3, DFNA3B, DFNB1B, ECTD2, ED2, EDH, HED, HED2, gap junction protein beta 6 and GJB6 → Band → 13q12.11. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
GJB6AliasesGJB6, CX30, DFNA3, DFNA3B, DFNB1B, ECTD2, ED2, EDH, HED, HED2, gap junction protein beta 61.00infobox
GJB6Band13q12.111.00infobox
GJB6Band14 C3|14 30.1 cM1.00infobox
GJB6Bgeeskin of arm1.00infobox
GJB6Bgeegums1.00infobox
GJB6Bgeegingival epithelium1.00infobox
GJB6Bgeehuman penis1.00infobox
GJB6Bgeevulva1.00infobox
GJB6Bgeemucosa of pharynx1.00infobox
GJB6Bgeeoral cavity1.00infobox
GJB6Bgeeskin of thigh1.00infobox
GJB6Bgeebody of tongue1.00infobox
GJB6Bgeeskin of hip1.00infobox
GJB6Bgeeutricle1.00infobox
GJB6Bgeestria vascularis1.00infobox
GJB6Bgeetransitional epithelium of urinary bladder1.00infobox
GJB6Bgeedeep cerebellar nuclei1.00infobox
GJB6Bgeevestibular membrane of cochlear duct1.00infobox
GJB6Bgeemammillary body1.00infobox
GJB6Bgeecerebellar cortex1.00infobox
GJB6Bgeevestibular sensory epithelium1.00infobox
GJB6Bgeelumbar subsegment of spinal cord1.00infobox
GJB6Bgeemedial vestibular nucleus1.00infobox
GJB6BioGPSn/a1.00infobox
GJB6Chr.Chromosome 13 (human)1.00infobox
GJB6Chr.Chromosome 14 (mouse)1.00infobox
GJB6DatabasesNCBI: entry; OMA: entry1.00infobox
GJB6End20,232,365 bp1.00infobox
GJB6End57,371,068 bp1.00infobox
GJB6EnsemblENSG000001217421.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around GJB6 bring nearby vocabulary together. In this analysis, examples include Gene, Location and Protein. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • connexin
    • Gap
    • Wakefulness
    • Junction
    • Expressed
    • Cells
    • Expression
    • Found
    • Gjb6
    • Cochlea
    • Play
    • Cx30
    • Gene
  • connexin 26
    • Gap
    • Wakefulness
    • Junction
    • Expressed
    • Cells
    • Expression
    • Found
    • Gjb6
    • Cochlea
    • Play
    • Cx30
    • Gene
  • hair cells
    • Channels
    • Gap
    • Hair
    • Null
    • Cochlea
    • Found
    • Junction
    • Mice
    • Connexin
    • Cell
    • Connexins
    • Expression
  • connexin 30
    • Gap
    • Wakefulness
    • Junction
    • Expressed
    • Cells
    • Expression
    • Found
    • Gjb6
    • Cochlea
    • Play
    • Cx30
    • Gene
  • protein
    • Location
    • Chromosome
    • Human
    • Bp
    • Chr
    • Levels
    • Neuronal
    • Expression
    • Band
    • Network
    • Play
    • Mouse
  • GJB6
    • Gene
    • Location
    • Protein
    • Chromosome
    • Human
    • Bp
    • Chr
    • Junction
    • Band
    • Expressed
    • Mouse
    • Sleep
  • gjb6
    • Gene
    • Location
    • Protein
    • Chromosome
    • Human
    • Bp
    • Chr
    • Junction
    • Band
    • Expressed
    • Mouse
    • Sleep
  • gene
    • Gjb6
    • Location
    • Chromosome
    • Human
    • Bp
    • Chr
    • Protein
    • Band
    • Mouse
    • Junction
    • Expressed
    • Sleep

Connections between topic areas Semantic bridges

For GJB6, one of the stronger structural bridges in this analysis connects GJB6 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
GJB6 — Function · splits 10 ⟂ 14
GJB6 — Overview · splits 19 ⟂ 5
GJB6 — Clinical significance · splits 20 ⟂ 4

Map overview Semantic statistics

GJB6

Nodes24
Edges23
Triples60
Avg. degree1.92
Density0.083333
Components1

Source & methodology

TTTA analyzes the structure around GJB6 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Clinical significance & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — GJB6 · EN edition · Analysis: TopicsToTalkAbout

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