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Exemestane: Community, Culture, Applications & Research

Exemestane, sold under the brand name Aromasin among others, is a medication used to treat breast cancer. It is a member of the class of antiestrogens known as aromatase inhibitors. Some breast cancers require estrogen to grow. Those cancers have estrogen receptors (ERs), and are called ER-positive. They may also be called estrogen-responsive…

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Exemestane topic overview

The analysis highlights Community, Culture, Applications and Research as prominent areas in the source structure around Exemestane.

Related topics
59
Source areas
10
Connected nodes
69
Extracted relationships
84
Concept neighborhoods
16
Bridge connections
69

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Pharmacology · 14 topics
Overview · 8 topics
Side effects · 8 topics
Society and culture · 8 topics
Interactions · 7 topics
Chemistry · 5 topics
Medical uses · 4 topics
Contraindications · 2 topics
Research · 2 topics
Overdose · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
L02BG06 (WHO)
Bioavailability
~60%[citation needed]
CAS Number
107868-30-4 Y
ChEBI
CHEBI:4953 N

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Medical uses

Contraindications

Side effects

Overdose

Interactions

Pharmacology

Chemistry

Society and culture

Research

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Exemestane connects Entity context

The extracted context around Exemestane shows recurring relationship patterns in the source. For example, Exemestane → AUC, Cmax, CYP3A4, Estrogens, It, Other, St John's Wort, The, While Another extracted example is Exemestane → Along, FSH, It, LH, Selective, The, World Anti-Doping Agency's. Use these groups to spot repeated connection types before inspecting the individual relationships.

Exemestane

Top relations

related to Interactions · 9
Exemestane → AUC, Cmax, CYP3A4, Estrogens, It, Other, St John's Wort, The, While
related to Performance enhancement · 7
Exemestane → Along, FSH, It, LH, Selective, The, World Anti-Doping Agency's
related to Chemistry · 5
Exemestane → DMSO, It, Like, Optical, Pure
related to Pharmacokinetics · 5
Exemestane → CYP3A4, Highest, Maximal, Of, The
related to Research · 5
Exemestane → III, Interim, Oral, Preliminary, TEAM
has effect · 4
Exemestane → An, Aromasin, Nausea, The
related to Pharmacodynamics · 4
Exemestane → Any, ER-positive, Estrogen, The
is a · 3
Exemestane → irreversible steroidal aromatase inactivator of type I, steroid that is structurally similar to 4-androstenedione, white to off-white powder that is soluble in DMSO to at least 20 mg/mL
Legal status · 2
Exemestane → UK: POM (Prescription only), US: ℞-only
related to Medical uses · 2
Exemestane → October, US FDA

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

estrogen aromatase breast women cancer also postmenopausal tamoxifen enzyme inhibitors therapy cancers cyp3a4 inhibitor aromasin adjuvant premenopausal treatment patients mg

Exemestane relationships Subject–Predicate–Object triples

TTTA extracted 84 structured relationships around Exemestane. Examples in this analysis include Exemestane → 3D model (JSmol) → Interactive image and Exemestane → AHFS/Drugs.com → Monograph. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Exemestane3D model (JSmol)Interactive image1.00infobox
ExemestaneAHFS/Drugs.comMonograph1.00infobox
ExemestaneATC codeL02BG06 (WHO)1.00infobox
ExemestaneBioavailability~60%[citation needed]1.00infobox
ExemestaneCAS Number107868-30-4 Y1.00infobox
ExemestaneChEBICHEBI:4953 N1.00infobox
ExemestaneChEMBLChEMBL1200374 Y1.00infobox
ExemestaneChemSpider54278 Y1.00infobox
ExemestaneCompTox Dashboard (EPA)DTXSID50230371.00infobox
ExemestaneDrug classAromatase inhibitor; Antiestrogen1.00infobox
ExemestaneDrugBankDB00990 Y1.00infobox
ExemestaneDuration of action4–5 days[citation needed]1.00infobox
ExemestaneECHA InfoCard100.171.1491.00infobox
ExemestaneElimination half-life24 hours1.00infobox
ExemestaneExcretionUrine and feces ~ 1:1 (mainly metabolites)1.00infobox
ExemestaneFormulaC20H24O21.00infobox
ExemestaneIUPHAR/BPS70731.00infobox
ExemestaneKEGGD00963 Y1.00infobox
ExemestaneLegal statusUK: POM (Prescription only)1.00infobox
ExemestaneLegal statusUS: ℞-only1.00infobox
ExemestaneMedlinePlusa6070061.00infobox
ExemestaneMetabolismLiver (CYP3A4, aldo-keto reductase)1.00infobox
ExemestaneMolar mass296.410 g·mol−11.00infobox
ExemestaneOther namesFCE-243041.00infobox
ExemestanePronunciation/ˌɛksəˈmɛˌsteɪn/ EK-sə-ME-stayn1.00infobox
ExemestaneProtein binding90%1.00infobox
ExemestanePubChem CID601981.00infobox
ExemestaneRoutes of administrationBy mouth1.00infobox
ExemestaneTrade namesAromasin1.00infobox
ExemestaneUNIINY22HMQ4BX1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Exemestane bring nearby vocabulary together. In this analysis, examples include Breast, Cancer and Women. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Exemestane
    • Breast
    • Cancer
    • Women
    • Tamoxifen
    • Aromatase
    • Treatment
    • Trial
    • Postmenopausal
    • Adjuvant
    • Compared
    • Inhibitor
    • Mg
  • exemestane
    • Breast
    • Cancer
    • Women
    • Tamoxifen
    • Aromatase
    • Treatment
    • Trial
    • Postmenopausal
    • Adjuvant
    • Compared
    • Inhibitor
    • Mg
  • breast cancer
    • Cancer
    • Women
    • Treatment
    • Exemestane
    • Postmenopausal
    • Tamoxifen
    • Adjuvant
    • Advanced
    • Indicated
    • Trial
    • Compared
    • Therapy
  • aromatase inhibitors
    • Inhibitors
    • Inhibitor
    • Enzyme
    • Women
    • Exemestane
    • Estrogen
    • Class
    • Premenopausal
    • Breast
    • Cancer
    • Known
    • Adjuvant
  • aromatase
    • Inhibitors
    • Inhibitor
    • Enzyme
    • Women
    • Exemestane
    • Estrogen
    • Class
    • Premenopausal
    • Breast
    • Cancer
    • Adjuvant
    • Drug
  • adjuvant
    • Treatment
    • Tamoxifen
    • Postmenopausal
    • Indicated
    • Women
    • Breast
    • Inhibitor
    • Mg
    • Trial
    • Cancer
    • Therapy
    • Name
  • estrogen
    • Exemestane
    • Women
    • Therapy
    • Following
    • Side
    • Adjuvant
    • Effect
    • Effects
    • Known
    • Premenopausal
    • Suppression
    • Used
  • cyp3a4
    • Liver
    • Inhibitor
    • Enzyme
    • Name
    • Hours
    • Indicated
    • Side
    • Urine
    • Adjuvant
    • Drug
    • Effect
    • Effects

Connections between topic areas Semantic bridges

For Exemestane, one of the stronger structural bridges in this analysis connects Exemestane with Pharmacology. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Exemestane — Pharmacology · splits 55 ⟂ 15
Exemestane — Overview · splits 61 ⟂ 9
Exemestane — Side effects · splits 61 ⟂ 9
Exemestane — Society and culture · splits 61 ⟂ 9
Exemestane — Interactions · splits 62 ⟂ 8
Exemestane — Chemistry · splits 64 ⟂ 6
Exemestane — Medical uses · splits 65 ⟂ 5
Exemestane — Contraindications · splits 67 ⟂ 3
Exemestane — Research · splits 67 ⟂ 3

Map overview Semantic statistics

Exemestane

Nodes70
Edges69
Triples84
Avg. degree1.97
Density0.028571
Components1

Source & methodology

TTTA analyzes the structure around Exemestane to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Community, Culture, Applications & Research, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Exemestane · EN edition · Analysis: TopicsToTalkAbout

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