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Emicizumab

Emicizumab, sold under the brand name Hemlibra, is a humanized bispecific monoclonal antibody for the treatment of haemophilia A, developed by Genentech and Chugai (both organizations are subsidiaries of Hoffmann-La Roche). Emicizumab is a bispecific factor IXa- and factor X-directed antibody.

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Pharmacology

Coagulation factor IXFactor XFactor VIIICoagulation cascade
4 related topics

Adverse effects

Injection site reactionsHeadacheArthralgia
3 related topics

Regulatory approvals

Breakthrough TherapyEuropean Medicines Agency
2 related topics

Medical uses

Indicated
1 related topics

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

AHFS/Drugs.com
Monograph
ATC code
B02BX06 (WHO)
CAS Number
1610943-06-0
ChemSpider
none
DrugBank
DB13923
Formula
C6434H9940N1724O2047S45

Topics to explore

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Overview

Medical uses

Adverse effects

Pharmacology

Research

Regulatory approvals

Advanced semantic analysis

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Map overview Semantic statistics

Emicizumab

Nodes28
Edges27
Triples49
Avg. degree1.93
Density0.071429
Components1

How this topic connects Entity context

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Emicizumab

Top relations

related to Regulatory approvals · 8
Emicizumab → Breakthrough Therapy, FDA, HAVEN, Hemlibra, November, On October, This, VIII
related to Mechanism of action · 7
Emicizumab → FIXa, FVIIIa, FX, IX, This, Unlike, VIII
Legal status · 5
Emicizumab → AU: S4 (Prescription only), CA: ℞-only / Schedule D, EU: Rx-only, In general: ℞ (Prescription only), US: ℞-only
is a · 2
Emicizumab → better therapy compared to the previous generations, bispecific factor IXa- and factor X-directed antibody.Emicizumab was first approved by the U.S
related to Additional HAVEN studies · 2
Emicizumab → HAVEN, The
related to Available forms · 2
Emicizumab → The, VIII
related to HAVEN clinical trial program · 2
Emicizumab → HAVEN, Phase III
related to Research · 2
Emicizumab → Phase, Studies
AHFS/Drugs.com · 1
Emicizumab → Monograph
ATC code · 1
Emicizumab → B02BX06 (WHO)

Important terminology Word statistics

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Important terminology

factor patients viii hemophilia inhibitors administration fda haven antibody prophylaxis approval therapy bispecific developed clinical trial compared drug subcutaneous studies

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
EmicizumabAHFS/Drugs.comMonograph1.00infobox
EmicizumabATC codeB02BX06 (WHO)1.00infobox
EmicizumabCAS Number1610943-06-01.00infobox
EmicizumabChemSpidernone1.00infobox
EmicizumabDrugBankDB139231.00infobox
EmicizumabFormulaC6434H9940N1724O2047S451.00infobox
EmicizumabKEGGD10821 Y1.00infobox
EmicizumabLegal statusAU: S4 (Prescription only)1.00infobox
EmicizumabLegal statusCA: ℞-only / Schedule D1.00infobox
EmicizumabLegal statusUS: ℞-only1.00infobox
EmicizumabLegal statusEU: Rx-only1.00infobox
EmicizumabLegal statusIn general: ℞ (Prescription only)1.00infobox
EmicizumabLicense dataUS DailyMed: Emicizumab1.00infobox
EmicizumabMedlinePlusa6220461.00infobox
EmicizumabMolar mass145639.02 g·mol−11.00infobox
EmicizumabOther namesACE910, RG6013, emicizumab-kxwh1.00infobox
EmicizumabPregnancy categoryAU: B21.00infobox
EmicizumabRoutes of administrationSubcutaneous1.00infobox
EmicizumabSourceHumanized1.00infobox
EmicizumabTargetActivated factor IX, factor X1.00infobox
EmicizumabTrade namesHemlibra1.00infobox
EmicizumabTypeWhole antibody1.00infobox
EmicizumabUNII7NL2E3F6K31.00infobox
Emicizumabis abispecific factor IXa- and factor X-directed antibody.Emicizumab was first approved by the U.S0.90text
Emicizumabis abetter therapy compared to the previous generations0.90text

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