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DNMT3L: Function, Interactions & Overview

DNA (cytosine-5)-methyltransferase 3-like is an enzyme that in humans is encoded by the DNMT3L gene.

Language: English [EN]
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DNMT3L topic overview

The analysis highlights Function, Interactions and Overview as prominent areas in the source structure around DNMT3L.

Related topics
11
Source areas
3
Connected nodes
14
Extracted relationships
85
Related term clusters
9
Bridge connections
14

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 7 topics
Interactions · 2 topics
Overview · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
DNMT3L, DNA methyltransferase 3 like
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2PV0, 2PVC, 2QRV, 4U7P, 4U7T
Band
21q22.3 · 10 C1|10 39.72 cM
Bgee
testicle · liver · right lobe of liver · human kidney · gonad
BioGPS
More reference expression data
Chr.
Chromosome 21 (human) · Chromosome 10 (mouse)

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Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Interactions

For the semantics nerds

You can skip this section if you’re here for content ideas and keyword inspiration.

Advanced semantic analysis

How DNMT3L connects Entity context

The extracted context around DNMT3L shows recurring relationship patterns in the source. For example, DNMT3L → cell differentiation, cytosol, DNA methylation, DNA methylation involved in gamete generation, DNA methylation on cytosine, DNA-binding transcription factor activity, RNA polymerase II-specific, enzyme activator activity, enzyme binding, enzyme regulator activity, ESC/E(Z) complex, male meiosis I, metal ion binding, negative regulation of DNA methylation, negative regulation of transcription, DNA-templated, nucleus, positive regulation of catalytic activity, positive regulation of DNA methylation, protein binding, regulation of catalytic activity, regulation of gene expression by genetic imprinting Another extracted example is DNMT3L → blastocyst, embryo, gonad, Gonadal ridge, granulocyte, human kidney, liver, lymph node, morula, mucosa of transverse colon, primary oocyte, renal cortex, right lobe of liver, secondary oocyte, spermatid, testicle, tonsil, transitional epithelium of urinary bladder, zygote. Use these groups to spot repeated connection types before inspecting the individual relationships.

DNMT3L

Top relations

Gene ontology · 23
DNMT3L → cell differentiation, cytosol, DNA methylation, DNA methylation involved in gamete generation, DNA methylation on cytosine, DNA-binding transcription factor activity, RNA polymerase II-specific, enzyme activator activity, enzyme binding, enzyme regulator activity, ESC/E(Z) complex, male meiosis I, metal ion binding, negative regulation of DNA methylation, negative regulation of transcription, DNA-templated, nucleus, positive regulation of catalytic activity, positive regulation of DNA methylation, protein binding, regulation of catalytic activity, regulation of gene expression by genetic imprinting
Bgee · 19
DNMT3L → blastocyst, embryo, gonad, Gonadal ridge, granulocyte, human kidney, liver, lymph node, morula, mucosa of transverse colon, primary oocyte, renal cortex, right lobe of liver, secondary oocyte, spermatid, testicle, tonsil, transitional epithelium of urinary bladder, zygote
RNA expression pattern · 19
DNMT3L → blastocyst, embryo, gonad, Gonadal ridge, granulocyte, human kidney, liver, lymph node, morula, mucosa of transverse colon, primary oocyte, renal cortex, right lobe of liver, secondary oocyte, spermatid, testicle, tonsil, transitional epithelium of urinary bladder, zygote
Band · 2
DNMT3L → 10 C1|10 39.72 cM, 21q22.3
Chr. · 2
DNMT3L → Chromosome 10 (mouse), Chromosome 21 (human)
End · 2
DNMT3L → 44,262,216 bp, 77,899,456 bp
Aliases · 1
DNMT3L → DNMT3L, DNA methyltransferase 3 like
Available structures · 1
DNMT3L → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2PV0, 2PVC, 2QRV, 4U7P, 4U7T
BioGPS · 1
DNMT3L → More reference expression data
Databases · 1
DNMT3L → NCBI: entry; OMA: entry

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

dna bp gene chr human band chromosome 21 protein methylation location function enzyme mouse methyltransferase search 262 216 end 44

DNMT3L relationships Subject–Predicate–Object triples

TTTA extracted 85 structured relationships around DNMT3L. Examples in this analysis include DNMT3L → Aliases → DNMT3L, DNA methyltransferase 3 like and DNMT3L → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2PV0, 2PVC, 2QRV, 4U7P, 4U7T. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
DNMT3LAliasesDNMT3L, DNA methyltransferase 3 like1.00infobox
DNMT3LAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2PV0, 2PVC, 2QRV, 4U7P, 4U7T1.00infobox
DNMT3LBand21q22.31.00infobox
DNMT3LBand10 C1|10 39.72 cM1.00infobox
DNMT3LBgeetesticle1.00infobox
DNMT3LBgeeliver1.00infobox
DNMT3LBgeeright lobe of liver1.00infobox
DNMT3LBgeehuman kidney1.00infobox
DNMT3LBgeegonad1.00infobox
DNMT3LBgeelymph node1.00infobox
DNMT3LBgeerenal cortex1.00infobox
DNMT3LBgeegranulocyte1.00infobox
DNMT3LBgeetonsil1.00infobox
DNMT3LBgeemucosa of transverse colon1.00infobox
DNMT3LBgeetransitional epithelium of urinary bladder1.00infobox
DNMT3LBgeeprimary oocyte1.00infobox
DNMT3LBgeeblastocyst1.00infobox
DNMT3LBgeezygote1.00infobox
DNMT3LBgeemorula1.00infobox
DNMT3LBgeesecondary oocyte1.00infobox
DNMT3LBgeeGonadal ridge1.00infobox
DNMT3LBgeespermatid1.00infobox
DNMT3LBgeeembryo1.00infobox
DNMT3LBioGPSMore reference expression data1.00infobox
DNMT3LChr.Chromosome 21 (human)1.00infobox
DNMT3LChr.Chromosome 10 (mouse)1.00infobox
DNMT3LDatabasesNCBI: entry; OMA: entry1.00infobox
DNMT3LEnd44,262,216 bp1.00infobox
DNMT3LEnd77,899,456 bp1.00infobox
DNMT3LEnsemblENSG000001421821.00infobox

Related concept clusters Related term clusters

The concept neighborhoods around DNMT3L bring nearby vocabulary together. In this analysis, examples include Enzyme, Gene and Search. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • DNMT3L
    • Enzyme
    • Gene
    • Search
    • Function
    • Location
    • Chromosome
    • Human
    • Bp
    • Chr
    • Encoded
    • Humans
    • Imprinting
  • dnmt3l
    • Enzyme
    • Gene
    • Search
    • Function
    • Location
    • Chromosome
    • Human
    • Bp
    • Chr
    • Encoded
    • Humans
    • Imprinting
  • dna methylation
    • Cytosine
    • Development
    • Genomic
    • Required
    • Gene
    • Protein
    • Function
    • Methylation
    • Methyltransferase
    • Dnmt3l
    • Activity
    • Enzyme
  • dna methyltransferases
    • Gene
    • Protein
    • Function
    • Methylation
    • Methyltransferase
    • Dnmt3l
    • Activity
    • Cytosine
    • Development
    • Enzyme
    • Genomic
    • Required
  • dna cytosine methyltransferase 3 alpha
    • Genomic
    • Methylation
    • Thought
    • Gene
    • Imprinting
    • Protein
    • Function
    • Methyltransferase
    • Dnmt3l
    • Development
    • End
    • Enzyme
  • enzyme
    • Dnmt3l
    • Encoded
    • Humans
    • Imprinting
    • Gene
    • Activity
    • Biological
    • C1
    • Cytosine
    • Development
    • End
    • Genomic
  • gene
    • Location
    • Chromosome
    • Human
    • Bp
    • Chr
    • C1
    • End
    • Mouse
    • Search
    • Function
    • Band
    • Protein
  • function
    • Activity
    • Search
    • Location
    • Methyltransferase
    • Chromosome
    • Human
    • Bp
    • Chr
    • Gene
    • Imprinting
    • Protein
    • Biological

Connections between topic areas Semantic bridges

For DNMT3L, one of the stronger structural bridges in this analysis connects DNMT3L with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
DNMT3L — Function · splits 7 ⟂ 8
DNMT3L — Overview · splits 12 ⟂ 3
DNMT3L — Interactions · splits 12 ⟂ 3

Map overview Semantic statistics

DNMT3L

Nodes15
Edges14
Triples85
Avg. degree1.87
Density0.133333
Components1

Source & methodology

TTTA analyzes the structure around DNMT3L to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Interactions & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — DNMT3L · EN edition · Analysis: TopicsToTalkAbout

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