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DnaA

DnaA is a protein that activates initiation of DNA replication in bacteria. Based on the Replicon Model, a positively active initiator molecule contacts with a particular spot on a circular chromosome called the replicator to start DNA replication. It is a replication initiation factor which promotes the unwinding of DNA at oriC. The DnaA proteins found…

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Chromosome
genome: 3.88 - 3.88 Mb
Domains
InterPro
Entrez
948217
Organism
Escherichia coli (str. K-12 substr. MG1655)
Orthologs
NCBI: entry; OMA: entry
RefSeq (Prot)
NP_418157.1

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Function

Synthesis

Regulation

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DnaA

Nodes37
Edges36
Triples105
Avg. degree1.95
Density0.054054
Components1

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DnaA

Top relations

related to Function · 22
DnaA → ADP, Although, AT, AT-rich, ATP, ATP-form, CA, DNA, DnaB, DnaC, DnaG, DUEs, III, It, Okazaki, RNA, Single-strand, SSBs, The, There
related to Regulation · 22
DnaA → ADP-form, ATP, ATP-form, DARS1, DARS2, DNA, DnaA-ATP, DnaA-reactivating, DnaN, Each, Escherichia, Hda, It, OriC, OriC DnaA, Regulation, Regulatory, RIDA, The, The ADP-form
related to DnaA protein structure · 19
DnaA → AAA, ADP, An, As, ATP, ATPase, Bacillus, C-terminal, C-terminus, DNA, Enterobacterial, Escherichia, It, IV, N-terminus, NMR, The, There, When
related to Autoregulation of DnaA protein synthesis · 16
DnaA → According, An, DNA, DnaA-box, DnaA-boxes, DnaA46, GATC, Hansen, In, Rasmussen, The, The DnaA, These, This, Ts, Two
related to DnaA mutants · 7
DnaA → CRT46, CRT83, DNA, In, K-12, PC2, The
related to External links · 4
DnaA → Bacteria, Medicine Medical Subject Headings, MeSH, National Library
related to Synthesis · 4
DnaA → In, RNA, This, When DnaA
Chromosome · 1
DnaA → genome: 3.88 - 3.88 Mb
Domains · 1
DnaA → InterPro
Entrez · 1
DnaA → 948217

Important terminology Word statistics

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Important terminology

dna replication binding oric sites initiation protein affinity dnaa-atp complexes region ihf cell low bind active within cycle proteins promoter

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
DnaAChromosomegenome: 3.88 - 3.88 Mb1.00infobox
DnaADomainsInterPro1.00infobox
DnaAEntrez9482171.00infobox
DnaAOrganismEscherichia coli (str. K-12 substr. MG1655)1.00infobox
DnaAOrthologsNCBI: entry; OMA: entry1.00infobox
DnaARefSeq (Prot)NP_418157.11.00infobox
DnaASearch forSearch forStructuresSwiss-modelDomainsInterPro1.00infobox
DnaAStructuresSwiss-model1.00infobox
DnaASymbolDnaA1.00infobox
DnaAUniProtP030041.00infobox
DnaAis aprotein that activates initiation of DNA replication in bacteria0.90text
DnaArelated to Autoregulation of DnaA protein synthesisThe0.60section

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