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DNA ligase 1: Recruitment and regulation, Function and mechanism & Role in damaged base repair

DNA ligase 1 also DNA ligase I, is an enzyme that in humans is encoded by the LIG1 gene. DNA ligase 1 is the only known eukaryotic DNA ligase involved in both DNA replication and repair, making it the most studied of the ligases.

Language: English [EN]
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DNA ligase 1 topic overview

The analysis highlights Recruitment and regulation, Function and mechanism and Role in damaged base repair as prominent areas in the source structure around DNA ligase 1.

Related topics
51
Source areas
6
Connected nodes
57
Extracted relationships
176
Concept neighborhoods
23
Bridge connections
57

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Recruitment and regulation · 15 topics
Function and mechanism · 14 topics
Role in damaged base repair · 10 topics
Overview · 7 topics
Clinical significance · 4 topics
Discovery · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

6.5.1.1
Aliases
LIG1, DNA ligase 1, LIGI, hLig1, IMD96
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1X9N
Band
19q13.33 · 7 A1|7 7.82 cM
Bgee
right uterine tube · ventricular zone · ganglionic eminence · sural nerve · mucosa of transverse colon
BioGPS
More reference expression data

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Discovery

Recruitment and regulation

Function and mechanism

Role in damaged base repair

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How DNA ligase 1 connects Entity context

The extracted context around DNA ligase 1 shows recurring relationship patterns in the source. For example, DNA ligase 1 → Activation, Although, Both, C-terminal, C-terminus, CDK, CKII, Cy, DBD, DNA, II, LIG1, Moreover, N-terminal, N-terminal DNA, N-terminus, NLS, NTase, OB, PCNA Another extracted example is DNA ligase 1 → anatomical structure morphogenesis, ATP binding, base-excision repair, cell cycle, cell division, cellular response to DNA damage stimulus, cytoplasm, DNA binding, DNA biosynthetic process, DNA ligase (ATP) activity, DNA ligase activity, DNA ligation, DNA ligation involved in DNA repair, DNA mismatch repair, DNA recombination, DNA repair, DNA replication, intracellular membrane-bounded organelle, lagging strand elongation, ligase activity. Use these groups to spot repeated connection types before inspecting the individual relationships.

DNA ligase 1

Top relations

related to Recruitment and regulation · 33
DNA ligase 1 → Activation, Although, Both, C-terminal, C-terminus, CDK, CKII, Cy, DBD, DNA, II, LIG1, Moreover, N-terminal, N-terminal DNA, N-terminus, NLS, NTase, OB, PCNA
Gene ontology · 29
DNA ligase 1 → anatomical structure morphogenesis, ATP binding, base-excision repair, cell cycle, cell division, cellular response to DNA damage stimulus, cytoplasm, DNA binding, DNA biosynthetic process, DNA ligase (ATP) activity, DNA ligase activity, DNA ligation, DNA ligation involved in DNA repair, DNA mismatch repair, DNA recombination, DNA repair, DNA replication, intracellular membrane-bounded organelle, lagging strand elongation, ligase activity
Bgee · 20
DNA ligase 1 → epiblast, fetal liver hematopoietic progenitor cell, ganglionic eminence, genital tubercle, gonad, granulocyte, inner renal medulla, left testis, maxillary prominence, mucosa of transverse colon, outer renal medulla, primitive streak, right testis, right uterine tube, somite, sural nerve, tail of embryo, testicle, ventricular zone, yolk sac
RNA expression pattern · 20
DNA ligase 1 → epiblast, fetal liver hematopoietic progenitor cell, ganglionic eminence, genital tubercle, gonad, granulocyte, inner renal medulla, left testis, maxillary prominence, mucosa of transverse colon, outer renal medulla, primitive streak, right testis, right uterine tube, somite, sural nerve, tail of embryo, testicle, ventricular zone, yolk sac
related to Role in damaged base repair · 17
DNA ligase 1 → AP, AP-endonuclease, BER, DNA, DNA Polymerase, First, III, In, In LP-BER, It, Ligase, LP-BER, N-glycosidic, SN-BER, SNBER, The, This
related to Clinical significance · 11
DNA ligase 1 → Chemical, Clinical, Defects, DNA, DNA-damaging, LIG1, Molecular, Mutations, Notably, The, There
related to Function and mechanism · 11
DNA ligase 1 → ATP, DNA, DNA's, During, Eukaryotic DNA, If, In, LIG1, Okazaki, RNA, S-phase
related to External links · 6
DNA ligase 1 → DNA, Overview, P18858, PDB, PDBe-KB, UniProt
Band · 2
DNA ligase 1 → 19q13.33, 7 A1|7 7.82 cM
Chr. · 2
DNA ligase 1 → Chromosome 19 (human), Chromosome 7 (mouse)

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

dna ligase repair replication bp lig1 human cell chr band known enzyme gene n-terminal nick chromosome 19 strand immunodeficiency catalytic

DNA ligase 1 relationships Subject–Predicate–Object triples

TTTA extracted 176 structured relationships around DNA ligase 1. Examples in this analysis include DNA ligase 1 → 6.5.1.1 → ↗ and DNA ligase 1 → Aliases → LIG1, DNA ligase 1, LIGI, hLig1, IMD96. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
DNA ligase 16.5.1.11.00infobox
DNA ligase 1AliasesLIG1, DNA ligase 1, LIGI, hLig1, IMD961.00infobox
DNA ligase 1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1X9N1.00infobox
DNA ligase 1Band19q13.331.00infobox
DNA ligase 1Band7 A1|7 7.82 cM1.00infobox
DNA ligase 1Bgeeright uterine tube1.00infobox
DNA ligase 1Bgeeventricular zone1.00infobox
DNA ligase 1Bgeeganglionic eminence1.00infobox
DNA ligase 1Bgeesural nerve1.00infobox
DNA ligase 1Bgeemucosa of transverse colon1.00infobox
DNA ligase 1Bgeeleft testis1.00infobox
DNA ligase 1Bgeegranulocyte1.00infobox
DNA ligase 1Bgeegonad1.00infobox
DNA ligase 1Bgeeright testis1.00infobox
DNA ligase 1Bgeetesticle1.00infobox
DNA ligase 1Bgeetail of embryo1.00infobox
DNA ligase 1Bgeegenital tubercle1.00infobox
DNA ligase 1Bgeeouter renal medulla1.00infobox
DNA ligase 1Bgeefetal liver hematopoietic progenitor cell1.00infobox
DNA ligase 1Bgeeinner renal medulla1.00infobox
DNA ligase 1Bgeeprimitive streak1.00infobox
DNA ligase 1Bgeeepiblast1.00infobox
DNA ligase 1Bgeesomite1.00infobox
DNA ligase 1Bgeeyolk sac1.00infobox
DNA ligase 1Bgeemaxillary prominence1.00infobox
DNA ligase 1BioGPSMore reference expression data1.00infobox
DNA ligase 1Chr.Chromosome 19 (human)1.00infobox
DNA ligase 1Chr.Chromosome 7 (mouse)1.00infobox
DNA ligase 1DatabasesNCBI: entry; OMA: entry1.00infobox
DNA ligase 1End48,170,603 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around DNA ligase 1 bring nearby vocabulary together. In this analysis, examples include Ligase, Repair and Replication. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • DNA ligase 1
    • Ligase
    • Repair
    • Replication
    • Known
    • Lig1
    • Enzyme
    • Nick
    • Shown
    • Base
    • Cycle
    • Polymerase
    • Strand
  • dna ligase 1
    • Ligase
    • Repair
    • Replication
    • Known
    • Lig1
    • Cell
    • Enzyme
    • Nick
    • Shown
    • Base
    • Cycle
    • Polymerase
  • enzyme
    • Lig1
    • Gene
    • Function
    • Location
    • Chromosome
    • Together
    • Bp
    • Chr
    • Human
    • Known
    • Repair
    • Involved
  • dna ligase
    • Ligase
    • Repair
    • Replication
    • Known
    • Lig1
    • Cell
    • Enzyme
    • Nick
    • Shown
    • Base
    • Cycle
    • Polymerase
  • dna replication
    • Ligase
    • Repair
    • Replication
    • Together
    • N-terminal
    • Known
    • Lig1
    • Enzyme
    • Nick
    • Base
    • Cycle
    • Polymerase
  • dna binding domain
    • Ligase
    • Repair
    • Replication
    • Known
    • Lig1
    • Enzyme
    • Nick
    • Base
    • Cycle
    • Polymerase
    • Strand
    • Together
  • proliferating cell nuclear antigen
    • Replication
    • Cycle
    • Mouse
    • Cells
    • Together
    • Human
    • Ligase
    • Eukaryotic
    • Function
    • Involved
    • Location
    • Chromosome
  • cell cycle
    • Replication
    • Cycle
    • Together
    • Mouse
    • Cells
    • Human
    • Eukaryotic
    • Function
    • Involved
    • Location
    • End
    • Gene

Connections between topic areas Semantic bridges

For DNA ligase 1, one of the stronger structural bridges in this analysis connects DNA ligase 1 with Recruitment and regulation. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
DNA ligase 1Recruitment and regulation · splits 42 ⟂ 16
DNA ligase 1Function and mechanism · splits 43 ⟂ 15
DNA ligase 1Role in damaged base repair · splits 47 ⟂ 11
DNA ligase 1Overview · splits 50 ⟂ 8
DNA ligase 1Clinical significance · splits 53 ⟂ 5

Map overview Semantic statistics

DNA ligase 1

Nodes58
Edges57
Triples176
Avg. degree1.97
Density0.034483
Components1

Source & methodology

TTTA analyzes the structure around DNA ligase 1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Recruitment and regulation, Function and mechanism & Role in damaged base repair, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — DNA ligase 1 · EN edition · Analysis: TopicsToTalkAbout

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