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Neuromyelitis optica spectrum disorder

Neuromyelitis optica spectrum disorders (NMOSD) are a spectrum of autoimmune diseases characterized by acute inflammation of the optic nerve (optic neuritis, ON) and the spinal cord (myelitis). Episodes of ON and myelitis can be simultaneous or successive. A relapsing disease course is common, especially in untreated patients.

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Diagnostic method
Symptoms, blood antibody titers, MRI
Differential diagnosis
Multiple sclerosis, various autoimmune disorders
Frequency
Up to 1 in 10,000
Medication
Eculizumab, ravulizumab, inebilizumab, satralizumab, rituximab, methylprednisolone, azathioprine, cellCept, mitoxantrone, methotrexate, intravenous immunoglobulin, cyclophosphamide
Other names
Neuromyelitis optica (NMO), Devic's disease, Devic's syndrome
Risk factors
Female sex, genetic factors

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Neuromyelitis optica spectrum disorder

Nodes180
Edges179
Triples32
Avg. degree1.99
Density0.011111
Components1

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Neuromyelitis optica spectrum disorder

Top relations

related to Evolution of diagnostic criteria · 9
Neuromyelitis optica spectrum disorder → AQP4, MOG, NMO, NMO-like, NMOSD, Since, Some, The, Therefore
related to Epidemiology · 7
Neuromyelitis optica spectrum disorder → Among, MS, NMO, NMOSD, Only, Prevalence, Unlike MS
Diagnostic method · 1
Neuromyelitis optica spectrum disorder → Symptoms, blood antibody titers, MRI
Differential diagnosis · 1
Neuromyelitis optica spectrum disorder → Multiple sclerosis, various autoimmune disorders
Frequency · 1
Neuromyelitis optica spectrum disorder → Up to 1 in 10,000
Medication · 1
Neuromyelitis optica spectrum disorder → Eculizumab, ravulizumab, inebilizumab, satralizumab, rituximab, methylprednisolone, azathioprine, cellCept, mitoxantrone, methotrexate, intravenous immunoglobulin, cyclophosphamide
Other names · 1
Neuromyelitis optica spectrum disorder → Neuromyelitis optica (NMO), Devic's disease, Devic's syndrome
Risk factors · 1
Neuromyelitis optica spectrum disorder → Female sex, genetic factors
Specialty · 1
Neuromyelitis optica spectrum disorder → Neurology, ophthalmology
Symptoms · 1
Neuromyelitis optica spectrum disorder → Vision loss, sensory loss, weakness, bladder dysfunction

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Important terminology

nmo nmosd patients ms spinal cases disease aqp4 myelitis optic brain cord lesions autoimmune diseases spectrum anti-aqp4 found autoantibodies diagnosis

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Neuromyelitis optica spectrum disorderDiagnostic methodSymptoms, blood antibody titers, MRI1.00infobox
Neuromyelitis optica spectrum disorderDifferential diagnosisMultiple sclerosis, various autoimmune disorders1.00infobox
Neuromyelitis optica spectrum disorderFrequencyUp to 1 in 10,0001.00infobox
Neuromyelitis optica spectrum disorderMedicationEculizumab, ravulizumab, inebilizumab, satralizumab, rituximab, methylprednisolone, azathioprine, cellCept, mitoxantrone, methotrexate, intravenous immunoglobulin, cyclophosphamide1.00infobox
Neuromyelitis optica spectrum disorderOther namesNeuromyelitis optica (NMO), Devic's disease, Devic's syndrome1.00infobox
Neuromyelitis optica spectrum disorderRisk factorsFemale sex, genetic factors1.00infobox
Neuromyelitis optica spectrum disorderSpecialtyNeurology, ophthalmology1.00infobox
Neuromyelitis optica spectrum disorderSymptomsVision loss, sensory loss, weakness, bladder dysfunction1.00infobox
Neuromyelitis optica spectrum disorderTypesAQP4-IgG-positive, MOG-IgG-positive (recurrent, monophasic)1.00infobox
Neuromyelitis optica spectrum disorderUsual onsetMedian: age 40 for AQP4-IgG, age 31 for MOG-IgG1.00infobox
the area postremainstance ofThere is broad consensus that AQP4/NMO-IgG initially enters the brain via BBB-deficient sites0.80text
where there is access to cerebrospinal fluidinstance ofThere is broad consensus that AQP4/NMO-IgG initially enters the brain via BBB-deficient sites0.80text

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