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Pemetrexed: Applications, Medical use & Mechanism of action

Pemetrexed, sold under the brand name Alimta among others, is a chemotherapy medication for the treatment of pleural mesothelioma and non-small cell lung cancer (NSCLC).

Language: English [EN]
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Pemetrexed topic overview

The analysis highlights Applications, Medical use and Mechanism of action as prominent areas in the source structure around Pemetrexed.

Related topics
24
Source areas
4
Connected nodes
28
Extracted relationships
60
Concept neighborhoods
16
Bridge connections
28

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Mechanism of action · 9 topics
Medical use · 9 topics
Overview · 5 topics
Drug interaction · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
L01BA04 (WHO)
Bioavailability
NA
CAS Number
137281-23-3 N
ChEMBL
ChEMBL225072 Y

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Medical use

Drug interaction

Mechanism of action

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Pemetrexed connects Entity context

The extracted context around Pemetrexed shows recurring relationship patterns in the source. For example, Pemetrexed → ABC, As, B12, It, MDR1, MRP-5, Orai3, The Another extracted example is Pemetrexed → By, DHFR, DNA, GARFT, It, RNA, TS. Use these groups to spot repeated connection types before inspecting the individual relationships.

Pemetrexed

Top relations

related to Drug interaction · 8
Pemetrexed → ABC, As, B12, It, MDR1, MRP-5, Orai3, The
related to Mechanism of action · 7
Pemetrexed → By, DHFR, DNA, GARFT, It, RNA, TS
related to Medical use · 6
Pemetrexed → Drug Administration, FDA, Food, In February, In September, NSCLC
Legal status · 4
Pemetrexed → AU: S4 (Prescription only), EU: Rx-only, UK: POM (Prescription only), US: ℞-only
related to Supplementation · 4
Pemetrexed → B12, In, It, Patients
related to External links · 3
Pemetrexed → National Cancer Institute, NCI Drug Dictionary, October
related to Research · 3
Pemetrexed → Activity, NSCLC, Phase III
KEGG · 2
Pemetrexed → as salt: D06503 Y, D07472 Y
3D model (JSmol) · 1
Pemetrexed → Interactive image
AHFS/Drugs.com · 1
Pemetrexed → Monograph

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

cancer cisplatin mesothelioma treatment lung medication drug acid carboplatin patients non-small cell nsclc use brand administration normal name alimta others

Pemetrexed relationships Subject–Predicate–Object triples

TTTA extracted 60 structured relationships around Pemetrexed. Examples in this analysis include Pemetrexed → 3D model (JSmol) → Interactive image and Pemetrexed → AHFS/Drugs.com → Monograph. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Pemetrexed3D model (JSmol)Interactive image1.00infobox
PemetrexedAHFS/Drugs.comMonograph1.00infobox
PemetrexedATC codeL01BA04 (WHO)1.00infobox
PemetrexedBioavailabilityNA1.00infobox
PemetrexedCAS Number137281-23-3 N1.00infobox
PemetrexedChEMBLChEMBL225072 Y1.00infobox
PemetrexedChemSpider393879 Y1.00infobox
PemetrexedCompTox Dashboard (EPA)DTXSID20483291.00infobox
PemetrexedDrugBankDB00642 Y1.00infobox
PemetrexedECHA InfoCard100.205.7351.00infobox
PemetrexedElimination half-life3.5 hours1.00infobox
PemetrexedExcretionKidney1.00infobox
PemetrexedFormulaC20H21N5O61.00infobox
PemetrexedKEGGD07472 Y1.00infobox
PemetrexedKEGGas salt: D06503 Y1.00infobox
PemetrexedLegal statusAU: S4 (Prescription only)1.00infobox
PemetrexedLegal statusUK: POM (Prescription only)1.00infobox
PemetrexedLegal statusUS: ℞-only1.00infobox
PemetrexedLegal statusEU: Rx-only1.00infobox
PemetrexedLicense dataUS DailyMed: Pemetrexed1.00infobox
PemetrexedMetabolismNegligible1.00infobox
PemetrexedMolar mass427.417 g·mol−11.00infobox
PemetrexedPregnancy categoryAU: D1.00infobox
PemetrexedProtein binding81%1.00infobox
PemetrexedPubChem CID1354108751.00infobox
PemetrexedRoutes of administrationIntravenous1.00infobox
PemetrexedTrade namesAlimta, Pemfexy, Ciambra, others1.00infobox
PemetrexedUNII04Q9AIZ7NO1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Pemetrexed bring nearby vocabulary together. In this analysis, examples include Cancer, Mesothelioma and Acid. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Pemetrexed
    • Cancer
    • Mesothelioma
    • Acid
    • Administration
    • Normal
    • Lung
    • Treatment
    • Cisplatin
    • B12
    • Drugs
    • Folic
    • Malignant
  • pemetrexed
    • Cancer
    • Mesothelioma
    • Acid
    • Administration
    • Normal
    • Lung
    • Treatment
    • Cisplatin
    • B12
    • Drugs
    • Folic
    • Malignant
  • mesothelioma
    • Malignant
    • Pleural
    • Patients
    • Pemetrexed
    • Treatment
    • Approved
    • B12
    • Fda
    • Folic
    • Name
    • Others
    • Recommended
  • food and drug administration
    • Administration
    • Drug
    • Cisplatin
    • Names
    • Alimta
    • Approved
    • B12
    • Brand
    • Drugs
    • Fda
    • February
    • Malignant
  • non-small cell lung cancer
    • Cell
    • Non-small
    • Lung
    • Treatment
    • First-line
    • Cancer
    • Combination
    • Nsclc
    • Pemetrexed
    • Cisplatin
    • Chemotherapy
    • Fda
  • carboplatin
    • Drug
    • Names
    • Drugs
    • February
    • First-line
    • Name
    • Others
    • Pemfexy
    • Recommended
    • Supplementation
    • Us
    • Acid
  • folic acid
    • Drugs
    • Folic
    • Supplementation
    • Normal
    • B12
    • Names
    • Recommended
    • Alimta
    • Brand
    • Chemotherapy
    • February
    • Name
  • drug interaction
    • Administration
    • Cisplatin
    • Names
    • Approved
    • Drugs
    • Fda
    • February
    • Malignant
    • Name
    • Others
    • Pemfexy
    • Pleural

Connections between topic areas Semantic bridges

For Pemetrexed, one of the stronger structural bridges in this analysis connects Pemetrexed with Medical use. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
PemetrexedMedical use · splits 19 ⟂ 10
PemetrexedMechanism of action · splits 19 ⟂ 10
PemetrexedOverview · splits 23 ⟂ 6

Map overview Semantic statistics

Pemetrexed

Nodes29
Edges28
Triples60
Avg. degree1.93
Density0.068966
Components1

Source & methodology

TTTA analyzes the structure around Pemetrexed to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Applications, Medical use & Mechanism of action, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Pemetrexed · EN edition · Analysis: TopicsToTalkAbout

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