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A chiral switch is a chiral drug that has already approved as racemate but has been re-developed as a single enantiomer.
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chiral drug switch switches drugs racemic single switching racemate enantiomer strategy distomer new evergreening approach studies enantiomers eutomer one may
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| Chiral switch | is a | chiral drug that has already approved as racemate but has been re-developed as a single enantiomer.The term chiral switching was introduced by Agranat and Caner in 1999 to descr… | 0.90 | text |
| pharmacodynamic | instance of | incorporating various factors | 0.80 | text |
| pharmacokinetic | instance of | incorporating various factors | 0.80 | text |
| toxicological profile of the enantiomers | instance of | incorporating various factors | 0.80 | text |
| enantiomer-enantiomer interaction potential | instance of | incorporating various factors | 0.80 | text |
| safety | instance of | incorporating various factors | 0.80 | text |
| efficacy | instance of | incorporating various factors | 0.80 | text |
| risk-benefit ratio | instance of | incorporating various factors | 0.80 | text |
| chiral inversion | instance of | incorporating various factors | 0.80 | text |
| distomer liability | instance of | incorporating various factors | 0.80 | text |
| physicochemical properties | instance of | incorporating various factors | 0.80 | text |
| cost of separation | instance of | incorporating various factors | 0.80 | text |
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