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Thrombomodulin (TM), CD141 or BDCA-3 is an integral membrane protein expressed on the surface of endothelial cells and serves as a cofactor for thrombin. It reduces blood coagulation by converting thrombin to an anticoagulant enzyme from a procoagulant enzyme. Thrombomodulin is also expressed on human mesothelial cell, monocyte and a dendritic cell subset.
Function, Genetics and structure & Interactions
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human bp thrombin chr band gene protein thbd chromosome 20 expressed cells bdca-3 surface location function also membrane mouse cofactor
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| Thrombomodulin | Aliases | THBD, AHUS6, BDCA3, CD141, THPH12, THRM, TM, thrombomodulin, BDCA-3 | 1.00 | infobox |
| Thrombomodulin | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1ADX, 1DQB, 1DX5, 1EGT, 1FGD, 1FGE, 1HLT, 1TMR, 1ZAQ, 2ADX, 3GIS | 1.00 | infobox |
| Thrombomodulin | Band | 20p11.21 | 1.00 | infobox |
| Thrombomodulin | Band | 2 G3|2 73.45 cM | 1.00 | infobox |
| Thrombomodulin | Bgee | gingival epithelium | 1.00 | infobox |
| Thrombomodulin | Bgee | vena cava | 1.00 | infobox |
| Thrombomodulin | Bgee | right lung | 1.00 | infobox |
| Thrombomodulin | Bgee | skin of hip | 1.00 | infobox |
| Thrombomodulin | Bgee | skin of abdomen | 1.00 | infobox |
| Thrombomodulin | Bgee | skin of thigh | 1.00 | infobox |
| Thrombomodulin | Bgee | periodontal fiber | 1.00 | infobox |
| Thrombomodulin | Bgee | lower lobe of lung | 1.00 | infobox |
| Thrombomodulin | Bgee | upper lobe of left lung | 1.00 | infobox |
| Thrombomodulin | Bgee | left coronary artery | 1.00 | infobox |
| Thrombomodulin | Bgee | right lung lobe | 1.00 | infobox |
| Thrombomodulin | Bgee | left lung | 1.00 | infobox |
| Thrombomodulin | Bgee | left lung lobe | 1.00 | infobox |
| Thrombomodulin | Bgee | calvaria | 1.00 | infobox |
| Thrombomodulin | Bgee | Gonadal ridge | 1.00 | infobox |
| Thrombomodulin | Bgee | ankle | 1.00 | infobox |
| Thrombomodulin | Bgee | aortic valve | 1.00 | infobox |
| Thrombomodulin | Bgee | ascending aorta | 1.00 | infobox |
| Thrombomodulin | Bgee | white adipose tissue | 1.00 | infobox |
| Thrombomodulin | Bgee | decidua | 1.00 | infobox |
| Thrombomodulin | BioGPS | More reference expression data | 1.00 | infobox |
| Thrombomodulin | Chr. | Chromosome 20 (human) | 1.00 | infobox |
| Thrombomodulin | Chr. | Chromosome 2 (mouse) | 1.00 | infobox |
| Thrombomodulin | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| Thrombomodulin | End | 23,049,672 bp | 1.00 | infobox |
| Thrombomodulin | End | 148,250,108 bp | 1.00 | infobox |
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