Research any topic before you write.

Find related topics. | Discover entities. | See connections. | Build a topical map.

Thrombomodulin

Thrombomodulin (TM), CD141 or BDCA-3 is an integral membrane protein expressed on the surface of endothelial cells and serves as a cofactor for thrombin. It reduces blood coagulation by converting thrombin to an anticoagulant enzyme from a procoagulant enzyme. Thrombomodulin is also expressed on human mesothelial cell, monocyte and a dendritic cell subset.

Function, Genetics and structure & Interactions

Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.

Research this topic

Explore the main themes, entities and connections around Thrombomodulin. Start with the topic map, then use the sections below for research and deeper semantic analysis.

Explore this topic

Start with a few of the strongest sections from the source topic. These are research directions, not a list of keywords you must use.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
THBD, AHUS6, BDCA3, CD141, THPH12, THRM, TM, thrombomodulin, BDCA-3
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1ADX, 1DQB, 1DX5, 1EGT, 1FGD, 1FGE, 1HLT, 1TMR, 1ZAQ, 2ADX, 3GIS
Band
20p11.21 · 2 G3|2 73.45 cM
Bgee
gingival epithelium · vena cava · right lung · skin of hip · skin of abdomen
BioGPS
More reference expression data
Chr.
Chromosome 20 (human) · Chromosome 2 (mouse)

Topics to explore

Browse the full topic structure. Each item opens a new analysis centered on that subject.

Overview

Genetics and structure

Function

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

Map overview Semantic statistics

Thrombomodulin

Nodes30
Edges29
Triples102
Avg. degree1.93
Density0.066667
Components1

How this topic connects Entity context

See the strongest relationship patterns around the current topic before diving into the raw triples.

Thrombomodulin

Top relations

Gene ontology · 23
Thrombomodulin → apicolateral plasma membrane, blood coagulation, calcium ion binding, cell surface, extracellular space, female pregnancy, hemostasis, integral component of membrane, integral component of plasma membrane, leukocyte migration, membrane, negative regulation of blood coagulation, negative regulation of fibrinolysis, negative regulation of platelet activation, plasma membrane, protein binding, response to cAMP, response to lipopolysaccharide, response to X-ray, signal transduction
Bgee · 20
Thrombomodulin → ankle, aortic valve, ascending aorta, calvaria, decidua, gingival epithelium, Gonadal ridge, left coronary artery, left lung, left lung lobe, lower lobe of lung, periodontal fiber, right lung, right lung lobe, skin of abdomen, skin of hip, skin of thigh, upper lobe of left lung, vena cava, white adipose tissue
RNA expression pattern · 20
Thrombomodulin → ankle, aortic valve, ascending aorta, calvaria, decidua, gingival epithelium, Gonadal ridge, left coronary artery, left lung, left lung lobe, lower lobe of lung, periodontal fiber, right lung, right lung lobe, skin of abdomen, skin of hip, skin of thigh, upper lobe of left lung, vena cava, white adipose tissue
related to Genetics and structure · 8
Thrombomodulin → C-type, CTLD, EGF-like, In, It, Serine/Threonine-rich, THBD, The
related to Function · 7
Thrombomodulin → B2, C3b, Mutations, TAFI, THBD, This, Thrombomodulin-bound
Band · 2
Thrombomodulin → 2 G3|2 73.45 cM, 20p11.21
Chr. · 2
Thrombomodulin → Chromosome 2 (mouse), Chromosome 20 (human)
End · 2
Thrombomodulin → 148,250,108 bp, 23,049,672 bp
Aliases · 1
Thrombomodulin → THBD, AHUS6, BDCA3, CD141, THPH12, THRM, TM, thrombomodulin, BDCA-3
Available structures · 1
Thrombomodulin → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1ADX, 1DQB, 1DX5, 1EGT, 1FGD, 1FGE, 1HLT, 1TMR, 1ZAQ, 2ADX, 3GIS

Important terminology Word statistics

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

human bp thrombin chr band gene protein thbd chromosome 20 expressed cells bdca-3 surface location function also membrane mouse cofactor

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
ThrombomodulinAliasesTHBD, AHUS6, BDCA3, CD141, THPH12, THRM, TM, thrombomodulin, BDCA-31.00infobox
ThrombomodulinAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1ADX, 1DQB, 1DX5, 1EGT, 1FGD, 1FGE, 1HLT, 1TMR, 1ZAQ, 2ADX, 3GIS1.00infobox
ThrombomodulinBand20p11.211.00infobox
ThrombomodulinBand2 G3|2 73.45 cM1.00infobox
ThrombomodulinBgeegingival epithelium1.00infobox
ThrombomodulinBgeevena cava1.00infobox
ThrombomodulinBgeeright lung1.00infobox
ThrombomodulinBgeeskin of hip1.00infobox
ThrombomodulinBgeeskin of abdomen1.00infobox
ThrombomodulinBgeeskin of thigh1.00infobox
ThrombomodulinBgeeperiodontal fiber1.00infobox
ThrombomodulinBgeelower lobe of lung1.00infobox
ThrombomodulinBgeeupper lobe of left lung1.00infobox
ThrombomodulinBgeeleft coronary artery1.00infobox
ThrombomodulinBgeeright lung lobe1.00infobox
ThrombomodulinBgeeleft lung1.00infobox
ThrombomodulinBgeeleft lung lobe1.00infobox
ThrombomodulinBgeecalvaria1.00infobox
ThrombomodulinBgeeGonadal ridge1.00infobox
ThrombomodulinBgeeankle1.00infobox
ThrombomodulinBgeeaortic valve1.00infobox
ThrombomodulinBgeeascending aorta1.00infobox
ThrombomodulinBgeewhite adipose tissue1.00infobox
ThrombomodulinBgeedecidua1.00infobox
ThrombomodulinBioGPSMore reference expression data1.00infobox
ThrombomodulinChr.Chromosome 20 (human)1.00infobox
ThrombomodulinChr.Chromosome 2 (mouse)1.00infobox
ThrombomodulinDatabasesNCBI: entry; OMA: entry1.00infobox
ThrombomodulinEnd23,049,672 bp1.00infobox
ThrombomodulinEnd148,250,108 bp1.00infobox

Related concept clusters Concept neighborhoods

These clusters group vocabulary that occurs around closely connected concepts in the source material.

    Connections between topic areas Semantic bridges

    Bridges can reveal useful research angles that are easy to miss in a flat list of related terms.

    Min side: 3
    For writers, content strategists, SEOs, marketers and creators — from quick topic research to advanced semantic analysis.