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CREB

CREB-TF (CREB, cAMP response element-binding protein) is a cellular transcription factor. It binds to certain DNA sequences called cAMP response elements (CRE), thereby increasing or decreasing the transcription of the genes. CREB was first described in 1987 as a cAMP-responsive transcription factor regulating the somatostatin gene.

Overview, Involvement in circadian rhythms & Subtypes

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Overview

Subtypes

Structure

Mechanism of action

Function in the brain

Disease linkage

Involvement in circadian rhythms

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Map overview Semantic statistics

CREB

Nodes77
Edges76
Triples138
Avg. degree1.97
Density0.025974
Components1

How this topic connects Entity context

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CREB

Top relations

related to References · 49
CREB → Bailey, Barco, Bleckmann, Cell, Cell Biol, Common, Company, Conkright, Del Vecchio, Disruption, Drosophila, Gau, Genet, Great Psychological Experiments, Induction, ISBN, Kandel, Kapfhammer, Kellendonk, Kern
related to Involvement in circadian rhythms · 19
CREB → Ca2, Calcium, CK2, Entrainment, Excitation, However, Light, NMDA, PER, Per1, Per2, PKA, PKC, Response Element, RHT, SCN, The, These, This
related to External links · 12
CREB → Cell Signall, Drosophila Cyclic-AMP, IPR001630Johannessen, Medicine Medical Subject Headings, MeSH, Moens, National Library, Pedersen Delghandi, Protein, The Interactive Fly, The Interactive FlyDrosophila Cyclic-AMP, What Turns CREB
related to Subtypes · 11
CREB → ATF4, CREB-like, CREB1, CREB2, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREB5, The
related to Structure · 10
CREB → Ca2, CRE, DNA, Hydrophobic, PKA, Serine, The, These, This, When
related to Mechanism of action · 9
CREB → Ca2, CBP, CRE, CREB-binding, Evidence, G-protein, The, The DNA, This
related to Disease linkage · 8
CREB → Abnormalities, CBP, CREB-binding, Disturbance, Huntington's, KID, Rubinstein, Taybi
related to Discovery of CREB involvement in circadian rhythms · 7
CREB → Experiments, Furthermore, Gunther Schutz, In, Michael Greenberg, SCN, Ser142
related to cAMP response element · 6
CREB → CRE, CREs, However, TGACGTCA-3, The, There
related to Function in the brain · 6
CREB → Aplysia, CREM, Drosophila, Flies, If CREB, There

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Important terminology

protein transcription response camp circadian genes also doi pmid brain cell light 10 clock long-term role element cre memory factor

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
cAMP or Ca2instance ofwhich leads to the production of a second messenger0.80text
CREBrelated to cAMP response elementThe0.60section
CREBrelated to cAMP response elementCRE0.60section
CREBrelated to cAMP response elementTGACGTCA-30.60section
CREBrelated to cAMP response elementThere0.60section
CREBrelated to cAMP response elementCREs0.60section
CREBrelated to cAMP response elementHowever0.60section
CREBrelated to Discovery of CREB involvement in circadian rhythmsMichael Greenberg0.60section
CREBrelated to Discovery of CREB involvement in circadian rhythmsIn0.60section
CREBrelated to Discovery of CREB involvement in circadian rhythmsSCN0.60section
CREBrelated to Discovery of CREB involvement in circadian rhythmsExperiments0.60section
CREBrelated to Discovery of CREB involvement in circadian rhythmsGunther Schutz0.60section

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