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Zonisamide

Zonisamide, sold under the brand name Zonegran among others, is a medication used to treat the symptoms of epilepsy and Parkinson's disease. Chemically it is a sulfonamide. It is most commonly used as an anti-seizure medication in patients with focal or generalized epilepsy.

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
N03AX15 (WHO)
Bioavailability
~100%
CAS Number
68291-97-4 Y
ChEBI
CHEBI:10127 Y

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Overview

Medical uses

Adverse effects

Mechanism of action

Pharmacokinetics

History

Research

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Zonisamide

Nodes65
Edges64
Triples90
Avg. degree1.97
Density0.030769
Components1

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Zonisamide

Top relations

related to history · 18
Zonisamide → Asia, China, Dainippon Pharmaceutical, Dainippon Sumitomo Pharma, Eisai, Eisai Co, Europe, Excegran It, Germany, In Europe, It, Japan, Ltd, Taiwan, United Kingdom, United States, Uno, Zonegran
related to Epilepsy · 10
Zonisamide → Australia, Europe, However, In, Japan, Lennox-Gastaut, South Korea, There, United Kingdom, United States
related to Mechanism of action · 6
Zonisamide → GABAergic, In, It, More, T-type, The
related to Parkinson's disease · 6
Zonisamide → In, In Japan, It, Japan, Parkinson's, PD
Legal status · 4
Zonisamide → AU: S4 (Prescription only), EU: Rx-only, UK: POM (Prescription only), US: ℞-only
related to Interactions · 3
Zonisamide → Additionally, CYP3A4, Wada
related to Metabolism · 3
Zonisamide → CYP3A4, CYP3A5, CYP3A7
3D model (JSmol) · 1
Zonisamide → Interactive image
AHFS/Drugs.com · 1
Zonisamide → Monograph
ATC code · 1
Zonisamide → N03AX15 (WHO)

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Important terminology

also epilepsy treatment united used medication states zonegran japan symptoms patients focal effects parkinson's disease cyp3a4 obesity metabolism approved europe

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Zonisamide3D model (JSmol)Interactive image1.00infobox
ZonisamideAHFS/Drugs.comMonograph1.00infobox
ZonisamideATC codeN03AX15 (WHO)1.00infobox
ZonisamideBioavailability~100%1.00infobox
ZonisamideCAS Number68291-97-4 Y1.00infobox
ZonisamideChEBICHEBI:10127 Y1.00infobox
ZonisamideChEMBLChEMBL750 Y1.00infobox
ZonisamideChemSpider5532 Y1.00infobox
ZonisamideCompTox Dashboard (EPA)DTXSID90460231.00infobox
ZonisamideDrugBankDB00909 Y1.00infobox
ZonisamideECHA InfoCard100.118.5261.00infobox
ZonisamideElimination half-life63 hours in plasma1.00infobox
ZonisamideExcretionKidney (62%); Faeces (3%)1.00infobox
ZonisamideFormulaC8H8N2O3S1.00infobox
ZonisamideIUPHAR/BPS70471.00infobox
ZonisamideKEGGD00538 Y1.00infobox
ZonisamideLegal statusAU: S4 (Prescription only)1.00infobox
ZonisamideLegal statusUK: POM (Prescription only)1.00infobox
ZonisamideLegal statusUS: ℞-only1.00infobox
ZonisamideLegal statusEU: Rx-only1.00infobox
ZonisamideLicense dataUS DailyMed: Zonisamide1.00infobox
ZonisamideMedlinePlusa6030081.00infobox
ZonisamideMelting point162 °C (324 °F)1.00infobox
ZonisamideMetabolismLiver through CYP3A41.00infobox
ZonisamideMolar mass212.22 g·mol−11.00infobox
ZonisamidePDB ligandZON (PDBe, RCSB PDB)1.00infobox
ZonisamidePregnancy categoryAU: D1.00infobox
ZonisamideProtein binding40%1.00infobox
ZonisamidePubChem CID57341.00infobox
ZonisamideRoutes of administrationBy mouth1.00infobox

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