Zonisamide

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Zonisamide topic overview

The analysis highlights History, Applications, Research and Regions as prominent areas in the source structure around Zonisamide.

Related topics: 57
Source areas: 7
Connected nodes: 64
Extracted relationships: 90
Concept neighborhoods: 14
Bridge connections: 64

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Adverse effects · 31 topics

Pharmacokinetics · 6 topics

Mechanism of action · 5 topics

Overview · 5 topics

Research · 4 topics

History · 3 topics

Medical uses · 3 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol): Interactive image
AHFS/Drugs.com: Monograph
ATC code: N03AX15 (WHO)
Bioavailability: ~100%
CAS Number: 68291-97-4 Y
ChEBI: CHEBI:10127 Y

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Medical uses

Absence Absence seizure
Lennox-Gastaut syndrome Lennox–Gastaut syndrome
Levodopa

Mechanism of action

Sodium Sodium ion channel
T-type calcium channels T-type calcium channel
GABAergic Gamma-aminobutyric acid
Glutamatergic Glutamate
Glycine receptors

Pharmacokinetics

History

Research

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Zonisamide connects Entity context

The extracted context around Zonisamide shows recurring relationship patterns in the source. For example, Zonisamide → Asia, China, Dainippon Pharmaceutical, Dainippon Sumitomo Pharma, Eisai, Eisai Co, Europe, Excegran It, Germany, In Europe, It, Japan, Ltd, Taiwan, United Kingdom, United States, Uno, Zonegran Another extracted example is Zonisamide → Australia, Europe, However, In, Japan, Lennox-Gastaut, South Korea, There, United Kingdom, United States. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

related to history · 18

Zonisamide → Asia, China, Dainippon Pharmaceutical, Dainippon Sumitomo Pharma, Eisai, Eisai Co, Europe, Excegran It, Germany, In Europe, It, Japan, Ltd, Taiwan, United Kingdom, United States, Uno, Zonegran

related to Epilepsy · 10

Zonisamide → Australia, Europe, However, In, Japan, Lennox-Gastaut, South Korea, There, United Kingdom, United States

related to Mechanism of action · 6

Zonisamide → GABAergic, In, It, More, T-type, The

related to Parkinson's disease · 6

Zonisamide → In, In Japan, It, Japan, Parkinson's, PD

Legal status · 4

Zonisamide → AU: S4 (Prescription only), EU: Rx-only, UK: POM (Prescription only), US: ℞-only

related to Interactions · 3

Zonisamide → Additionally, CYP3A4, Wada

related to Metabolism · 3

Zonisamide → CYP3A4, CYP3A5, CYP3A7

3D model (JSmol) · 1

Zonisamide → Interactive image

AHFS/Drugs.com · 1

Zonisamide → Monograph

ATC code · 1

Zonisamide → N03AX15 (WHO)

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

also epilepsy treatment united used medication states zonegran japan symptoms patients focal effects parkinson's disease cyp3a4 obesity metabolism approved europe

Zonisamide relationships Subject–Predicate–Object triples

TTTA extracted 90 structured relationships around Zonisamide. Examples in this analysis include Zonisamide → 3D model (JSmol) → Interactive image and Zonisamide → AHFS/Drugs.com → Monograph. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
Zonisamide	3D model (JSmol)	Interactive image	1.00	infobox
Zonisamide	AHFS/Drugs.com	Monograph	1.00	infobox
Zonisamide	ATC code	N03AX15 (WHO)	1.00	infobox
Zonisamide	Bioavailability	~100%	1.00	infobox
Zonisamide	CAS Number	68291-97-4 Y	1.00	infobox
Zonisamide	ChEBI	CHEBI:10127 Y	1.00	infobox
Zonisamide	ChEMBL	ChEMBL750 Y	1.00	infobox
Zonisamide	ChemSpider	5532 Y	1.00	infobox
Zonisamide	CompTox Dashboard (EPA)	DTXSID9046023	1.00	infobox
Zonisamide	DrugBank	DB00909 Y	1.00	infobox
Zonisamide	ECHA InfoCard	100.118.526	1.00	infobox
Zonisamide	Elimination half-life	63 hours in plasma	1.00	infobox
Zonisamide	Excretion	Kidney (62%); Faeces (3%)	1.00	infobox
Zonisamide	Formula	C8H8N2O3S	1.00	infobox
Zonisamide	IUPHAR/BPS	7047	1.00	infobox
Zonisamide	KEGG	D00538 Y	1.00	infobox
Zonisamide	Legal status	AU: S4 (Prescription only)	1.00	infobox
Zonisamide	Legal status	UK: POM (Prescription only)	1.00	infobox
Zonisamide	Legal status	US: ℞-only	1.00	infobox
Zonisamide	Legal status	EU: Rx-only	1.00	infobox
Zonisamide	License data	US DailyMed: Zonisamide	1.00	infobox
Zonisamide	MedlinePlus	a603008	1.00	infobox
Zonisamide	Melting point	162 °C (324 °F)	1.00	infobox
Zonisamide	Metabolism	Liver through CYP3A4	1.00	infobox
Zonisamide	Molar mass	212.22 g·mol−1	1.00	infobox
Zonisamide	PDB ligand	ZON (PDBe, RCSB PDB)	1.00	infobox
Zonisamide	Pregnancy category	AU: D	1.00	infobox
Zonisamide	Protein binding	40%	1.00	infobox
Zonisamide	PubChem CID	5734	1.00	infobox
Zonisamide	Routes of administration	By mouth	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Zonisamide bring nearby vocabulary together. In this analysis, examples include Treatment, Absorption and Cyp3a4. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

Zonisamide
- Treatment
- Absorption
- Cyp3a4
- Also
- Effects
- Symptoms
- Zonegran
- Used
- Epilepsy
- Adverse
- Bioavailability
- Metabolism
zonisamide
- Treatment
- Absorption
- Cyp3a4
- Also
- Effects
- Symptoms
- Zonegran
- Used
- Epilepsy
- Adverse
- Bioavailability
- Metabolism
epilepsy
- Focal
- Approved
- Patients
- Generalized
- Name
- Disease
- Medication
- Parkinson's
- Europe
- Zonegran
- Japan
- States
parkinson's disease
- Disease
- Parkinson's
- Name
- Approved
- Symptoms
- Zonegran
- Japan
- Epilepsy
- Adverse
- Bioavailability
- Metabolism
- Migraine
adverse effects
- Depression
- Effects
- Metabolism
- Cyp3a4
- Obesity
- Bioavailability
- Migraine
- Name
- Absorption
- Anhydrase
- Carbonic
- Disease
bioavailability
- Metabolism
- Migraine
- Name
- Cyp3a4
- Depression
- Disease
- May
- Obesity
- Parkinson's
- Approved
- Effects
- Europe
cyp3a4
- Metabolism
- Effects
- Migraine
- Name
- Depression
- Disease
- Obesity
- Parkinson's
- Approved
- Europe
- Focal
- Zonegran
medication
- Commonly
- Used
- Epilepsy
- Generalized
- Name
- Others
- Treat
- Disease
- Parkinson's
- Focal
- Patients
- Symptoms

Connections between topic areas Semantic bridges

For Zonisamide, one of the stronger structural bridges in this analysis connects Zonisamide with Adverse effects. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

Zonisamide — Adverse effects · splits 33 ⟂ 32

Zonisamide — Pharmacokinetics · splits 58 ⟂ 7

Zonisamide — Overview · splits 59 ⟂ 6

Zonisamide — Mechanism of action · splits 59 ⟂ 6

Zonisamide — Research · splits 60 ⟂ 5

Zonisamide — Medical uses · splits 61 ⟂ 4

Zonisamide — History · splits 61 ⟂ 4

Map overview Semantic statistics

Zonisamide

Nodes65

Edges64

Triples90

Avg. degree1.97

Density0.030769

Components1

Source & methodology

TTTA analyzes the structure around Zonisamide to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Applications, Research & Regions, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Zonisamide · EN edition · Analysis: TopicsToTalkAbout