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Ghrelin

Ghrelin (/ˈɡrɛlɪn/; or lenomorelin, INN) is a hormone primarily produced by enteroendocrine cells of the gastrointestinal tract, especially the stomach, and is also dubbed the "hunger hormone" because it increases the drive to eat. Blood levels of ghrelin are highest before meals when hungry, returning to lower levels after mealtimes. Ghrelin may help…

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Function and mechanism of action

16 related topics

Overview

23 related topics

Gene, transcription products, and structure

9 related topics

History and name

1 related topics

Key facts & relationships

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Aliases
GHRL, ghrelin, Ghrelin, ghrelin and obestatin prepropeptide, MTLRP
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1P7X,%%s2JSH, 2JSI, 2JSJ
Band
3p25.3 · 6 E3|6 52.84 cM
Bgee
cardia · body of stomach · pancreatic epithelial cell · fundus · bone marrow cell
BioGPS
n/a
Chr.
Chromosome 3 (human) · Chromosome 6 (mouse)

Topics to explore

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Overview

History and name

Gene, transcription products, and structure

Ghrelin cells

Function and mechanism of action

Blood levels

Ghrelin receptor

Locations of action

Role(s) in disease

Advanced semantic analysis

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Map overview Semantic statistics

Ghrelin

Nodes73
Edges72
Triples225
Avg. degree1.97
Density0.027397
Components1

How this topic connects Entity context

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Ghrelin

Top relations

Gene ontology · 74
Ghrelin → actin polymerization or depolymerization, adult feeding behavior, axon, cartilage development, cortisol secretion, cytoplasm, decidualization, dendrite development, endoplasmic reticulum lumen, energy homeostasis, excitatory postsynaptic potential, extracellular region, extracellular space, G protein-coupled receptor binding, G protein-coupled receptor signaling pathway, gastric acid secretion, gastric emptying, ghrelin receptor binding, glucose metabolic process, glutamatergic synapse
Bgee · 18
Ghrelin → blood, body of stomach, bone marrow cell, cardia, duodenum, embryo, epithelium of stomach, fundus, islet of Langerhans, migratory enteric neural crest cell, mucous cell of stomach, neural layer of retina, pancreatic ductal cell, pancreatic epithelial cell, pyloric antrum, spermatid, spermatocyte, testicle
RNA expression pattern · 18
Ghrelin → blood, body of stomach, bone marrow cell, cardia, duodenum, embryo, epithelium of stomach, fundus, islet of Langerhans, migratory enteric neural crest cell, mucous cell of stomach, neural layer of retina, pancreatic ductal cell, pancreatic epithelial cell, pyloric antrum, spermatid, spermatocyte, testicle
related to Gene, transcription products, and structure · 11
Ghrelin → C-ghrelin, Five, GHS-R, GOAT, In, It, O-acyltransferase, Obestatin, Side-chains, The, The GHRL
related to Function and mechanism of action · 8
Ghrelin → AgRP, At, ATP, Gastric-brain, Ghrelin-responsiveness, NPY, S6K1, The
related to Immune system · 8
Ghrelin → Additionally, GHSR1a, GOAT, IL-1β, IL-4, INF-γ, TGF-β, TNF-α
related to Alternative names · 7
Ghrelin → A-like, Epsilon, Gr, P/D, The, X-cell, X/A-like
related to Stress/ Hypothalamic-pituitary-adrenal (HPA) axis · 7
Ghrelin → ACTH, CRH, Ghrelin's, GHSR1A, HPA, PVN, Studies
related to Anorexia and obesity · 6
Ghrelin → However, In, Prader, There, Those, Willi
related to Blood levels · 5
Ghrelin → Blood, Both, Circulating, Serum, The

Important terminology Word statistics

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Important terminology

levels hormone also cells receptor energy function gastric gene food growth human bp increase chr band blood glucose weight produced

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
GhrelinAliasesGHRL, ghrelin, Ghrelin, ghrelin and obestatin prepropeptide, MTLRP1.00infobox
GhrelinAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1P7X,%%s2JSH, 2JSI, 2JSJ1.00infobox
GhrelinBand3p25.31.00infobox
GhrelinBand6 E3|6 52.84 cM1.00infobox
GhrelinBgeecardia1.00infobox
GhrelinBgeebody of stomach1.00infobox
GhrelinBgeepancreatic epithelial cell1.00infobox
GhrelinBgeefundus1.00infobox
GhrelinBgeebone marrow cell1.00infobox
GhrelinBgeepancreatic ductal cell1.00infobox
GhrelinBgeeislet of Langerhans1.00infobox
GhrelinBgeeduodenum1.00infobox
GhrelinBgeetesticle1.00infobox
GhrelinBgeeblood1.00infobox
GhrelinBgeeepithelium of stomach1.00infobox
GhrelinBgeepyloric antrum1.00infobox
GhrelinBgeemucous cell of stomach1.00infobox
GhrelinBgeeneural layer of retina1.00infobox
GhrelinBgeespermatid1.00infobox
GhrelinBgeeembryo1.00infobox
GhrelinBgeespermatocyte1.00infobox
GhrelinBgeemigratory enteric neural crest cell1.00infobox
GhrelinBioGPSn/a1.00infobox
GhrelinChr.Chromosome 3 (human)1.00infobox
GhrelinChr.Chromosome 6 (mouse)1.00infobox
GhrelinDatabasesNCBI: entry; OMA: entry1.00infobox
GhrelinEnd10,292,947 bp1.00infobox
GhrelinEnd113,696,841 bp1.00infobox
GhrelinEnsemblENSG000001570171.00infobox
GhrelinEntrez517381.00infobox

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