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V600E

V600E is a mutation of the BRAF gene in which valine (V) is substituted by glutamic acid (E) at amino acid 600. It is a driver mutation in a proportion of certain diagnoses, including melanoma, hairy cell leukemia, papillary thyroid carcinoma, colorectal cancer, non-small-cell lung cancer, Langerhans cell histiocytosis, Erdheim–Chester disease (a…

Overview & Clinical

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Overview

MutationBRAFGeneValineGlutamic acid
20 related topics

Clinical

VemurafenibEncorafenibDabrafenibFDA
4 related topics

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Clinical

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V600E

Nodes27
Edges26
Triples3
Avg. degree1.93
Density0.074074
Components1

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V600E

Top relations

related to Clinical · 2
V600E → FDA, Vemurafenib
is a · 1
V600E → mutation of the BRAF gene in which valine

Important terminology Word statistics

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Important terminology

braf mutation glutamic acid residue activation segment activate gene valine melanoma histiocytosis ameloblastoma phosphomimetic phosphorylation threonine serine glycine substituted amino

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
V600Eis amutation of the BRAF gene in which valine0.90text
V600Erelated to ClinicalVemurafenib0.60section
V600Erelated to ClinicalFDA0.60section

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