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Urate oxidase

In molecular biology, urate oxidase (UO), also known as uricase or factor-independent urate hydroxylase, is a metabolic enzyme found in nearly all species from bacteria to mammals, but is not expressed in humans, great apes, and certain New World monkeys, in which it exists as a pseudogene. It catalyzes the oxidation of uric acid to 5-hydroxyisourate:

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Aliases
UOX, UOXP, URICASE, Urate oxidase, urate oxidase (pseudogene)
Band
3 H2|3 72.09 cM
Chr.
Chromosome 3 (mouse)
Databases
NCBI: entry; OMA: entry
End
146,338,060 bp
Ensembl
ENSG00000240520

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Overview

Species distribution

Convergent evolution

Localization

Structure

Function

Inhibitors

Clinical significance

Medical uses

In legumes

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Map overview Semantic statistics

Urate oxidase

Nodes76
Edges75
Triples54
Avg. degree1.97
Density0.026316
Components1

How this topic connects Entity context

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Urate oxidase

Top relations

related to Function · 12
Urate oxidase → According, After, Arg, Gln, HIU, O2, OHCU, Oxygen, The, Urate, Without HIU, X-ray
related to Convergent evolution · 9
Urate oxidase → Besides, FAD, HpxO, HpyO, NAD, PuuD, These, UOX, Urate
related to Structure · 5
Urate oxidase → It, Sequence, The, UO, Urate
related to Clinical significance · 3
Urate oxidase → Genetically, It, Its
related to Medical uses · 3
Urate oxidase → FDA, PEGylated, Urate
related to Species distribution · 3
Urate oxidase → New World, This, Urate
related to Inhibitors · 2
Urate oxidase → Inhibition, Urate
Aliases · 1
Urate oxidase → UOX, UOXP, URICASE, Urate oxidase, urate oxidase (pseudogene)
Band · 1
Urate oxidase → 3 H2|3 72.09 cM
Chr. · 1
Urate oxidase → Chromosome 3 (mouse)

Important terminology Word statistics

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Important terminology

urate oxidase acid uric enzyme found humans also bp 5-hydroxyisourate species pseudogene mammals uox mouse uricase chr legumes pathway site

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Urate oxidaseAliasesUOX, UOXP, URICASE, Urate oxidase, urate oxidase (pseudogene)1.00infobox
Urate oxidaseBand3 H2|3 72.09 cM1.00infobox
Urate oxidaseChr.Chromosome 3 (mouse)1.00infobox
Urate oxidaseDatabasesNCBI: entry; OMA: entry1.00infobox
Urate oxidaseEnd146,338,060 bp1.00infobox
Urate oxidaseEnsemblENSG000002405201.00infobox
Urate oxidaseEntrez3910511.00infobox
Urate oxidaseExternal IDsMGI: 98907; GeneCards: UOX1.00infobox
Urate oxidaseGene location (Mouse)Gene location (Mouse)Chr.Chromosome 3 (mouse)Band3 H2|3 72.09 cMStart146,276,181 bpEnd146,338,060 bp1.00infobox
Urate oxidaseLocation (UCSC)n/a1.00infobox
Urate oxidaseOrthologsOrthologsDatabasesNCBI: entry; OMA: entrySpeciesHumanMouseEntrez39105122262EnsemblENSG00000240520ENSMUSG00000028186UniProtn aP25688RefSeq (mRNA)n/aNM_009474RefSeq (protein)n/aNP…1.00infobox
Urate oxidaseRefSeq (mRNA)n/a1.00infobox
Urate oxidaseRefSeq (protein)n/a1.00infobox
Urate oxidaseSpeciesHuman1.00infobox
Urate oxidaseUniProtn a1.00infobox
Urate oxidaseis ahomotetrameric enzyme containing four identical active sites situated at the interfaces between its four subunits0.90text

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