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Regulator of nonsense transcripts 1 (or Up-frameshift suppressor 1 homolog) is a protein that in humans is encoded by the UPF1 gene.
The analysis highlights Function, Interactions and Overview as prominent areas in the source structure around UPF1.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around UPF1 shows recurring relationship patterns in the source. For example, UPF1 → 3'-UTR-mediated mRNA destabilization, ATP binding, cell cycle phase transition, cellular response to interleukin-1, cellular response to lipopolysaccharide, chromatin, chromatin binding, cytoplasm, cytosol, DNA binding, DNA repair, DNA replication, dosage compensation by inactivation of X chromosome, exon-exon junction complex, helicase activity, histone mRNA catabolic process, hydrolase activity, metal ion binding, mRNA export from nucleus, nuclear-transcribed mRNA catabolic process Another extracted example is UPF1 → anterior pituitary, aortic valve, ascending aorta, granulocyte, lip, mucosa of transverse colon, muscle of thigh, neural layer of retina, olfactory zone of nasal mucosa, right hemisphere of cerebellum, right lobe of thyroid gland, right testis, right uterine tube, secondary oocyte, skin of leg, spermatocyte, stromal cell of endometrium, ventricular zone, yolk sac. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
bp gene chr human band chromosome 19 protein mrna location mouse junction function cytoplasm nucleus homolog rna helicase search activity
TTTA extracted 105 structured relationships around UPF1. Examples in this analysis include UPF1 → 5.6.2.3 → ↗ and UPF1 → Aliases → UPF1, HNORF1, RENT1, pNORF1, smg-2, RNA helicase and ATPase, UPF1 RNA helicase and ATPase, UTF. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| UPF1 | 5.6.2.3 | ↗ | 1.00 | infobox |
| UPF1 | 5.6.2.5 | ↗ | 1.00 | infobox |
| UPF1 | Aliases | UPF1, HNORF1, RENT1, pNORF1, smg-2, RNA helicase and ATPase, UPF1 RNA helicase and ATPase, UTF | 1.00 | infobox |
| UPF1 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2GJK, 2GK6, 2GK7, 2IYK, 2WJV, 2WJY, 2XZO, 2XZP | 1.00 | infobox |
| UPF1 | Band | 19p13.11 | 1.00 | infobox |
| UPF1 | Band | 8 B3.3|8 34.15 cM | 1.00 | infobox |
| UPF1 | Bgee | right hemisphere of cerebellum | 1.00 | infobox |
| UPF1 | Bgee | mucosa of transverse colon | 1.00 | infobox |
| UPF1 | Bgee | olfactory zone of nasal mucosa | 1.00 | infobox |
| UPF1 | Bgee | granulocyte | 1.00 | infobox |
| UPF1 | Bgee | skin of leg | 1.00 | infobox |
| UPF1 | Bgee | anterior pituitary | 1.00 | infobox |
| UPF1 | Bgee | right uterine tube | 1.00 | infobox |
| UPF1 | Bgee | right testis | 1.00 | infobox |
| UPF1 | Bgee | right lobe of thyroid gland | 1.00 | infobox |
| UPF1 | Bgee | stromal cell of endometrium | 1.00 | infobox |
| UPF1 | Bgee | spermatocyte | 1.00 | infobox |
| UPF1 | Bgee | aortic valve | 1.00 | infobox |
| UPF1 | Bgee | lip | 1.00 | infobox |
| UPF1 | Bgee | ascending aorta | 1.00 | infobox |
| UPF1 | Bgee | secondary oocyte | 1.00 | infobox |
| UPF1 | Bgee | ventricular zone | 1.00 | infobox |
| UPF1 | Bgee | yolk sac | 1.00 | infobox |
| UPF1 | Bgee | muscle of thigh | 1.00 | infobox |
| UPF1 | Bgee | neural layer of retina | 1.00 | infobox |
| UPF1 | BioGPS | More reference expression data | 1.00 | infobox |
| UPF1 | Chr. | Chromosome 19 (human) | 1.00 | infobox |
| UPF1 | Chr. | Chromosome 8 (mouse) | 1.00 | infobox |
| UPF1 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| UPF1 | End | 18,868,230 bp | 1.00 | infobox |
The concept neighborhoods around UPF1 bring nearby vocabulary together. In this analysis, examples include Activity, Function and Gene. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For UPF1, one of the stronger structural bridges in this analysis connects UPF1 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around UPF1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Interactions & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — UPF1 · EN edition · Analysis: TopicsToTalkAbout