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TNF receptor superfamily member 9, a member of the TNF receptor superfamily, is a type 1 transmembrane protein, expressed on surfaces of leukocytes and non-immune cells. Its alternative names are CD137, 4-1BB, and induced by lymphocyte activation (ILA). It is of interest to immunologists as a co-stimulatory immune checkpoint molecule, and as a potential…
The analysis highlights Expression, Atherosclerosis and Regulation of the immune system as prominent areas in the source structure around TNFRSF9.
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Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
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The extracted context around TNFRSF9 shows recurring relationship patterns in the source. For example, TNFRSF9 → apoptotic process, apoptotic signaling pathway, cytokine binding, external side of plasma membrane, extracellular space, immune response, inflammatory response, integral component of membrane, integral component of plasma membrane, membrane, multicellular organism development, negative regulation of cell population proliferation, plasma membrane, protein homotrimerization, regulation of apoptotic process, regulation of cell population proliferation, response to lipopolysaccharide, signaling receptor activity, tumor necrosis factor-activated receptor activity, tumor necrosis factor-mediated signaling pathway Another extracted example is TNFRSF9 → appendix, blastocyst, blood, buccal mucosa cell, cartilage tissue, decidua, gallbladder, gastrula, granulocyte, islet of Langerhans, lymph node, mesenteric lymph nodes, monocyte, morula, testicle, thymus, uterus, white blood cell. Use these groups to spot repeated connection types before inspecting the individual relationships.
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cd137 cells cell immune human bp cancer ligand gene expressed chr band receptor atherosclerosis target proliferation secretion chromosome system immunotherapy
TTTA extracted 79 structured relationships around TNFRSF9. Examples in this analysis include TNFRSF9 → Aliases → TNFRSF9, 4-1BB, CD137, CDw137, ILA, tumor necrosis factor receptor superfamily member 9, TNF receptor superfamily member 9 and TNFRSF9 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1D0J. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| TNFRSF9 | Aliases | TNFRSF9, 4-1BB, CD137, CDw137, ILA, tumor necrosis factor receptor superfamily member 9, TNF receptor superfamily member 9 | 1.00 | infobox |
| TNFRSF9 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1D0J | 1.00 | infobox |
| TNFRSF9 | Band | 1p36.23 | 1.00 | infobox |
| TNFRSF9 | Band | 4 E2|4 81.52 cM | 1.00 | infobox |
| TNFRSF9 | Bgee | buccal mucosa cell | 1.00 | infobox |
| TNFRSF9 | Bgee | lymph node | 1.00 | infobox |
| TNFRSF9 | Bgee | cartilage tissue | 1.00 | infobox |
| TNFRSF9 | Bgee | testicle | 1.00 | infobox |
| TNFRSF9 | Bgee | blood | 1.00 | infobox |
| TNFRSF9 | Bgee | appendix | 1.00 | infobox |
| TNFRSF9 | Bgee | white blood cell | 1.00 | infobox |
| TNFRSF9 | Bgee | monocyte | 1.00 | infobox |
| TNFRSF9 | Bgee | granulocyte | 1.00 | infobox |
| TNFRSF9 | Bgee | gallbladder | 1.00 | infobox |
| TNFRSF9 | Bgee | decidua | 1.00 | infobox |
| TNFRSF9 | Bgee | gastrula | 1.00 | infobox |
| TNFRSF9 | Bgee | blastocyst | 1.00 | infobox |
| TNFRSF9 | Bgee | thymus | 1.00 | infobox |
| TNFRSF9 | Bgee | mesenteric lymph nodes | 1.00 | infobox |
| TNFRSF9 | Bgee | islet of Langerhans | 1.00 | infobox |
| TNFRSF9 | Bgee | uterus | 1.00 | infobox |
| TNFRSF9 | Bgee | morula | 1.00 | infobox |
| TNFRSF9 | BioGPS | More reference expression data | 1.00 | infobox |
| TNFRSF9 | Chr. | Chromosome 1 (human) | 1.00 | infobox |
| TNFRSF9 | Chr. | Chromosome 4 (mouse) | 1.00 | infobox |
| TNFRSF9 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| TNFRSF9 | End | 7,943,165 bp | 1.00 | infobox |
| TNFRSF9 | End | 151,030,559 bp | 1.00 | infobox |
| TNFRSF9 | Ensembl | ENSG00000049249 | 1.00 | infobox |
| TNFRSF9 | Entrez | 3604 | 1.00 | infobox |
The concept neighborhoods around TNFRSF9 bring nearby vocabulary together. In this analysis, examples include Mouse, Tnf and Cytokine. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For TNFRSF9, one of the stronger structural bridges in this analysis connects TNFRSF9 with Expression. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around TNFRSF9 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Expression, Atherosclerosis & Regulation of the immune system, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — TNFRSF9 · EN edition · Analysis: TopicsToTalkAbout