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TNFRSF9: Expression, Atherosclerosis & Regulation of the immune system

TNF receptor superfamily member 9, a member of the TNF receptor superfamily, is a type 1 transmembrane protein, expressed on surfaces of leukocytes and non-immune cells. Its alternative names are CD137, 4-1BB, and induced by lymphocyte activation (ILA). It is of interest to immunologists as a co-stimulatory immune checkpoint molecule, and as a potential…

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TNFRSF9 topic overview

The analysis highlights Expression, Atherosclerosis and Regulation of the immune system as prominent areas in the source structure around TNFRSF9.

Related topics
34
Source areas
6
Connected nodes
40
Extracted relationships
79
Related term clusters
19
Bridge connections
40

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Expression · 18 topics
Atherosclerosis · 6 topics
Overview · 5 topics
Interactions · 2 topics
Regulation of the immune system · 2 topics
As a drug target · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
TNFRSF9, 4-1BB, CD137, CDw137, ILA, tumor necrosis factor receptor superfamily member 9, TNF receptor superfamily member 9
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1D0J
Band
1p36.23 · 4 E2|4 81.52 cM
Bgee
buccal mucosa cell · lymph node · cartilage tissue · testicle · blood
BioGPS
More reference expression data
Chr.
Chromosome 1 (human) · Chromosome 4 (mouse)

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TNFRSF9
5TNF receptor superfamily · Type 1 transmembrane protein · Immune checkpoint
5Dendritic cell · B cell · Antibody
9Monocyte · Natural killer cell · Follicular dendritic cells

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Expression

Regulation of the immune system

Atherosclerosis

Interactions

As a drug target

For the semantics nerds

You can skip this section if you’re here for content ideas and keyword inspiration.

Advanced semantic analysis

How TNFRSF9 connects Entity context

The extracted context around TNFRSF9 shows recurring relationship patterns in the source. For example, TNFRSF9 → apoptotic process, apoptotic signaling pathway, cytokine binding, external side of plasma membrane, extracellular space, immune response, inflammatory response, integral component of membrane, integral component of plasma membrane, membrane, multicellular organism development, negative regulation of cell population proliferation, plasma membrane, protein homotrimerization, regulation of apoptotic process, regulation of cell population proliferation, response to lipopolysaccharide, signaling receptor activity, tumor necrosis factor-activated receptor activity, tumor necrosis factor-mediated signaling pathway Another extracted example is TNFRSF9 → appendix, blastocyst, blood, buccal mucosa cell, cartilage tissue, decidua, gallbladder, gastrula, granulocyte, islet of Langerhans, lymph node, mesenteric lymph nodes, monocyte, morula, testicle, thymus, uterus, white blood cell. Use these groups to spot repeated connection types before inspecting the individual relationships.

TNFRSF9

Top relations

Gene ontology · 20
TNFRSF9 → apoptotic process, apoptotic signaling pathway, cytokine binding, external side of plasma membrane, extracellular space, immune response, inflammatory response, integral component of membrane, integral component of plasma membrane, membrane, multicellular organism development, negative regulation of cell population proliferation, plasma membrane, protein homotrimerization, regulation of apoptotic process, regulation of cell population proliferation, response to lipopolysaccharide, signaling receptor activity, tumor necrosis factor-activated receptor activity, tumor necrosis factor-mediated signaling pathway
Bgee · 18
TNFRSF9 → appendix, blastocyst, blood, buccal mucosa cell, cartilage tissue, decidua, gallbladder, gastrula, granulocyte, islet of Langerhans, lymph node, mesenteric lymph nodes, monocyte, morula, testicle, thymus, uterus, white blood cell
RNA expression pattern · 18
TNFRSF9 → appendix, blastocyst, blood, buccal mucosa cell, cartilage tissue, decidua, gallbladder, gastrula, granulocyte, islet of Langerhans, lymph node, mesenteric lymph nodes, monocyte, morula, testicle, thymus, uterus, white blood cell
Band · 2
TNFRSF9 → 1p36.23, 4 E2|4 81.52 cM
Chr. · 2
TNFRSF9 → Chromosome 1 (human), Chromosome 4 (mouse)
End · 2
TNFRSF9 → 151,030,559 bp, 7,943,165 bp
Aliases · 1
TNFRSF9 → TNFRSF9, 4-1BB, CD137, CDw137, ILA, tumor necrosis factor receptor superfamily member 9, TNF receptor superfamily member 9
Available structures · 1
TNFRSF9 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1D0J
BioGPS · 1
TNFRSF9 → More reference expression data
Databases · 1
TNFRSF9 → NCBI: entry; OMA: entry

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

cd137 cells cell immune human bp cancer ligand gene expressed chr band receptor atherosclerosis target proliferation secretion chromosome system immunotherapy

TNFRSF9 relationships Subject–Predicate–Object triples

TTTA extracted 79 structured relationships around TNFRSF9. Examples in this analysis include TNFRSF9 → Aliases → TNFRSF9, 4-1BB, CD137, CDw137, ILA, tumor necrosis factor receptor superfamily member 9, TNF receptor superfamily member 9 and TNFRSF9 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1D0J. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
TNFRSF9AliasesTNFRSF9, 4-1BB, CD137, CDw137, ILA, tumor necrosis factor receptor superfamily member 9, TNF receptor superfamily member 91.00infobox
TNFRSF9Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1D0J1.00infobox
TNFRSF9Band1p36.231.00infobox
TNFRSF9Band4 E2|4 81.52 cM1.00infobox
TNFRSF9Bgeebuccal mucosa cell1.00infobox
TNFRSF9Bgeelymph node1.00infobox
TNFRSF9Bgeecartilage tissue1.00infobox
TNFRSF9Bgeetesticle1.00infobox
TNFRSF9Bgeeblood1.00infobox
TNFRSF9Bgeeappendix1.00infobox
TNFRSF9Bgeewhite blood cell1.00infobox
TNFRSF9Bgeemonocyte1.00infobox
TNFRSF9Bgeegranulocyte1.00infobox
TNFRSF9Bgeegallbladder1.00infobox
TNFRSF9Bgeedecidua1.00infobox
TNFRSF9Bgeegastrula1.00infobox
TNFRSF9Bgeeblastocyst1.00infobox
TNFRSF9Bgeethymus1.00infobox
TNFRSF9Bgeemesenteric lymph nodes1.00infobox
TNFRSF9Bgeeislet of Langerhans1.00infobox
TNFRSF9Bgeeuterus1.00infobox
TNFRSF9Bgeemorula1.00infobox
TNFRSF9BioGPSMore reference expression data1.00infobox
TNFRSF9Chr.Chromosome 1 (human)1.00infobox
TNFRSF9Chr.Chromosome 4 (mouse)1.00infobox
TNFRSF9DatabasesNCBI: entry; OMA: entry1.00infobox
TNFRSF9End7,943,165 bp1.00infobox
TNFRSF9End151,030,559 bp1.00infobox
TNFRSF9EnsemblENSG000000492491.00infobox
TNFRSF9Entrez36041.00infobox

Related concept clusters Related term clusters

The concept neighborhoods around TNFRSF9 bring nearby vocabulary together. In this analysis, examples include Mouse, Tnf and Cytokine. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • tnf receptor superfamily
    • Expression
    • External
    • Tnf
    • Chromosome
    • Location
    • Regulation
    • Tnfrsf9
    • Utomilumab
    • Bp
    • Chr
    • Expressed
    • Gene
  • immune checkpoint
    • System
    • Cd137
    • Target
    • Proliferation
    • Cell
    • Also
    • Expression
    • Regulation
    • Receptor
    • Secretion
    • Cancer
    • External
  • cancer immunotherapy
    • Target
    • Immunotherapy
    • Cells
    • Molecule
    • Cell
    • Also
    • External
    • System
    • Tnf
    • Cd137
    • Immune
    • Endothelial
  • gene
    • Location
    • Tnfrsf9
    • Human
    • Chromosome
    • Bp
    • Chr
    • External
    • Mouse
    • Band
    • Expression
    • Regulation
    • Receptor
  • t cells
    • Cancer
    • Cd137
    • Immune
    • Target
    • Endothelial
    • Surfaces
    • Cell
    • System
    • Secretion
    • Tnf
    • Also
    • Immunotherapy
  • antigen presenting cells (apcs)
    • Cancer
    • Cd137
    • Immune
    • Target
    • Endothelial
    • Surfaces
    • Cell
    • System
    • Secretion
    • Tnf
    • Also
    • Immunotherapy
  • dendritic cell
    • Proliferation
    • Signaling
    • Secretion
    • Cells
    • Immune
    • Inflammatory
    • Responses
    • Cytokine
    • Molecule
    • Surfaces
    • Expression
    • Expressed
  • b cell
    • Proliferation
    • Signaling
    • Secretion
    • Cells
    • Immune
    • Inflammatory
    • Responses
    • Cytokine
    • Molecule
    • Surfaces
    • Expression
    • Expressed

Connections between topic areas Semantic bridges

For TNFRSF9, one of the stronger structural bridges in this analysis connects TNFRSF9 with Expression. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
TNFRSF9 — Expression · splits 22 ⟂ 19
TNFRSF9 — Atherosclerosis · splits 34 ⟂ 7
TNFRSF9 — Overview · splits 35 ⟂ 6
TNFRSF9 — Regulation of the immune system · splits 38 ⟂ 3
TNFRSF9 — Interactions · splits 38 ⟂ 3

Map overview Semantic statistics

TNFRSF9

Nodes41
Edges40
Triples79
Avg. degree1.95
Density0.04878
Components1

Source & methodology

TTTA analyzes the structure around TNFRSF9 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Expression, Atherosclerosis & Regulation of the immune system, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — TNFRSF9 · EN edition · Analysis: TopicsToTalkAbout

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