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TNFRSF9

TNF receptor superfamily member 9, a member of the TNF receptor superfamily, is a type 1 transmembrane protein, expressed on surfaces of leukocytes and non-immune cells. Its alternative names are CD137, 4-1BB, and induced by lymphocyte activation (ILA). It is of interest to immunologists as a co-stimulatory immune checkpoint molecule, and as a potential…

Expression, Atherosclerosis & Regulation of the immune system

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Aliases
TNFRSF9, 4-1BB, CD137, CDw137, ILA, tumor necrosis factor receptor superfamily member 9, TNF receptor superfamily member 9
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1D0J
Band
1p36.23 · 4 E2|4 81.52 cM
Bgee
buccal mucosa cell · lymph node · cartilage tissue · testicle · blood
BioGPS
More reference expression data
Chr.
Chromosome 1 (human) · Chromosome 4 (mouse)

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Overview

Expression

Regulation of the immune system

Atherosclerosis

Interactions

As a drug target

Advanced semantic analysis

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Map overview Semantic statistics

TNFRSF9

Nodes41
Edges40
Triples81
Avg. degree1.95
Density0.04878
Components1

How this topic connects Entity context

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TNFRSF9

Top relations

Gene ontology · 20
TNFRSF9 → apoptotic process, apoptotic signaling pathway, cytokine binding, external side of plasma membrane, extracellular space, immune response, inflammatory response, integral component of membrane, integral component of plasma membrane, membrane, multicellular organism development, negative regulation of cell population proliferation, plasma membrane, protein homotrimerization, regulation of apoptotic process, regulation of cell population proliferation, response to lipopolysaccharide, signaling receptor activity, tumor necrosis factor-activated receptor activity, tumor necrosis factor-mediated signaling pathway
Bgee · 18
TNFRSF9 → appendix, blastocyst, blood, buccal mucosa cell, cartilage tissue, decidua, gallbladder, gastrula, granulocyte, islet of Langerhans, lymph node, mesenteric lymph nodes, monocyte, morula, testicle, thymus, uterus, white blood cell
RNA expression pattern · 18
TNFRSF9 → appendix, blastocyst, blood, buccal mucosa cell, cartilage tissue, decidua, gallbladder, gastrula, granulocyte, islet of Langerhans, lymph node, mesenteric lymph nodes, monocyte, morula, testicle, thymus, uterus, white blood cell
Band · 2
TNFRSF9 → 1p36.23, 4 E2|4 81.52 cM
Chr. · 2
TNFRSF9 → Chromosome 1 (human), Chromosome 4 (mouse)
End · 2
TNFRSF9 → 151,030,559 bp, 7,943,165 bp
related to External links · 2
TNFRSF9 → Human TNFRSF9, UCSC Genome Browser
Aliases · 1
TNFRSF9 → TNFRSF9, 4-1BB, CD137, CDw137, ILA, tumor necrosis factor receptor superfamily member 9, TNF receptor superfamily member 9
Available structures · 1
TNFRSF9 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1D0J
BioGPS · 1
TNFRSF9 → More reference expression data

Important terminology Word statistics

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Important terminology

cd137 cells cell immune human bp cancer ligand gene expressed chr band receptor atherosclerosis target proliferation secretion chromosome system immunotherapy

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
TNFRSF9AliasesTNFRSF9, 4-1BB, CD137, CDw137, ILA, tumor necrosis factor receptor superfamily member 9, TNF receptor superfamily member 91.00infobox
TNFRSF9Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1D0J1.00infobox
TNFRSF9Band1p36.231.00infobox
TNFRSF9Band4 E2|4 81.52 cM1.00infobox
TNFRSF9Bgeebuccal mucosa cell1.00infobox
TNFRSF9Bgeelymph node1.00infobox
TNFRSF9Bgeecartilage tissue1.00infobox
TNFRSF9Bgeetesticle1.00infobox
TNFRSF9Bgeeblood1.00infobox
TNFRSF9Bgeeappendix1.00infobox
TNFRSF9Bgeewhite blood cell1.00infobox
TNFRSF9Bgeemonocyte1.00infobox
TNFRSF9Bgeegranulocyte1.00infobox
TNFRSF9Bgeegallbladder1.00infobox
TNFRSF9Bgeedecidua1.00infobox
TNFRSF9Bgeegastrula1.00infobox
TNFRSF9Bgeeblastocyst1.00infobox
TNFRSF9Bgeethymus1.00infobox
TNFRSF9Bgeemesenteric lymph nodes1.00infobox
TNFRSF9Bgeeislet of Langerhans1.00infobox
TNFRSF9Bgeeuterus1.00infobox
TNFRSF9Bgeemorula1.00infobox
TNFRSF9BioGPSMore reference expression data1.00infobox
TNFRSF9Chr.Chromosome 1 (human)1.00infobox
TNFRSF9Chr.Chromosome 4 (mouse)1.00infobox
TNFRSF9DatabasesNCBI: entry; OMA: entry1.00infobox
TNFRSF9End7,943,165 bp1.00infobox
TNFRSF9End151,030,559 bp1.00infobox
TNFRSF9EnsemblENSG000000492491.00infobox
TNFRSF9Entrez36041.00infobox

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