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Thienamycin

Thienamycin (also known as thienpenem) is one of the most potent naturally produced antibiotics known thus far, discovered in Streptomyces cattleya in 1976. Thienamycin has excellent activity against both Gram-positive and Gram-negative bacteria and is resistant to bacterial β-lactamase enzymes. Thienamycin is a zwitterion at pH 7.

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Overview

History

Mechanism of action

Biosynthesis

Clinical use

Advanced semantic analysis

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Map overview Semantic statistics

Thienamycin

Nodes39
Edges38
Triples40
Avg. degree1.95
Density0.051282
Components1

How this topic connects Entity context

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Thienamycin

Top relations

related to Mechanism of action · 11
Thienamycin → Although, Escherichia, Gram-negative, Gram-positive, In, PBP-1, PBP-2, PBPs, Pseudomonas, Staphylococcus, Unlike
related to Biosynthesis · 9
Thienamycin → ACV, ACVS, At, ATP, CoA, First, IPNS, Production, The
related to history · 9
Thienamycin → After, C1, C2, C3, Carbapenems, In, Initial, Like, Streptomyces
related to Clinical use · 5
Thienamycin → Imipenem, N-formimidoyl, One, Since, To
related to Total synthesis · 5
Thienamycin → Due, Figure, Numerous, One, The
is a · 1
Thienamycin → zwitterion at pH 7

Important terminology Word statistics

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Important terminology

biosynthesis penicillins bacteria carbapenems β-lactam ring synthesis citation needed thought one cattleya β-lactams imipenem total use given β-lactamase references active

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Thienamycinis azwitterion at pH 70.90text
Thienamycinrelated to BiosynthesisThe0.60section
Thienamycinrelated to BiosynthesisProduction0.60section
Thienamycinrelated to BiosynthesisFirst0.60section
Thienamycinrelated to BiosynthesisACV0.60section
Thienamycinrelated to BiosynthesisACVS0.60section
Thienamycinrelated to BiosynthesisIPNS0.60section
Thienamycinrelated to BiosynthesisCoA0.60section
Thienamycinrelated to BiosynthesisATP0.60section
Thienamycinrelated to BiosynthesisAt0.60section
Thienamycinrelated to Clinical useSince0.60section
Thienamycinrelated to Clinical useOne0.60section

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