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Imipenem: Applications, Medical uses & Overview

Imipenem, sold under the brand name Primaxin among others, is a synthetic β-lactam antibiotic belonging to the carbapenems chemical class, developed by Merck scientists Burton Christensen, William Leanza, and Kenneth Wildonger in the mid-1970s. Carbapenems are highly resistant to the β-lactamase enzymes produced by many multiple drug-resistant…

Language: English [EN]
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Imipenem topic overview

The analysis highlights Applications, Medical uses and Overview as prominent areas in the source structure around Imipenem.

Related topics
26
Source areas
3
Connected nodes
29
Extracted relationships
43
Concept neighborhoods
17
Bridge connections
29

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 13 topics
Medical uses · 11 topics
Adverse effects · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
AHFS/Drugs.com
International Drug Names
ATC code
J01DH51 (WHO)
CAS Number
64221-86-9 Y
ChEBI
CHEBI:51799 Y
ChEMBL
ChEMBL43708 Y

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Medical uses

Adverse effects

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Imipenem connects Entity context

The extracted context around Imipenem shows recurring relationship patterns in the source. For example, Imipenem → Acinetobacter, Actinomyces, Aeromonas, Bacteroides, Clostridium, Enterococcus, Not, Oman, Pseudomonas, Stenotrophomonas Another extracted example is Imipenem → AU: S4 (Prescription only), CA: ℞-only, UK: POM (Prescription only), US: ℞-only. Use these groups to spot repeated connection types before inspecting the individual relationships.

Imipenem

Top relations

related to Spectrum of bacterial susceptibility and resistance · 10
Imipenem → Acinetobacter, Actinomyces, Aeromonas, Bacteroides, Clostridium, Enterococcus, Not, Oman, Pseudomonas, Stenotrophomonas
Legal status · 4
Imipenem → AU: S4 (Prescription only), CA: ℞-only, UK: POM (Prescription only), US: ℞-only
has effect · 3
Imipenem → At, Common, People
3D model (JSmol) · 1
Imipenem → Interactive image
AHFS/Drugs.com · 1
Imipenem → International Drug Names
ATC code · 1
Imipenem → J01DH51 (WHO)
CAS Number · 1
Imipenem → 64221-86-9 Y
ChEBI · 1
Imipenem → CHEBI:51799 Y
ChEMBL · 1
Imipenem → ChEMBL43708 Y
ChemSpider · 1
Imipenem → 4445535 Y

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

developed carbapenems gram-negative bacteria thienamycin intravenous produced thus use activity medical spectrum name primaxin others key β-lactam resistant many antibiotics

Imipenem relationships Subject–Predicate–Object triples

TTTA extracted 43 structured relationships around Imipenem. Examples in this analysis include Imipenem → 3D model (JSmol) → Interactive image and Imipenem → AHFS/Drugs.com → International Drug Names. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Imipenem3D model (JSmol)Interactive image1.00infobox
ImipenemAHFS/Drugs.comInternational Drug Names1.00infobox
ImipenemATC codeJ01DH51 (WHO)1.00infobox
ImipenemCAS Number64221-86-9 Y1.00infobox
ImipenemChEBICHEBI:51799 Y1.00infobox
ImipenemChEMBLChEMBL43708 Y1.00infobox
ImipenemChemSpider4445535 Y1.00infobox
ImipenemCompTox Dashboard (EPA)DTXSID20231431.00infobox
ImipenemDrugBankDB01598 Y1.00infobox
ImipenemECHA InfoCard100.058.8311.00infobox
ImipenemElimination half-life38 minutes (children), 60 minutes (adults)1.00infobox
ImipenemExcretionUrine (70%)1.00infobox
ImipenemFormulaC12H17N3O4S1.00infobox
ImipenemKEGGD04515 Y1.00infobox
ImipenemLegal statusAU: S4 (Prescription only)1.00infobox
ImipenemLegal statusCA: ℞-only1.00infobox
ImipenemLegal statusUK: POM (Prescription only)1.00infobox
ImipenemLegal statusUS: ℞-only1.00infobox
ImipenemLicense dataUS DailyMed: Imipenem1.00infobox
ImipenemMedlinePlusa6860131.00infobox
ImipenemMetabolismKidney1.00infobox
ImipenemMolar mass299.35 g·mol−11.00infobox
ImipenemPDB ligandIM2 (PDBe, RCSB PDB)1.00infobox
ImipenemPregnancy categoryAU: B31.00infobox
ImipenemProtein binding20%1.00infobox
ImipenemPubChem CID1048381.00infobox
ImipenemRoutes of administrationIntramuscular, intravenous1.00infobox
ImipenemTrade namesPrimaxin, others1.00infobox
ImipenemUNIIQ20IM7HE751.00infobox
Imipenemis atherapeutic alternative on the World Health Organization's List of Essential Medicines0.90text

Related concept clusters Concept neighborhoods

The concept neighborhoods around Imipenem bring nearby vocabulary together. In this analysis, examples include Cilastatin, High and Medical. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Imipenem
    • Cilastatin
    • High
    • Medical
    • Name
    • Others
    • Primaxin
    • Spectrum
    • Β-lactam
    • Developed
    • Aerobic
    • Among
    • Anaerobic
  • imipenem
    • Cilastatin
    • High
    • Medical
    • Name
    • Others
    • Primaxin
    • Spectrum
    • Β-lactam
    • Developed
    • Aerobic
    • Among
    • Anaerobic
  • carbapenems
    • Chemical
    • Class
    • Merck
    • Sold
    • Synthetic
    • Β-lactamase
    • Antibiotics
    • Bacteria
    • Gram-negative
    • Key
    • Many
    • Name
  • β-lactam
    • Among
    • Antibiotic
    • Belonging
    • Brand
    • Chemical
    • Class
    • Merck
    • Sold
    • Synthetic
    • Antibiotics
    • Carbapenems
    • High
  • bacteria
    • Gram-negative
    • Aerobic
    • Anaerobic
    • Gram-positive
    • Β-lactamase
    • Activity
    • Antibiotics
    • Carbapenems
    • Key
    • Many
    • Produced
    • Resistant
  • antibiotic
    • Belonging
    • Brand
    • Chemical
    • Class
    • Merck
    • Sold
    • Synthetic
    • Carbapenems
    • Name
    • Others
    • Primaxin
    • Β-lactam
  • gram-negative
    • Aerobic
    • Anaerobic
    • Gram-positive
    • Β-lactamase
    • Activity
    • Key
    • Many
    • Produced
    • Resistant
    • Spectrum
    • Thus
    • Imipenem
  • cilastatin
    • Resistance
    • Adverse
    • Drug
    • Intravenous
    • Key
    • Medical
    • Name
    • Others
    • Primaxin
    • Spectrum
    • Developed
    • Imipenem

Connections between topic areas Semantic bridges

For Imipenem, one of the stronger structural bridges in this analysis connects Imipenem with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Imipenem — Overview · splits 16 ⟂ 14
Imipenem — Medical uses · splits 18 ⟂ 12
Imipenem — Adverse effects · splits 27 ⟂ 3

Map overview Semantic statistics

Imipenem

Nodes30
Edges29
Triples43
Avg. degree1.93
Density0.066667
Components1

Source & methodology

TTTA analyzes the structure around Imipenem to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Applications, Medical uses & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Imipenem · EN edition · Analysis: TopicsToTalkAbout

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