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Natural resistance-associated macrophage protein 2

Natural resistance-associated macrophage protein 2 (NRAMP 2), also known as divalent metal transporter 1 (DMT1) and divalent cation transporter 1 (DCT1), is a protein that in humans is encoded by the SLC11A2 (solute carrier family 11, member 2) gene. DMT1 represents a large family of orthologous metal ion transporter proteins that are highly conserved…

Role in neurodegenerative diseases, Function & Overview

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Aliases
SLC11A2, DCT1, DMT1, NRAMP2, AHMIO1, solute carrier family 11 member 2, divalent metal transporter 1, natural resistance-associated macrophage protein 2, divalent cation transpo…
Band
12q13.12 · 15 F1|15 56.29 cM
Bgee
inferior ganglion of vagus nerve · buccal mucosa cell · caput epididymis · corpus callosum · cartilage tissue
BioGPS
More reference expression data
Chr.
Chromosome 12 (human) · Chromosome 15 (mouse)
Databases
NCBI: entry; OMA: entry

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Role in neurodegenerative diseases

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Natural resistance-associated macrophage protein 2

Nodes32
Edges31
Triples151
Avg. degree1.94
Density0.0625
Components1

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Natural resistance-associated macrophage protein 2

Top relations

Gene ontology · 89
Natural resistance-associated macrophage protein 2 → activation of cysteine-type endopeptidase activity involved in apoptotic process, apical part of cell, apical plasma membrane, basal part of cell, brush border, brush border membrane, cadmium ion binding, cadmium ion transmembrane transport, cadmium ion transmembrane transporter activity, calcium ion transmembrane transporter activity, cation transmembrane transport, cell surface, cellular iron ion homeostasis, cellular response to oxidative stress, chromium ion transmembrane transporter activity, cobalt ion binding, cobalt ion transmembrane transporter activity, cobalt ion transport, copper ion binding, copper ion transmembrane transport
Bgee · 20
Natural resistance-associated macrophage protein 2 → buccal mucosa cell, caput epididymis, cartilage tissue, corpus callosum, duodenum, epithelium of small intestine, fetal liver hematopoietic progenitor cell, Ileal epithelium, inferior ganglion of vagus nerve, lip, minor salivary glands, oral cavity, pons, primary oocyte, proximal tubule, right kidney, spermatocyte, subthalamic nucleus, superior vestibular nucleus, yolk sac
RNA expression pattern · 20
Natural resistance-associated macrophage protein 2 → buccal mucosa cell, caput epididymis, cartilage tissue, corpus callosum, duodenum, epithelium of small intestine, fetal liver hematopoietic progenitor cell, Ileal epithelium, inferior ganglion of vagus nerve, lip, minor salivary glands, oral cavity, pons, primary oocyte, proximal tubule, right kidney, spermatocyte, subthalamic nucleus, superior vestibular nucleus, yolk sac
Band · 2
Natural resistance-associated macrophage protein 2 → 12q13.12, 15 F1|15 56.29 cM
Chr. · 2
Natural resistance-associated macrophage protein 2 → Chromosome 12 (human), Chromosome 15 (mouse)
End · 2
Natural resistance-associated macrophage protein 2 → 100,322,953 bp, 51,028,566 bp
Aliases · 1
Natural resistance-associated macrophage protein 2 → SLC11A2, DCT1, DMT1, NRAMP2, AHMIO1, solute carrier family 11 member 2, divalent metal transporter 1, natural resistance-associated macrophage protein 2, divalent cation transpo…
BioGPS · 1
Natural resistance-associated macrophage protein 2 → More reference expression data
Databases · 1
Natural resistance-associated macrophage protein 2 → NCBI: entry; OMA: entry
Ensembl · 1
Natural resistance-associated macrophage protein 2 → ENSG00000110911

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Important terminology

dmt1 iron transporter metal cell divalent protein human bp gene slc11a2 chr band also chromosome 12 manganese membrane transport ferrous

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Natural resistance-associated macrophage protein 2AliasesSLC11A2, DCT1, DMT1, NRAMP2, AHMIO1, solute carrier family 11 member 2, divalent metal transporter 1, natural resistance-associated macrophage protein 2, divalent cation transpo…1.00infobox
Natural resistance-associated macrophage protein 2Band12q13.121.00infobox
Natural resistance-associated macrophage protein 2Band15 F1|15 56.29 cM1.00infobox
Natural resistance-associated macrophage protein 2Bgeeinferior ganglion of vagus nerve1.00infobox
Natural resistance-associated macrophage protein 2Bgeebuccal mucosa cell1.00infobox
Natural resistance-associated macrophage protein 2Bgeecaput epididymis1.00infobox
Natural resistance-associated macrophage protein 2Bgeecorpus callosum1.00infobox
Natural resistance-associated macrophage protein 2Bgeecartilage tissue1.00infobox
Natural resistance-associated macrophage protein 2Bgeeoral cavity1.00infobox
Natural resistance-associated macrophage protein 2Bgeeminor salivary glands1.00infobox
Natural resistance-associated macrophage protein 2Bgeesuperior vestibular nucleus1.00infobox
Natural resistance-associated macrophage protein 2Bgeesubthalamic nucleus1.00infobox
Natural resistance-associated macrophage protein 2Bgeepons1.00infobox
Natural resistance-associated macrophage protein 2Bgeeepithelium of small intestine1.00infobox
Natural resistance-associated macrophage protein 2BgeeIleal epithelium1.00infobox
Natural resistance-associated macrophage protein 2Bgeespermatocyte1.00infobox
Natural resistance-associated macrophage protein 2Bgeeduodenum1.00infobox
Natural resistance-associated macrophage protein 2Bgeelip1.00infobox
Natural resistance-associated macrophage protein 2Bgeeright kidney1.00infobox
Natural resistance-associated macrophage protein 2Bgeeprimary oocyte1.00infobox
Natural resistance-associated macrophage protein 2Bgeefetal liver hematopoietic progenitor cell1.00infobox
Natural resistance-associated macrophage protein 2Bgeeproximal tubule1.00infobox
Natural resistance-associated macrophage protein 2Bgeeyolk sac1.00infobox
Natural resistance-associated macrophage protein 2BioGPSMore reference expression data1.00infobox
Natural resistance-associated macrophage protein 2Chr.Chromosome 12 (human)1.00infobox
Natural resistance-associated macrophage protein 2Chr.Chromosome 15 (mouse)1.00infobox
Natural resistance-associated macrophage protein 2DatabasesNCBI: entry; OMA: entry1.00infobox
Natural resistance-associated macrophage protein 2End51,028,566 bp1.00infobox
Natural resistance-associated macrophage protein 2End100,322,953 bp1.00infobox
Natural resistance-associated macrophage protein 2EnsemblENSG000001109111.00infobox

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