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Ferroportin

Ferroportin-1, also known as solute carrier family 40 member 1 (SLC40A1) or iron-regulated transporter 1 (IREG1), is a protein that in humans is encoded by the SLC40A1 gene. Ferroportin is a transmembrane protein that transports iron from the inside of a cell to the outside of the cell. Ferroportin is the only known iron exporter.

Structure, Function & Role in development

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Aliases
SLC40A1, IREG1, MST079, MSTP079, solute carrier family 40 member 1, MTP1, SLC11A3, FPN1, HFE4
Band
2q32.2 · 1|1 C1.1
Bgee
pancreatic ductal cell · jejunal mucosa · mucosa of ileum · germinal epithelium · trabecular bone
BioGPS
n/a
Chr.
Chromosome 2 (human) · Chromosome 1 (mouse)
Databases
NCBI: entry; OMA: entry

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Overview

Structure

Function

Tissue distribution

Role in development

Role in fertility

Role in iron metabolism

Clinical significance

Protein family

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Map overview Semantic statistics

Ferroportin

Nodes55
Edges54
Triples146
Avg. degree1.96
Density0.036364
Components1

How this topic connects Entity context

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Ferroportin

Top relations

Gene ontology · 29
Ferroportin → basolateral plasma membrane, cellular iron ion homeostasis, cytoplasm, cytosol, endothelium development, ferrous iron transmembrane transporter activity, identical protein binding, integral component of membrane, integral component of plasma membrane, intracellular anatomical structure, ion transport, iron ion export across plasma membrane, iron ion homeostasis, iron ion transmembrane transport, iron ion transmembrane transporter activity, iron ion transport, lymphocyte homeostasis, membrane, multicellular organismal iron ion homeostasis, negative regulation of apoptotic process
Bgee · 19
Ferroportin → cardiac muscle tissue of right atrium, decidua, duodenum, epithelium of small intestine, germinal epithelium, granulocyte, ileum, jejunal mucosa, left colon, liver, medullary collecting duct, mucosa of ileum, palpebral conjunctiva, pancreatic ductal cell, spleen, stroma of bone marrow, superficial temporal artery, tibiofemoral joint, trabecular bone
RNA expression pattern · 19
Ferroportin → cardiac muscle tissue of right atrium, decidua, duodenum, epithelium of small intestine, germinal epithelium, granulocyte, ileum, jejunal mucosa, left colon, liver, medullary collecting duct, mucosa of ileum, palpebral conjunctiva, pancreatic ductal cell, spleen, stroma of bone marrow, superficial temporal artery, tibiofemoral joint, trabecular bone
related to External links · 11
Ferroportin → All, As, Creative Commons Attribution-ShareAlike, Family, Fpn, GFDL, Medicine Medical Subject Headings, MeSH, National Library, The Ferroportin, Unported License
related to Structure · 11
Ferroportin → Bdellovibrio, C-terminal, Fpn, H32, Human Fpn, Members, MFS, N-terminal, Recent, The, When H32
related to Role in development · 8
Ferroportin → E7, Ferroportin-1, Fpn1, Further, Furthermore, Given, Mouse, Slc40a1
related to Role in iron metabolism · 7
Ferroportin → Ganz, Hepcidin, If, IRP, RNA, The, This
related to Function · 6
Ferroportin → Ferroportin-mediated, Fpn, In, The, Thus, Xenopus
related to Clinical significance · 5
Ferroportin → African, Ferroportin Disease, Hemochromatosis, Mutations, The
related to Role in fertility · 4
Ferroportin → It, Its, SLC40A1, What's

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Important terminology

iron fpn gene protein human also family bp slc40a1 hepcidin chr band known chromosome cell mouse transport activity liver function

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
FerroportinAliasesSLC40A1, IREG1, MST079, MSTP079, solute carrier family 40 member 1, MTP1, SLC11A3, FPN1, HFE41.00infobox
FerroportinBand2q32.21.00infobox
FerroportinBand1|1 C1.11.00infobox
FerroportinBgeepancreatic ductal cell1.00infobox
FerroportinBgeejejunal mucosa1.00infobox
FerroportinBgeemucosa of ileum1.00infobox
FerroportinBgeegerminal epithelium1.00infobox
FerroportinBgeetrabecular bone1.00infobox
FerroportinBgeedecidua1.00infobox
FerroportinBgeecardiac muscle tissue of right atrium1.00infobox
FerroportinBgeepalpebral conjunctiva1.00infobox
FerroportinBgeesuperficial temporal artery1.00infobox
FerroportinBgeeduodenum1.00infobox
FerroportinBgeeepithelium of small intestine1.00infobox
FerroportinBgeemedullary collecting duct1.00infobox
FerroportinBgeestroma of bone marrow1.00infobox
FerroportinBgeespleen1.00infobox
FerroportinBgeetibiofemoral joint1.00infobox
FerroportinBgeeleft colon1.00infobox
FerroportinBgeegranulocyte1.00infobox
FerroportinBgeeliver1.00infobox
FerroportinBgeeileum1.00infobox
FerroportinBioGPSn/a1.00infobox
FerroportinChr.Chromosome 2 (human)1.00infobox
FerroportinChr.Chromosome 1 (mouse)1.00infobox
FerroportinDatabasesNCBI: entry; OMA: entry1.00infobox
FerroportinEnd189,583,758 bp1.00infobox
FerroportinEnd45,965,683 bp1.00infobox
FerroportinEnsemblENSG000001384491.00infobox
FerroportinEntrez300611.00infobox

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