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Ferroportin: Structure, Function & Role in development

Ferroportin-1, also known as solute carrier family 40 member 1 (SLC40A1) or iron-regulated transporter 1 (IREG1), is a protein that in humans is encoded by the SLC40A1 gene. Ferroportin is a transmembrane protein that transports iron from the inside of a cell to the outside of the cell. Ferroportin is the only known iron exporter.

Language: English [EN]
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Ferroportin topic overview

The analysis highlights Structure, Function and Role in development as prominent areas in the source structure around Ferroportin.

Related topics
45
Source areas
9
Connected nodes
54
Extracted relationships
125
Related term clusters
20
Bridge connections
54

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Structure · 9 topics
Function · 7 topics
Overview · 7 topics
Role in development · 7 topics
Tissue distribution · 6 topics
Role in iron metabolism · 5 topics
Clinical significance · 2 topics
Protein family · 1 topics
Role in fertility · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
SLC40A1, IREG1, MST079, MSTP079, solute carrier family 40 member 1, MTP1, SLC11A3, FPN1, HFE4
Band
2q32.2 · 1|1 C1.1
Bgee
pancreatic ductal cell · jejunal mucosa · mucosa of ileum · germinal epithelium · trabecular bone
BioGPS
n/a
Chr.
Chromosome 2 (human) · Chromosome 1 (mouse)
Databases
NCBI: entry; OMA: entry

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Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Function

Tissue distribution

Role in development

Role in fertility

Role in iron metabolism

Clinical significance

Protein family

For the semantics nerds

You can skip this section if you’re here for content ideas and keyword inspiration.

Advanced semantic analysis

How Ferroportin connects Entity context

The extracted context around Ferroportin shows recurring relationship patterns in the source. For example, Ferroportin → basolateral plasma membrane, cellular iron ion homeostasis, cytoplasm, cytosol, endothelium development, ferrous iron transmembrane transporter activity, identical protein binding, integral component of membrane, integral component of plasma membrane, intracellular anatomical structure, ion transport, iron ion export across plasma membrane, iron ion homeostasis, iron ion transmembrane transport, iron ion transmembrane transporter activity, iron ion transport, lymphocyte homeostasis, membrane, multicellular organismal iron ion homeostasis, negative regulation of apoptotic process Another extracted example is Ferroportin → cardiac muscle tissue of right atrium, decidua, duodenum, epithelium of small intestine, germinal epithelium, granulocyte, ileum, jejunal mucosa, left colon, liver, medullary collecting duct, mucosa of ileum, palpebral conjunctiva, pancreatic ductal cell, spleen, stroma of bone marrow, superficial temporal artery, tibiofemoral joint, trabecular bone. Use these groups to spot repeated connection types before inspecting the individual relationships.

Ferroportin

Top relations

Gene ontology · 29
Ferroportin → basolateral plasma membrane, cellular iron ion homeostasis, cytoplasm, cytosol, endothelium development, ferrous iron transmembrane transporter activity, identical protein binding, integral component of membrane, integral component of plasma membrane, intracellular anatomical structure, ion transport, iron ion export across plasma membrane, iron ion homeostasis, iron ion transmembrane transport, iron ion transmembrane transporter activity, iron ion transport, lymphocyte homeostasis, membrane, multicellular organismal iron ion homeostasis, negative regulation of apoptotic process
Bgee · 19
Ferroportin → cardiac muscle tissue of right atrium, decidua, duodenum, epithelium of small intestine, germinal epithelium, granulocyte, ileum, jejunal mucosa, left colon, liver, medullary collecting duct, mucosa of ileum, palpebral conjunctiva, pancreatic ductal cell, spleen, stroma of bone marrow, superficial temporal artery, tibiofemoral joint, trabecular bone
RNA expression pattern · 19
Ferroportin → cardiac muscle tissue of right atrium, decidua, duodenum, epithelium of small intestine, germinal epithelium, granulocyte, ileum, jejunal mucosa, left colon, liver, medullary collecting duct, mucosa of ileum, palpebral conjunctiva, pancreatic ductal cell, spleen, stroma of bone marrow, superficial temporal artery, tibiofemoral joint, trabecular bone
related to Structure · 10
Ferroportin → Bdellovibrio, C-terminal, Fpn, H32, Human Fpn, Members, MFS, N-terminal, Recent, When H32
related to Role in development · 7
Ferroportin → E7, Ferroportin-1, Fpn1, Furthermore, Given, Mouse, Slc40a1
related to Clinical significance · 4
Ferroportin → African, Ferroportin Disease, Hemochromatosis, Mutations
related to Function · 4
Ferroportin → Ferroportin-mediated, Fpn, Thus, Xenopus
related to Role in iron metabolism · 4
Ferroportin → Ganz, Hepcidin, IRP, RNA
related to Protein family · 3
Ferroportin → Fpn, Members, Proteobacteria
Band · 2
Ferroportin → 1|1 C1.1, 2q32.2

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

iron fpn gene protein human also family bp slc40a1 hepcidin chr band known chromosome cell mouse transport activity liver function

Ferroportin relationships Subject–Predicate–Object triples

TTTA extracted 125 structured relationships around Ferroportin. Examples in this analysis include Ferroportin → Aliases → SLC40A1, IREG1, MST079, MSTP079, solute carrier family 40 member 1, MTP1, SLC11A3, FPN1, HFE4 and Ferroportin → Band → 2q32.2. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
FerroportinAliasesSLC40A1, IREG1, MST079, MSTP079, solute carrier family 40 member 1, MTP1, SLC11A3, FPN1, HFE41.00infobox
FerroportinBand2q32.21.00infobox
FerroportinBand1|1 C1.11.00infobox
FerroportinBgeepancreatic ductal cell1.00infobox
FerroportinBgeejejunal mucosa1.00infobox
FerroportinBgeemucosa of ileum1.00infobox
FerroportinBgeegerminal epithelium1.00infobox
FerroportinBgeetrabecular bone1.00infobox
FerroportinBgeedecidua1.00infobox
FerroportinBgeecardiac muscle tissue of right atrium1.00infobox
FerroportinBgeepalpebral conjunctiva1.00infobox
FerroportinBgeesuperficial temporal artery1.00infobox
FerroportinBgeeduodenum1.00infobox
FerroportinBgeeepithelium of small intestine1.00infobox
FerroportinBgeemedullary collecting duct1.00infobox
FerroportinBgeestroma of bone marrow1.00infobox
FerroportinBgeespleen1.00infobox
FerroportinBgeetibiofemoral joint1.00infobox
FerroportinBgeeleft colon1.00infobox
FerroportinBgeegranulocyte1.00infobox
FerroportinBgeeliver1.00infobox
FerroportinBgeeileum1.00infobox
FerroportinBioGPSn/a1.00infobox
FerroportinChr.Chromosome 2 (human)1.00infobox
FerroportinChr.Chromosome 1 (mouse)1.00infobox
FerroportinDatabasesNCBI: entry; OMA: entry1.00infobox
FerroportinEnd189,583,758 bp1.00infobox
FerroportinEnd45,965,683 bp1.00infobox
FerroportinEnsemblENSG000001384491.00infobox
FerroportinEntrez300611.00infobox

Related concept clusters Related term clusters

The concept neighborhoods around Ferroportin bring nearby vocabulary together. In this analysis, examples include Iron, Low and Fpn. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Ferroportin
    • Iron
    • Low
    • Fpn
    • Expression
    • Regulated
    • Cell
    • Known
    • Hepcidin
    • Gene
    • Transmembrane
    • Homeostasis
    • Liver
  • ferroportin
    • Iron
    • Low
    • Fpn
    • Expression
    • Regulated
    • Cell
    • Known
    • Hepcidin
    • Gene
    • Transmembrane
    • Homeostasis
    • Liver
  • protein
    • Slc40a1
    • Cell
    • Development
    • Transmembrane
    • Location
    • Structure
    • Chromosome
    • Fpn1
    • Function
    • Mouse
    • Bp
    • Chr
  • gene
    • Slc40a1
    • Mouse
    • Location
    • Protein
    • Chromosome
    • Development
    • Known
    • Bp
    • Chr
    • Human
    • End
    • Structure
  • transmembrane protein
    • Slc40a1
    • Cell
    • Development
    • Transmembrane
    • Location
    • Mrna
    • Response
    • Structure
    • Chromosome
    • Fpn1
    • Function
    • Mouse
  • iron
    • Transport
    • Fpn
    • Human
    • Homeostasis
    • Liver
    • Activity
    • Development
    • Function
    • Hepcidin
    • Protein
    • Transmembrane
    • End
  • cell
    • Transmembrane
    • Protein
    • End
    • Expression
    • Homeostasis
    • Liver
    • Location
    • Mrna
    • Response
    • Structure
    • Activity
    • Band
  • iron homeostasis
    • Transmembrane
    • Transport
    • End
    • Expression
    • Liver
    • Location
    • Mrna
    • Response
    • Structure
    • Fpn
    • Band
    • Chromosome

Connections between topic areas Semantic bridges

For Ferroportin, one of the stronger structural bridges in this analysis connects Ferroportin with Structure. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Ferroportin — Structure · splits 45 ⟂ 10
Ferroportin — Overview · splits 47 ⟂ 8
Ferroportin — Function · splits 47 ⟂ 8
Ferroportin — Role in development · splits 47 ⟂ 8
Ferroportin — Tissue distribution · splits 48 ⟂ 7
Ferroportin — Role in iron metabolism · splits 49 ⟂ 6
Ferroportin — Clinical significance · splits 52 ⟂ 3

Map overview Semantic statistics

Ferroportin

Nodes55
Edges54
Triples125
Avg. degree1.96
Density0.036364
Components1

Source & methodology

TTTA analyzes the structure around Ferroportin to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Structure, Function & Role in development, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Ferroportin · EN edition · Analysis: TopicsToTalkAbout

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