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Silent synapse

In neuroscience, a silent synapse is an excitatory glutamatergic synapse whose postsynaptic membrane contains NMDA-type glutamate receptors but no AMPA-type glutamate receptors. These synapses are named "silent" because normal AMPA receptor-mediated signaling is not present, rendering the synapse inactive under typical conditions. Silent synapses are…

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Overview

Synaptic transmission

Characteristics

Activation

Integration with other topics

Recent Findings

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Map overview Semantic statistics

Silent synapse

Nodes41
Edges40
Triples76
Avg. degree1.95
Density0.04878
Components1

How this topic connects Entity context

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Silent synapse

Top relations

related to Synaptic transmission · 21
Silent synapse → AMPA, AMPAR, AMPARs, Ca2, Calcium, EPSP, However, Mg2, Most, Na, NMDA, NMDAR, NMDARs, Normal, Normally, Silent, The NMDAR, There, This, Though AMPA
related to Activation · 17
Silent synapse → After, AMPA, AMPA Receptor, AMPAR-containing, AMPARs, Ca2, Calmodulin, CaMKII, Early Long Term Potentiation, EPSPs, Hebbian LTP, II, It, Late Long Term Potentiation, Once AMPARs, Silent, When
related to Characteristics · 12
Silent synapse → AMPAR, AMPARs, D-APV, EPSCs, More, Moreover, NMDAR, NMDARs, Silent, Stimulation, The, This
related to Recent Findings · 10
Silent synapse → AMPA, AMPA-type, Chung, Furthermore, Harnett, MIT, NMDA, The, Using, Vardalaki
related to Competing Hypotheses · 9
Silent synapse → AMPA, AMPARs, For, NMDA, NMDARs, Only, Pr, Some, The
related to Integration with other topics · 6
Silent synapse → AMPA, Both, Long Term Potentiation, Long Term Potentiation Many, Silent Synapses, The Role
is a · 1
Silent synapse → excitatory glutamatergic synapse whose postsynaptic membrane contains NMDA-type glutamate receptors but no AMPA-type glutamate receptors

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Important terminology

silent synapses synapse glutamate postsynaptic ampa receptors membrane ampars receptor release nmdars activated glutamatergic depolarization presynaptic nmdar channel magnesium low

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Silent synapseis aexcitatory glutamatergic synapse whose postsynaptic membrane contains NMDA-type glutamate receptors but no AMPA-type glutamate receptors0.90text
Silent synapserelated to ActivationSilent0.60section
Silent synapserelated to ActivationAMPARs0.60section
Silent synapserelated to ActivationAMPA0.60section
Silent synapserelated to ActivationWhen0.60section
Silent synapserelated to ActivationHebbian LTP0.60section
Silent synapserelated to ActivationCa20.60section
Silent synapserelated to ActivationCalmodulin0.60section
Silent synapserelated to ActivationII0.60section
Silent synapserelated to ActivationCaMKII0.60section
Silent synapserelated to ActivationAMPAR-containing0.60section
Silent synapserelated to ActivationOnce AMPARs0.60section

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