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Sequential model

The sequential model (also known as the KNF model) is a theory that describes cooperativity of protein subunits. It postulates that a protein's conformation changes with each binding of a ligand, thus sequentially changing its affinity for the ligand at neighboring binding sites. It gives one explanation for cooperative binding.

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Overview

History

Rules guiding the KNF model

Comparison to the MWC model

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Map overview Semantic statistics

Sequential model

Nodes26
Edges25
Triples20
Avg. degree1.92
Density0.076923
Components1

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Sequential model

Top relations

related to history · 11
Sequential model → Christian Bohr's, Developed, Filmer, KNF, Koshland, MWC, Némethy, The, The KNF, This, Upon
related to Functional differences in hemoglobin · 9
Sequential model → Hemoglobin, It, KNF, MWC, NMR, Nuclear, The, Thus, While

Important terminology Word statistics

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Important terminology

binding model ligand subunits cooperativity affinity knf protein mwc changes conformational conformation change sequential state thus oxygen sites koshland suggests

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Sequential modelrelated to Functional differences in hemoglobinHemoglobin0.60section
Sequential modelrelated to Functional differences in hemoglobinIt0.60section
Sequential modelrelated to Functional differences in hemoglobinWhile0.60section
Sequential modelrelated to Functional differences in hemoglobinNuclear0.60section
Sequential modelrelated to Functional differences in hemoglobinNMR0.60section
Sequential modelrelated to Functional differences in hemoglobinThe0.60section
Sequential modelrelated to Functional differences in hemoglobinThus0.60section
Sequential modelrelated to Functional differences in hemoglobinMWC0.60section
Sequential modelrelated to Functional differences in hemoglobinKNF0.60section
Sequential modelrelated to historyThis0.60section
Sequential modelrelated to historyChristian Bohr's0.60section
Sequential modelrelated to historyThe0.60section

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