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SDHAF2: Regions & Measurement

Succinate dehydrogenase complex assembly factor 2, formerly known as SDH5 and also known as SDH assembly factor 2 or SDHAF2 is a protein that in humans is encoded by the SDHAF2 gene. This gene encodes a mitochondrial protein needed for the flavination of a succinate dehydrogenase complex subunit required for activity of the complex. Mutations in this…

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SDHAF2 topic overview

The analysis highlights Regions and Measurement as prominent areas in the source structure around SDHAF2.

Related topics
40
Source areas
5
Connected nodes
45
Extracted relationships
109
Concept neighborhoods
15
Bridge connections
45

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Clinical significance · 19 topics
Overview · 7 topics
Interactions · 5 topics
Structure · 5 topics
Function · 4 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
SDHAF2, C11orf79, PGL2, SDH5, succinate dehydrogenase complex assembly factor 2
Band
11q12.2 · 19|19 A
Bgee
islet of Langerhans · anterior pituitary · granulocyte · monocyte · mucosa of ileum
BioGPS
n/a
Chr.
Chromosome 11 (human) · Chromosome 19 (mouse)
Databases
NCBI: entry; OMA: entry

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Function

Clinical significance

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How SDHAF2 connects Entity context

The extracted context around SDHAF2 shows recurring relationship patterns in the source. For example, SDHAF2 → anterior pituitary, apex of heart, cardiac muscles, digastric muscle, fetal liver hematopoietic progenitor cell, granulocyte, interventricular septum, islet of Langerhans, left adrenal gland, monocyte, mucosa of ileum, mucosa of transverse colon, myocardium of ventricle, otic placode, otic vesicle, right adrenal cortex, right adrenal gland, saccule, sternocleidomastoid muscle, temporal muscle Another extracted example is SDHAF2 → cytosol, mitochondrial electron transport, succinate to ubiquinone, mitochondrial matrix, mitochondrial respiratory chain complex II assembly, mitochondrion, negative regulation of canonical Wnt signaling pathway, negative regulation of epithelial to mesenchymal transition, nucleolus, protein binding, protein dephosphorylation, protein-FAD linkage, tricarboxylic acid cycle. Use these groups to spot repeated connection types before inspecting the individual relationships.

SDHAF2

Top relations

Bgee · 20
SDHAF2 → anterior pituitary, apex of heart, cardiac muscles, digastric muscle, fetal liver hematopoietic progenitor cell, granulocyte, interventricular septum, islet of Langerhans, left adrenal gland, monocyte, mucosa of ileum, mucosa of transverse colon, myocardium of ventricle, otic placode, otic vesicle, right adrenal cortex, right adrenal gland, saccule, sternocleidomastoid muscle, temporal muscle
RNA expression pattern · 20
SDHAF2 → anterior pituitary, apex of heart, cardiac muscles, digastric muscle, fetal liver hematopoietic progenitor cell, granulocyte, interventricular septum, islet of Langerhans, left adrenal gland, monocyte, mucosa of ileum, mucosa of transverse colon, myocardium of ventricle, otic placode, otic vesicle, right adrenal cortex, right adrenal gland, saccule, sternocleidomastoid muscle, temporal muscle
Gene ontology · 12
SDHAF2 → cytosol, mitochondrial electron transport, succinate to ubiquinone, mitochondrial matrix, mitochondrial respiratory chain complex II assembly, mitochondrion, negative regulation of canonical Wnt signaling pathway, negative regulation of epithelial to mesenchymal transition, nucleolus, protein binding, protein dephosphorylation, protein-FAD linkage, tricarboxylic acid cycle
related to Function · 11
SDHAF2 → FAD, II, It, Knockdown, Krebs, SDH, SDH-dependent, SDH1, SDHA, Such, The SDHAF2
related to Clinical significance · 8
SDHAF2 → Constitutional, DNA, In, Loss, Most, Mutations, Phenotypes, SDH
related to Interactions · 7
SDHAF2 → IMMT, In, SDH, SDHA, SSX2IP, SUCLG2, UBINEDDSUMO1
related to Structure · 5
SDHAF2 → FAD, II, The, The SDHAF2, This
Band · 2
SDHAF2 → 11q12.2, 19|19 A
Chr. · 2
SDHAF2 → Chromosome 11 (human), Chromosome 19 (mouse)
End · 2
SDHAF2 → 10,503,506 bp, 61,446,733 bp

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene complex protein sdh bp band succinate chr human chromosome 11 dehydrogenase paraganglioma function sdha tumor subunit assembly mutations mitochondrial

SDHAF2 relationships Subject–Predicate–Object triples

TTTA extracted 109 structured relationships around SDHAF2. Examples in this analysis include SDHAF2 → Aliases → SDHAF2, C11orf79, PGL2, SDH5, succinate dehydrogenase complex assembly factor 2 and SDHAF2 → Band → 11q12.2. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
SDHAF2AliasesSDHAF2, C11orf79, PGL2, SDH5, succinate dehydrogenase complex assembly factor 21.00infobox
SDHAF2Band11q12.21.00infobox
SDHAF2Band19|19 A1.00infobox
SDHAF2Bgeeislet of Langerhans1.00infobox
SDHAF2Bgeeanterior pituitary1.00infobox
SDHAF2Bgeegranulocyte1.00infobox
SDHAF2Bgeemonocyte1.00infobox
SDHAF2Bgeemucosa of ileum1.00infobox
SDHAF2Bgeeapex of heart1.00infobox
SDHAF2Bgeemucosa of transverse colon1.00infobox
SDHAF2Bgeeright adrenal gland1.00infobox
SDHAF2Bgeeleft adrenal gland1.00infobox
SDHAF2Bgeeright adrenal cortex1.00infobox
SDHAF2Bgeeotic placode1.00infobox
SDHAF2Bgeesaccule1.00infobox
SDHAF2Bgeeinterventricular septum1.00infobox
SDHAF2Bgeeotic vesicle1.00infobox
SDHAF2Bgeesternocleidomastoid muscle1.00infobox
SDHAF2Bgeemyocardium of ventricle1.00infobox
SDHAF2Bgeecardiac muscles1.00infobox
SDHAF2Bgeetemporal muscle1.00infobox
SDHAF2Bgeedigastric muscle1.00infobox
SDHAF2Bgeefetal liver hematopoietic progenitor cell1.00infobox
SDHAF2BioGPSn/a1.00infobox
SDHAF2Chr.Chromosome 11 (human)1.00infobox
SDHAF2Chr.Chromosome 19 (mouse)1.00infobox
SDHAF2DatabasesNCBI: entry; OMA: entry1.00infobox
SDHAF2End61,446,733 bp1.00infobox
SDHAF2End10,503,506 bp1.00infobox
SDHAF2EnsemblENSG000001679851.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around SDHAF2 bring nearby vocabulary together. In this analysis, examples include Protein, Gene and Function. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • protein
    • Succinate
    • Mitochondrial
    • Gene
    • Sdhaf2
    • Encodes
    • Ii
    • Sdh
    • Associated
    • End
    • Mouse
    • Required
    • Sdh5
  • gene
    • Succinate
    • Protein
    • Sdhaf2
    • Location
    • Mitochondrial
    • Mutations
    • Chromosome
    • Human
    • Bp
    • Chr
    • Associated
    • Encodes
  • succinate dehydrogenase complex
    • Dehydrogenase
    • Succinate
    • Assembly
    • Mitochondrial
    • Sdh
    • Complex
    • Encodes
    • Factor
    • Protein
    • Sdh5
    • Sdhaf2
    • Gene
  • tumor suppressor gene
    • Succinate
    • Protein
    • Sdhaf2
    • Location
    • Mitochondrial
    • Mutations
    • Chromosome
    • Human
    • Bp
    • Chr
    • Also
    • Formerly
  • protein–protein interactions
    • Succinate
    • Mitochondrial
    • Gene
    • Sdhaf2
    • Encodes
    • Ii
    • Sdh
    • Associated
    • End
    • Mouse
    • Required
    • Sdh5
  • SDHAF2
    • Protein
    • Gene
    • Function
    • Succinate
    • Sdha
    • Ii
    • Location
    • Mitochondrial
    • Chromosome
    • Human
    • Subunit
    • Tumor
  • sdhaf2
    • Protein
    • Gene
    • Function
    • Succinate
    • Sdha
    • Ii
    • Location
    • Mitochondrial
    • Chromosome
    • Human
    • Subunit
    • Tumor
  • function
    • Location
    • Sdhaf2
    • Chromosome
    • Human
    • Bp
    • Chr
    • Succinate
    • End
    • Mouse
    • Sdh
    • Sdh5
    • Gene

Connections between topic areas Semantic bridges

For SDHAF2, one of the stronger structural bridges in this analysis connects SDHAF2 with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
SDHAF2Clinical significance · splits 26 ⟂ 20
SDHAF2Overview · splits 38 ⟂ 8
SDHAF2Structure · splits 40 ⟂ 6
SDHAF2Interactions · splits 40 ⟂ 6
SDHAF2Function · splits 41 ⟂ 5

Map overview Semantic statistics

SDHAF2

Nodes46
Edges45
Triples109
Avg. degree1.96
Density0.043478
Components1

Source & methodology

TTTA analyzes the structure around SDHAF2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Regions & Measurement, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — SDHAF2 · EN edition · Analysis: TopicsToTalkAbout

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