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SDHAF2

Succinate dehydrogenase complex assembly factor 2, formerly known as SDH5 and also known as SDH assembly factor 2 or SDHAF2 is a protein that in humans is encoded by the SDHAF2 gene. This gene encodes a mitochondrial protein needed for the flavination of a succinate dehydrogenase complex subunit required for activity of the complex. Mutations in this…

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Aliases
SDHAF2, C11orf79, PGL2, SDH5, succinate dehydrogenase complex assembly factor 2
Band
11q12.2 · 19|19 A
Bgee
islet of Langerhans · anterior pituitary · granulocyte · monocyte · mucosa of ileum
BioGPS
n/a
Chr.
Chromosome 11 (human) · Chromosome 19 (mouse)
Databases
NCBI: entry; OMA: entry

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Advanced semantic analysis

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Map overview Semantic statistics

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SDHAF2

Nodes46
Edges45
Triples109
Avg. degree1.96
Density0.043478
Components1

How this topic connects Entity context

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SDHAF2

Top relations

Bgee · 20
SDHAF2 → anterior pituitary, apex of heart, cardiac muscles, digastric muscle, fetal liver hematopoietic progenitor cell, granulocyte, interventricular septum, islet of Langerhans, left adrenal gland, monocyte, mucosa of ileum, mucosa of transverse colon, myocardium of ventricle, otic placode, otic vesicle, right adrenal cortex, right adrenal gland, saccule, sternocleidomastoid muscle, temporal muscle
RNA expression pattern · 20
SDHAF2 → anterior pituitary, apex of heart, cardiac muscles, digastric muscle, fetal liver hematopoietic progenitor cell, granulocyte, interventricular septum, islet of Langerhans, left adrenal gland, monocyte, mucosa of ileum, mucosa of transverse colon, myocardium of ventricle, otic placode, otic vesicle, right adrenal cortex, right adrenal gland, saccule, sternocleidomastoid muscle, temporal muscle
Gene ontology · 12
SDHAF2 → cytosol, mitochondrial electron transport, succinate to ubiquinone, mitochondrial matrix, mitochondrial respiratory chain complex II assembly, mitochondrion, negative regulation of canonical Wnt signaling pathway, negative regulation of epithelial to mesenchymal transition, nucleolus, protein binding, protein dephosphorylation, protein-FAD linkage, tricarboxylic acid cycle
related to Function · 11
SDHAF2 → FAD, II, It, Knockdown, Krebs, SDH, SDH-dependent, SDH1, SDHA, Such, The SDHAF2
related to Clinical significance · 8
SDHAF2 → Constitutional, DNA, In, Loss, Most, Mutations, Phenotypes, SDH
related to Interactions · 7
SDHAF2 → IMMT, In, SDH, SDHA, SSX2IP, SUCLG2, UBINEDDSUMO1
related to Structure · 5
SDHAF2 → FAD, II, The, The SDHAF2, This
Band · 2
SDHAF2 → 11q12.2, 19|19 A
Chr. · 2
SDHAF2 → Chromosome 11 (human), Chromosome 19 (mouse)
End · 2
SDHAF2 → 10,503,506 bp, 61,446,733 bp

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Important terminology

gene complex protein sdh bp band succinate chr human chromosome 11 dehydrogenase paraganglioma function sdha tumor subunit assembly mutations mitochondrial

Entity relationships Subject–Predicate–Object triples

Extracted RDF-like relationships with confidence and source. The table includes structured facts and lower-confidence contextual relations.
SubjectPredicateObjectConfidenceSrc
SDHAF2AliasesSDHAF2, C11orf79, PGL2, SDH5, succinate dehydrogenase complex assembly factor 21.00infobox
SDHAF2Band11q12.21.00infobox
SDHAF2Band19|19 A1.00infobox
SDHAF2Bgeeislet of Langerhans1.00infobox
SDHAF2Bgeeanterior pituitary1.00infobox
SDHAF2Bgeegranulocyte1.00infobox
SDHAF2Bgeemonocyte1.00infobox
SDHAF2Bgeemucosa of ileum1.00infobox
SDHAF2Bgeeapex of heart1.00infobox
SDHAF2Bgeemucosa of transverse colon1.00infobox
SDHAF2Bgeeright adrenal gland1.00infobox
SDHAF2Bgeeleft adrenal gland1.00infobox
SDHAF2Bgeeright adrenal cortex1.00infobox
SDHAF2Bgeeotic placode1.00infobox
SDHAF2Bgeesaccule1.00infobox
SDHAF2Bgeeinterventricular septum1.00infobox
SDHAF2Bgeeotic vesicle1.00infobox
SDHAF2Bgeesternocleidomastoid muscle1.00infobox
SDHAF2Bgeemyocardium of ventricle1.00infobox
SDHAF2Bgeecardiac muscles1.00infobox
SDHAF2Bgeetemporal muscle1.00infobox
SDHAF2Bgeedigastric muscle1.00infobox
SDHAF2Bgeefetal liver hematopoietic progenitor cell1.00infobox
SDHAF2BioGPSn/a1.00infobox
SDHAF2Chr.Chromosome 11 (human)1.00infobox
SDHAF2Chr.Chromosome 19 (mouse)1.00infobox
SDHAF2DatabasesNCBI: entry; OMA: entry1.00infobox
SDHAF2End61,446,733 bp1.00infobox
SDHAF2End10,503,506 bp1.00infobox
SDHAF2EnsemblENSG000001679851.00infobox

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