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SAMHD1

SAM domain and HD domain-containing protein 1 is a protein that in humans is encoded by the SAMHD1 gene. SAMHD1 is a cellular enzyme, responsible for blocking replication of HIV in dendritic cells, macrophages, monocytes and resting CD4+ T lymphocytes. It is an enzyme that exhibits phosphohydrolase activity, converting deoxynucleoside triphosphates…

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Aliases
SAMHD1, CHBL2, DCIP, HDDC1, MOP-5, SBBI88, SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1, hSAMHD1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2E8O, 3U1N, 4BZB, 4BZC, 4CC9, 4MZ7, 4Q7H, 4QFX, 4QFY, 4QFZ, 4QG0, 4QG1, 4QG2, 4QG4, 4RXO, 4RXP, 4RXQ, 4RXR,…
Band
20q11.23 · 2|2 H1
Bgee
monocyte · pericardium · epithelium of nasopharynx · bronchial epithelial cell · lower lobe of lung
BioGPS
More reference expression data
Chr.
Chromosome 20 (human) · Chromosome 2 (mouse)

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Overview

Gene

Structure

Function

Role in disease

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Map overview Semantic statistics

SAMHD1

Nodes29
Edges28
Triples165
Avg. degree1.93
Density0.068966
Components1

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SAMHD1

Top relations

Gene ontology · 41
SAMHD1 → catalytic activity, cellular response to DNA damage stimulus, chromosome, dATP catabolic process, defense response to virus, deoxyribonucleotide catabolic process, dGTP binding, dGTP catabolic process, dGTPase activity, DNA repair, DNA replication, DNA strand resection involved in replication fork processing, double-strand break repair via homologous recombination, GTP binding, hydrolase activity, identical protein binding, immune response, immune system process, innate immune response, intracellular anatomical structure
Bgee · 20
SAMHD1 → blood, bronchial epithelial cell, decidua, epithelium of nasopharynx, gastrula, granulocyte, jejunum, lower lobe of lung, mesenteric lymph nodes, monocyte, palpebral conjunctiva, pericardium, spleen, stroma of bone marrow, superficial temporal artery, tail of embryo, tibial nerve, trigeminal ganglion, visceral pleura, yolk sac
RNA expression pattern · 20
SAMHD1 → blood, bronchial epithelial cell, decidua, epithelium of nasopharynx, gastrula, granulocyte, jejunum, lower lobe of lung, mesenteric lymph nodes, monocyte, palpebral conjunctiva, pericardium, spleen, stroma of bone marrow, superficial temporal artery, tail of embryo, tibial nerve, trigeminal ganglion, visceral pleura, yolk sac
related to External links · 11
SAMHD1 → Aicardi-Goutieres, Aicardi-Goutières SyndromeOMIM, GeneReviews/NCBI/NIH/UW, Human Deoxynucleoside, Mouse Deoxynucleoside, Overview, PDB, PDBe-KB, Q60710, Q9Y3Z3, UniProt
related to Restriction of viral infection · 11
SAMHD1 → A2/CDK1, CD4, Conversely, DNA/RNA, DNAs, HIV-1, Phosphorylated SAMHD1, Retroviral, RNA, RNAs, The
related to Expression modulation and antimetabolite degradation in cancer cells · 10
SAMHD1 → Antimetabolites, Finally, First, For, Non-adherent, Regulation, Second, Third, Viral, Vpx
related to Function · 9
SAMHD1 → AGS, Aicardi, DC, Goutières, HIV-1, IFN, Monocytes, Mutations, Vpx
related to Nomenclature · 8
SAMHD1 → AGS5, Aicardi- Goutières, Dendritic, HD, IFNG-induced, Interferon-gamma-inducible, Monocyte, The SAMHD1
related to Gene · 4
SAMHD1 → IFN-γ-induced, Mg11, The, The SAMHD1
related to Structure · 4
SAMHD1 → In, SAM, Sterile, The SAMHD1

Important terminology Word statistics

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Important terminology

protein cells activity gene human bp chromosome dna shown 20 hd triphosphohydrolase chr hiv-1 band also syndrome infection domain cellular

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
SAMHD1AliasesSAMHD1, CHBL2, DCIP, HDDC1, MOP-5, SBBI88, SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1, hSAMHD11.00infobox
SAMHD1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2E8O, 3U1N, 4BZB, 4BZC, 4CC9, 4MZ7, 4Q7H, 4QFX, 4QFY, 4QFZ, 4QG0, 4QG1, 4QG2, 4QG4, 4RXO, 4RXP, 4RXQ, 4RXR,…1.00infobox
SAMHD1Band20q11.231.00infobox
SAMHD1Band2|2 H11.00infobox
SAMHD1Bgeemonocyte1.00infobox
SAMHD1Bgeepericardium1.00infobox
SAMHD1Bgeeepithelium of nasopharynx1.00infobox
SAMHD1Bgeebronchial epithelial cell1.00infobox
SAMHD1Bgeelower lobe of lung1.00infobox
SAMHD1Bgeepalpebral conjunctiva1.00infobox
SAMHD1Bgeetibial nerve1.00infobox
SAMHD1Bgeetrigeminal ganglion1.00infobox
SAMHD1Bgeevisceral pleura1.00infobox
SAMHD1Bgeesuperficial temporal artery1.00infobox
SAMHD1Bgeegranulocyte1.00infobox
SAMHD1Bgeegastrula1.00infobox
SAMHD1Bgeespleen1.00infobox
SAMHD1Bgeemesenteric lymph nodes1.00infobox
SAMHD1Bgeeblood1.00infobox
SAMHD1Bgeestroma of bone marrow1.00infobox
SAMHD1Bgeeyolk sac1.00infobox
SAMHD1Bgeedecidua1.00infobox
SAMHD1Bgeetail of embryo1.00infobox
SAMHD1Bgeejejunum1.00infobox
SAMHD1BioGPSMore reference expression data1.00infobox
SAMHD1Chr.Chromosome 20 (human)1.00infobox
SAMHD1Chr.Chromosome 2 (mouse)1.00infobox
SAMHD1DatabasesNCBI: entry; OMA: entry1.00infobox
SAMHD1End36,951,893 bp1.00infobox
SAMHD1End156,977,185 bp1.00infobox

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