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SAMHD1: Overview, Structure & Gene

SAM domain and HD domain-containing protein 1 is a protein that in humans is encoded by the SAMHD1 gene. SAMHD1 is a cellular enzyme, responsible for blocking replication of HIV in dendritic cells, macrophages, monocytes and resting CD4+ T lymphocytes. It is an enzyme that exhibits phosphohydrolase activity, converting deoxynucleoside triphosphates…

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SAMHD1 topic overview

The analysis highlights Overview, Structure and Gene as prominent areas in the source structure around SAMHD1.

Related topics
23
Source areas
5
Connected nodes
28
Extracted relationships
165
Concept neighborhoods
13
Bridge connections
28

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 16 topics
Structure · 4 topics
Function · 1 topics
Gene · 1 topics
Role in disease · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
SAMHD1, CHBL2, DCIP, HDDC1, MOP-5, SBBI88, SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1, hSAMHD1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2E8O, 3U1N, 4BZB, 4BZC, 4CC9, 4MZ7, 4Q7H, 4QFX, 4QFY, 4QFZ, 4QG0, 4QG1, 4QG2, 4QG4, 4RXO, 4RXP, 4RXQ, 4RXR,…
Band
20q11.23 · 2|2 H1
Bgee
monocyte · pericardium · epithelium of nasopharynx · bronchial epithelial cell · lower lobe of lung
BioGPS
More reference expression data
Chr.
Chromosome 20 (human) · Chromosome 2 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Gene

Structure

Function

Role in disease

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How SAMHD1 connects Entity context

The extracted context around SAMHD1 shows recurring relationship patterns in the source. For example, SAMHD1 → catalytic activity, cellular response to DNA damage stimulus, chromosome, dATP catabolic process, defense response to virus, deoxyribonucleotide catabolic process, dGTP binding, dGTP catabolic process, dGTPase activity, DNA repair, DNA replication, DNA strand resection involved in replication fork processing, double-strand break repair via homologous recombination, GTP binding, hydrolase activity, identical protein binding, immune response, immune system process, innate immune response, intracellular anatomical structure Another extracted example is SAMHD1 → blood, bronchial epithelial cell, decidua, epithelium of nasopharynx, gastrula, granulocyte, jejunum, lower lobe of lung, mesenteric lymph nodes, monocyte, palpebral conjunctiva, pericardium, spleen, stroma of bone marrow, superficial temporal artery, tail of embryo, tibial nerve, trigeminal ganglion, visceral pleura, yolk sac. Use these groups to spot repeated connection types before inspecting the individual relationships.

SAMHD1

Top relations

Gene ontology · 41
SAMHD1 → catalytic activity, cellular response to DNA damage stimulus, chromosome, dATP catabolic process, defense response to virus, deoxyribonucleotide catabolic process, dGTP binding, dGTP catabolic process, dGTPase activity, DNA repair, DNA replication, DNA strand resection involved in replication fork processing, double-strand break repair via homologous recombination, GTP binding, hydrolase activity, identical protein binding, immune response, immune system process, innate immune response, intracellular anatomical structure
Bgee · 20
SAMHD1 → blood, bronchial epithelial cell, decidua, epithelium of nasopharynx, gastrula, granulocyte, jejunum, lower lobe of lung, mesenteric lymph nodes, monocyte, palpebral conjunctiva, pericardium, spleen, stroma of bone marrow, superficial temporal artery, tail of embryo, tibial nerve, trigeminal ganglion, visceral pleura, yolk sac
RNA expression pattern · 20
SAMHD1 → blood, bronchial epithelial cell, decidua, epithelium of nasopharynx, gastrula, granulocyte, jejunum, lower lobe of lung, mesenteric lymph nodes, monocyte, palpebral conjunctiva, pericardium, spleen, stroma of bone marrow, superficial temporal artery, tail of embryo, tibial nerve, trigeminal ganglion, visceral pleura, yolk sac
related to External links · 11
SAMHD1 → Aicardi-Goutieres, Aicardi-Goutières SyndromeOMIM, GeneReviews/NCBI/NIH/UW, Human Deoxynucleoside, Mouse Deoxynucleoside, Overview, PDB, PDBe-KB, Q60710, Q9Y3Z3, UniProt
related to Restriction of viral infection · 11
SAMHD1 → A2/CDK1, CD4, Conversely, DNA/RNA, DNAs, HIV-1, Phosphorylated SAMHD1, Retroviral, RNA, RNAs, The
related to Expression modulation and antimetabolite degradation in cancer cells · 10
SAMHD1 → Antimetabolites, Finally, First, For, Non-adherent, Regulation, Second, Third, Viral, Vpx
related to Function · 9
SAMHD1 → AGS, Aicardi, DC, Goutières, HIV-1, IFN, Monocytes, Mutations, Vpx
related to Nomenclature · 8
SAMHD1 → AGS5, Aicardi- Goutières, Dendritic, HD, IFNG-induced, Interferon-gamma-inducible, Monocyte, The SAMHD1
related to Gene · 4
SAMHD1 → IFN-γ-induced, Mg11, The, The SAMHD1
related to Structure · 4
SAMHD1 → In, SAM, Sterile, The SAMHD1

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

protein cells activity gene human bp chromosome dna shown 20 hd triphosphohydrolase chr hiv-1 band also syndrome infection domain cellular

SAMHD1 relationships Subject–Predicate–Object triples

TTTA extracted 165 structured relationships around SAMHD1. Examples in this analysis include SAMHD1 → Aliases → SAMHD1, CHBL2, DCIP, HDDC1, MOP-5, SBBI88, SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1, hSAMHD1 and SAMHD1 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2E8O, 3U1N, 4BZB, 4BZC, 4CC9, 4MZ7, 4Q7H, 4QFX, 4QFY, 4QFZ, 4QG0, 4QG1, 4QG2, 4QG4, 4RXO, 4RXP, 4RXQ, 4RXR,…. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
SAMHD1AliasesSAMHD1, CHBL2, DCIP, HDDC1, MOP-5, SBBI88, SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1, hSAMHD11.00infobox
SAMHD1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2E8O, 3U1N, 4BZB, 4BZC, 4CC9, 4MZ7, 4Q7H, 4QFX, 4QFY, 4QFZ, 4QG0, 4QG1, 4QG2, 4QG4, 4RXO, 4RXP, 4RXQ, 4RXR,…1.00infobox
SAMHD1Band20q11.231.00infobox
SAMHD1Band2|2 H11.00infobox
SAMHD1Bgeemonocyte1.00infobox
SAMHD1Bgeepericardium1.00infobox
SAMHD1Bgeeepithelium of nasopharynx1.00infobox
SAMHD1Bgeebronchial epithelial cell1.00infobox
SAMHD1Bgeelower lobe of lung1.00infobox
SAMHD1Bgeepalpebral conjunctiva1.00infobox
SAMHD1Bgeetibial nerve1.00infobox
SAMHD1Bgeetrigeminal ganglion1.00infobox
SAMHD1Bgeevisceral pleura1.00infobox
SAMHD1Bgeesuperficial temporal artery1.00infobox
SAMHD1Bgeegranulocyte1.00infobox
SAMHD1Bgeegastrula1.00infobox
SAMHD1Bgeespleen1.00infobox
SAMHD1Bgeemesenteric lymph nodes1.00infobox
SAMHD1Bgeeblood1.00infobox
SAMHD1Bgeestroma of bone marrow1.00infobox
SAMHD1Bgeeyolk sac1.00infobox
SAMHD1Bgeedecidua1.00infobox
SAMHD1Bgeetail of embryo1.00infobox
SAMHD1Bgeejejunum1.00infobox
SAMHD1BioGPSMore reference expression data1.00infobox
SAMHD1Chr.Chromosome 20 (human)1.00infobox
SAMHD1Chr.Chromosome 2 (mouse)1.00infobox
SAMHD1DatabasesNCBI: entry; OMA: entry1.00infobox
SAMHD1End36,951,893 bp1.00infobox
SAMHD1End156,977,185 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around SAMHD1 bring nearby vocabulary together. In this analysis, examples include Infection, Also and Syndrome. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • SAMHD1
    • Infection
    • Also
    • Syndrome
    • Triphosphohydrolase
    • Dna
    • Chromosome
    • Hiv-1
    • Human
    • Shown
    • Metabolism
    • Pdb
    • Uniprot
  • samhd1
    • Infection
    • Also
    • Syndrome
    • Triphosphohydrolase
    • Dna
    • Chromosome
    • Hiv-1
    • Human
    • Shown
    • Metabolism
    • Pdb
    • Uniprot
  • protein
    • Samhd1
    • Gene
    • Cellular
    • Sam
    • Bp
    • Chromosome
    • Human
    • Syndrome
    • Cells
    • Damage
    • Location
    • Metabolism
  • gene
    • Chromosome
    • Location
    • Chr
    • Bp
    • Hd
    • Human
    • Syndrome
    • Metabolism
    • Mouse
    • Band
    • Cellular
    • Sam
  • dendritic cells
    • Samhd1
    • Activity
    • Hiv-1
    • Infection
    • Cellular
    • Restriction
    • Protein
    • Triphosphohydrolase
    • Enzyme
    • Damage
    • Dntps
    • Location
  • deoxynucleoside triphosphates
    • Pdb
    • Available
    • Triphosphate
    • Triphosphohydrolase
    • Uniprot
    • Human
    • Syndrome
    • Enzyme
    • Dntps
    • Location
    • Metabolism
    • Mouse
  • dna
    • Repair
    • Triphosphohydrolase
    • Damage
    • Metabolism
    • Intracellular
    • Nuclease
    • Replication
    • Domain
    • Hd
    • Human
    • Location
    • Mouse
  • dna repair
    • Repair
    • Damage
    • Triphosphohydrolase
    • Metabolism
    • Intracellular
    • Nuclease
    • Replication
    • Domain
    • Hd
    • Human
    • Location
    • Mouse

Connections between topic areas Semantic bridges

For SAMHD1, one of the stronger structural bridges in this analysis connects SAMHD1 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
SAMHD1Overview · splits 12 ⟂ 17
SAMHD1Structure · splits 24 ⟂ 5

Map overview Semantic statistics

SAMHD1

Nodes29
Edges28
Triples165
Avg. degree1.93
Density0.068966
Components1

Source & methodology

TTTA analyzes the structure around SAMHD1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Overview, Structure & Gene, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — SAMHD1 · EN edition · Analysis: TopicsToTalkAbout

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