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SAM domain and HD domain-containing protein 1 is a protein that in humans is encoded by the SAMHD1 gene. SAMHD1 is a cellular enzyme, responsible for blocking replication of HIV in dendritic cells, macrophages, monocytes and resting CD4+ T lymphocytes. It is an enzyme that exhibits phosphohydrolase activity, converting deoxynucleoside triphosphates…
The analysis highlights Overview, Structure and Gene as prominent areas in the source structure around SAMHD1.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around SAMHD1 shows recurring relationship patterns in the source. For example, SAMHD1 → catalytic activity, cellular response to DNA damage stimulus, chromosome, dATP catabolic process, defense response to virus, deoxyribonucleotide catabolic process, dGTP binding, dGTP catabolic process, dGTPase activity, DNA repair, DNA replication, DNA strand resection involved in replication fork processing, double-strand break repair via homologous recombination, GTP binding, hydrolase activity, identical protein binding, immune response, immune system process, innate immune response, intracellular anatomical structure Another extracted example is SAMHD1 → blood, bronchial epithelial cell, decidua, epithelium of nasopharynx, gastrula, granulocyte, jejunum, lower lobe of lung, mesenteric lymph nodes, monocyte, palpebral conjunctiva, pericardium, spleen, stroma of bone marrow, superficial temporal artery, tail of embryo, tibial nerve, trigeminal ganglion, visceral pleura, yolk sac. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
protein cells activity gene human bp chromosome dna shown 20 hd triphosphohydrolase chr hiv-1 band also syndrome infection domain cellular
TTTA extracted 165 structured relationships around SAMHD1. Examples in this analysis include SAMHD1 → Aliases → SAMHD1, CHBL2, DCIP, HDDC1, MOP-5, SBBI88, SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1, hSAMHD1 and SAMHD1 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2E8O, 3U1N, 4BZB, 4BZC, 4CC9, 4MZ7, 4Q7H, 4QFX, 4QFY, 4QFZ, 4QG0, 4QG1, 4QG2, 4QG4, 4RXO, 4RXP, 4RXQ, 4RXR,…. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| SAMHD1 | Aliases | SAMHD1, CHBL2, DCIP, HDDC1, MOP-5, SBBI88, SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1, hSAMHD1 | 1.00 | infobox |
| SAMHD1 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2E8O, 3U1N, 4BZB, 4BZC, 4CC9, 4MZ7, 4Q7H, 4QFX, 4QFY, 4QFZ, 4QG0, 4QG1, 4QG2, 4QG4, 4RXO, 4RXP, 4RXQ, 4RXR,… | 1.00 | infobox |
| SAMHD1 | Band | 20q11.23 | 1.00 | infobox |
| SAMHD1 | Band | 2|2 H1 | 1.00 | infobox |
| SAMHD1 | Bgee | monocyte | 1.00 | infobox |
| SAMHD1 | Bgee | pericardium | 1.00 | infobox |
| SAMHD1 | Bgee | epithelium of nasopharynx | 1.00 | infobox |
| SAMHD1 | Bgee | bronchial epithelial cell | 1.00 | infobox |
| SAMHD1 | Bgee | lower lobe of lung | 1.00 | infobox |
| SAMHD1 | Bgee | palpebral conjunctiva | 1.00 | infobox |
| SAMHD1 | Bgee | tibial nerve | 1.00 | infobox |
| SAMHD1 | Bgee | trigeminal ganglion | 1.00 | infobox |
| SAMHD1 | Bgee | visceral pleura | 1.00 | infobox |
| SAMHD1 | Bgee | superficial temporal artery | 1.00 | infobox |
| SAMHD1 | Bgee | granulocyte | 1.00 | infobox |
| SAMHD1 | Bgee | gastrula | 1.00 | infobox |
| SAMHD1 | Bgee | spleen | 1.00 | infobox |
| SAMHD1 | Bgee | mesenteric lymph nodes | 1.00 | infobox |
| SAMHD1 | Bgee | blood | 1.00 | infobox |
| SAMHD1 | Bgee | stroma of bone marrow | 1.00 | infobox |
| SAMHD1 | Bgee | yolk sac | 1.00 | infobox |
| SAMHD1 | Bgee | decidua | 1.00 | infobox |
| SAMHD1 | Bgee | tail of embryo | 1.00 | infobox |
| SAMHD1 | Bgee | jejunum | 1.00 | infobox |
| SAMHD1 | BioGPS | More reference expression data | 1.00 | infobox |
| SAMHD1 | Chr. | Chromosome 20 (human) | 1.00 | infobox |
| SAMHD1 | Chr. | Chromosome 2 (mouse) | 1.00 | infobox |
| SAMHD1 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| SAMHD1 | End | 36,951,893 bp | 1.00 | infobox |
| SAMHD1 | End | 156,977,185 bp | 1.00 | infobox |
The concept neighborhoods around SAMHD1 bring nearby vocabulary together. In this analysis, examples include Infection, Also and Syndrome. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For SAMHD1, one of the stronger structural bridges in this analysis connects SAMHD1 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around SAMHD1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Overview, Structure & Gene, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — SAMHD1 · EN edition · Analysis: TopicsToTalkAbout