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Resistin: Clinical significance, Discovery and structure & Function

Resistin, also known as adipose tissue-specific secretory factor (ADSF) or C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein (XCP1), is a cysteine-rich peptide hormone that is derived from adipose tissue and, in humans, is encoded by the RETN gene.

Language: English [EN]
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Resistin topic overview

The analysis highlights Clinical significance, Discovery and structure and Function as prominent areas in the source structure around Resistin.

Related topics
59
Source areas
4
Connected nodes
63
Extracted relationships
146
Concept neighborhoods
18
Bridge connections
63

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Clinical significance · 17 topics
Overview · 15 topics
Discovery and structure · 14 topics
Function · 13 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
RETN, ADSF, FIZZ3, RETN1, RSTN, XCP1, resistin
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1LV6
Band
19p13.2 · 8 A1.1|8 1.92 cM
Bgee
bone marrow · bone marrow cell · monocyte · trabecular bone · granulocyte
BioGPS
More reference expression data
Chr.
Chromosome 19 (human) · Chromosome 8 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Discovery and structure

Function

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Resistin connects Entity context

The extracted context around Resistin shows recurring relationship patterns in the source. For example, Resistin → ageing, azurophil granule lumen, biological process, extracellular exosome, extracellular region, extracellular space, fat cell differentiation, hormone activity, negative regulation of feeding behavior, neutrophil degranulation, nucleus, positive regulation of collagen metabolic process, positive regulation of progesterone secretion, positive regulation of smooth muscle cell migration, positive regulation of smooth muscle cell proliferation, positive regulation of synaptic transmission, regulation of signaling receptor activity, response to insulin, response to mechanical stimulus, signal transduction Another extracted example is Resistin → ankle joint, blood, bone marrow, bone marrow cell, brown adipose tissue, gastric mucosa, granulocyte, intercostal muscle, lactiferous gland, mesenteric lymph nodes, monocyte, right lung, skin of abdomen, spleen, subcutaneous adipose tissue, trabecular bone, tunica adventitia of aorta, tunica media of zone of aorta, upper lobe of left lung, white adipose tissue. Use these groups to spot repeated connection types before inspecting the individual relationships.

Resistin

Top relations

Gene ontology · 21
Resistin → ageing, azurophil granule lumen, biological process, extracellular exosome, extracellular region, extracellular space, fat cell differentiation, hormone activity, negative regulation of feeding behavior, neutrophil degranulation, nucleus, positive regulation of collagen metabolic process, positive regulation of progesterone secretion, positive regulation of smooth muscle cell migration, positive regulation of smooth muscle cell proliferation, positive regulation of synaptic transmission, regulation of signaling receptor activity, response to insulin, response to mechanical stimulus, signal transduction
Bgee · 20
Resistin → ankle joint, blood, bone marrow, bone marrow cell, brown adipose tissue, gastric mucosa, granulocyte, intercostal muscle, lactiferous gland, mesenteric lymph nodes, monocyte, right lung, skin of abdomen, spleen, subcutaneous adipose tissue, trabecular bone, tunica adventitia of aorta, tunica media of zone of aorta, upper lobe of left lung, white adipose tissue
RNA expression pattern · 20
Resistin → ankle joint, blood, bone marrow, bone marrow cell, brown adipose tissue, gastric mucosa, granulocyte, intercostal muscle, lactiferous gland, mesenteric lymph nodes, monocyte, right lung, skin of abdomen, spleen, subcutaneous adipose tissue, trabecular bone, tunica adventitia of aorta, tunica media of zone of aorta, upper lobe of left lung, white adipose tissue
related to Inflammation · 14
Resistin → Beyond, During, IL-12, IL-6, Interleukin-12, It, Likewise, NF-κB-mediated, One, ROS, TNF-α, Together, Toll-like, VCAM1
related to Function · 11
Resistin → Beyond, CAP1, IL-1β, IL-6, In, LPS, NETs, Notably, This, TLR4, TNF-α
related to Discovery and structure · 9
Resistin → C-terminal, Each, In, N-terminal, Specifically, Subsequent, The, These, This
related to Obesity and insulin resistance · 9
Resistin → Although, Conversely, If, Much, On, Several, Specifically, T2DM, This
related to External links · 3
Resistin → Medicine Medical Subject Headings, MeSH, National Library
Band · 2
Resistin → 19p13.2, 8 A1.1|8 1.92 cM
Chr. · 2
Resistin → Chromosome 19 (human), Chromosome 8 (mouse)

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

insulin levels hormone inflammation human bp obesity resistance adipose also tissue chr band gene t2dm chromosome 19 retn serum humans

Resistin relationships Subject–Predicate–Object triples

TTTA extracted 146 structured relationships around Resistin. Examples in this analysis include Resistin → Aliases → RETN, ADSF, FIZZ3, RETN1, RSTN, XCP1, resistin and Resistin → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1LV6. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
ResistinAliasesRETN, ADSF, FIZZ3, RETN1, RSTN, XCP1, resistin1.00infobox
ResistinAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1LV61.00infobox
ResistinBand19p13.21.00infobox
ResistinBand8 A1.1|8 1.92 cM1.00infobox
ResistinBgeebone marrow1.00infobox
ResistinBgeebone marrow cell1.00infobox
ResistinBgeemonocyte1.00infobox
ResistinBgeetrabecular bone1.00infobox
ResistinBgeegranulocyte1.00infobox
ResistinBgeeright lung1.00infobox
ResistinBgeeupper lobe of left lung1.00infobox
ResistinBgeeblood1.00infobox
ResistinBgeespleen1.00infobox
ResistinBgeegastric mucosa1.00infobox
ResistinBgeewhite adipose tissue1.00infobox
ResistinBgeesubcutaneous adipose tissue1.00infobox
ResistinBgeetunica adventitia of aorta1.00infobox
ResistinBgeelactiferous gland1.00infobox
ResistinBgeeintercostal muscle1.00infobox
ResistinBgeetunica media of zone of aorta1.00infobox
ResistinBgeemesenteric lymph nodes1.00infobox
ResistinBgeebrown adipose tissue1.00infobox
ResistinBgeeankle joint1.00infobox
ResistinBgeeskin of abdomen1.00infobox
ResistinBioGPSMore reference expression data1.00infobox
ResistinChr.Chromosome 19 (human)1.00infobox
ResistinChr.Chromosome 8 (mouse)1.00infobox
ResistinDatabasesNCBI: entry; OMA: entry1.00infobox
ResistinEnd7,670,455 bp1.00infobox
ResistinEnd3,710,110 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Resistin bring nearby vocabulary together. In this analysis, examples include Levels, Insulin and Resistance. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Resistin
    • Levels
    • Insulin
    • Resistance
    • Hormone
    • Inflammation
    • Obesity
    • Cells
    • Correlation
    • Humans
    • Role
    • Serum
    • Tissue
  • resistin
    • Levels
    • Insulin
    • Resistance
    • Hormone
    • Inflammation
    • Obesity
    • Cells
    • Correlation
    • Humans
    • Role
    • Serum
    • Tissue
  • peptide hormone
    • Secreted
    • Role
    • Protein
    • Hormone
    • Peptide
    • Retn
    • Gene
    • Tissue
    • Xcp1
    • Inflammation
    • Humans
    • Resistin
  • adipose tissue
    • Tissue
    • Protein
    • Retn
    • Secreted
    • Cells
    • Gene
    • Hormone
    • Molecular
    • Mouse
    • Xcp1
    • Activity
    • Adsf
  • gene
    • Location
    • Retn
    • Chromosome
    • Bp
    • Chr
    • Human
    • Mouse
    • Protein
    • Xcp1
    • Function
    • Band
    • Tissue
  • adipose-derived hormone
    • Role
    • Protein
    • Peptide
    • Retn
    • Secreted
    • Gene
    • Tissue
    • Inflammation
    • Resistin
    • Molecular
    • Mouse
    • Xcp1
  • function
    • Location
    • Retn
    • Chromosome
    • Gene
    • Bp
    • Chr
    • Human
    • Inflammation
    • Molecular
    • Mouse
    • Protein
    • Xcp1
  • insulin resistance
    • Resistance
    • May
    • Obesity
    • Levels
    • Retn
    • Resistin
    • Correlation
    • Location
    • T2dm
    • Inflammation
    • Mouse
    • Xcp1

Connections between topic areas Semantic bridges

For Resistin, one of the stronger structural bridges in this analysis connects Resistin with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
ResistinClinical significance · splits 46 ⟂ 18
ResistinOverview · splits 48 ⟂ 16
ResistinDiscovery and structure · splits 49 ⟂ 15
ResistinFunction · splits 50 ⟂ 14

Map overview Semantic statistics

Resistin

Nodes64
Edges63
Triples146
Avg. degree1.97
Density0.03125
Components1

Source & methodology

TTTA analyzes the structure around Resistin to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Clinical significance, Discovery and structure & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Resistin · EN edition · Analysis: TopicsToTalkAbout

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