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E3 ubiquitin-protein ligase RAD18 is an enzyme that in humans is encoded by the RAD18 gene. A knockout in a human colorectal cancer cell line, HCT116, has also been created.
The analysis highlights Function, Interactions and Overview as prominent areas in the source structure around RAD18.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around RAD18 shows recurring relationship patterns in the source. For example, RAD18 → cellular response to DNA damage stimulus, centrosome, cytoplasm, cytoskeleton, damaged DNA binding, DNA binding, DNA repair, identical protein binding, metal ion binding, microtubule organizing center, negative regulation of cell death, nuclear body, nuclear inclusion body, nucleoplasm, nucleus, polyubiquitin modification-dependent protein binding, positive regulation of chromosome segregation, postreplication repair, protein autoubiquitination, protein binding Another extracted example is RAD18 → Achilles tendon, bone marrow cell, epiblast, epithelium of colon, ganglionic eminence, genital tubercle, gonad, inner renal medulla, islet of Langerhans, jejunal mucosa, lumbar spinal ganglion, primary oocyte, secondary oocyte, spermatid, spermatocyte, stromal cell of endometrium, tail of embryo, testicle, ventricular zone, zygote. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
human bp gene dna chr band protein e3 ligase chromosome repair enzyme location ubiquitin activity mouse replication cell function encoded
TTTA extracted 115 structured relationships around RAD18. Examples in this analysis include RAD18 → 2.3.2.27 → ↗ and RAD18 → Aliases → RAD18, RNF73, E3 ubiquitin protein ligase, RAD18 E3 ubiquitin protein ligase. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| RAD18 | 2.3.2.27 | ↗ | 1.00 | infobox |
| RAD18 | Aliases | RAD18, RNF73, E3 ubiquitin protein ligase, RAD18 E3 ubiquitin protein ligase | 1.00 | infobox |
| RAD18 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2MRE, 2MRF, 2Y43, 2YBF | 1.00 | infobox |
| RAD18 | Band | 3p25.3 | 1.00 | infobox |
| RAD18 | Band | 6|6 E3 | 1.00 | infobox |
| RAD18 | Bgee | testicle | 1.00 | infobox |
| RAD18 | Bgee | Achilles tendon | 1.00 | infobox |
| RAD18 | Bgee | ventricular zone | 1.00 | infobox |
| RAD18 | Bgee | gonad | 1.00 | infobox |
| RAD18 | Bgee | ganglionic eminence | 1.00 | infobox |
| RAD18 | Bgee | jejunal mucosa | 1.00 | infobox |
| RAD18 | Bgee | stromal cell of endometrium | 1.00 | infobox |
| RAD18 | Bgee | epithelium of colon | 1.00 | infobox |
| RAD18 | Bgee | islet of Langerhans | 1.00 | infobox |
| RAD18 | Bgee | bone marrow cell | 1.00 | infobox |
| RAD18 | Bgee | tail of embryo | 1.00 | infobox |
| RAD18 | Bgee | zygote | 1.00 | infobox |
| RAD18 | Bgee | spermatocyte | 1.00 | infobox |
| RAD18 | Bgee | genital tubercle | 1.00 | infobox |
| RAD18 | Bgee | spermatid | 1.00 | infobox |
| RAD18 | Bgee | secondary oocyte | 1.00 | infobox |
| RAD18 | Bgee | primary oocyte | 1.00 | infobox |
| RAD18 | Bgee | epiblast | 1.00 | infobox |
| RAD18 | Bgee | lumbar spinal ganglion | 1.00 | infobox |
| RAD18 | Bgee | inner renal medulla | 1.00 | infobox |
| RAD18 | BioGPS | n/a | 1.00 | infobox |
| RAD18 | Chr. | Chromosome 3 (human) | 1.00 | infobox |
| RAD18 | Chr. | Chromosome 6 (mouse) | 1.00 | infobox |
| RAD18 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| RAD18 | End | 8,963,773 bp | 1.00 | infobox |
The concept neighborhoods around RAD18 bring nearby vocabulary together. In this analysis, examples include Dna, Repair and Ubiquitin. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For RAD18, one of the stronger structural bridges in this analysis connects RAD18 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around RAD18 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Interactions & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — RAD18 · EN edition · Analysis: TopicsToTalkAbout