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RAD18

E3 ubiquitin-protein ligase RAD18 is an enzyme that in humans is encoded by the RAD18 gene. A knockout in a human colorectal cancer cell line, HCT116, has also been created.

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2.3.2.27
Aliases
RAD18, RNF73, E3 ubiquitin protein ligase, RAD18 E3 ubiquitin protein ligase
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2MRE, 2MRF, 2Y43, 2YBF
Band
3p25.3 · 6|6 E3
Bgee
testicle · Achilles tendon · ventricular zone · gonad · ganglionic eminence
BioGPS
n/a

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Map overview Semantic statistics

RAD18

Nodes19
Edges18
Triples115
Avg. degree1.89
Density0.105263
Components1

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RAD18

Top relations

Gene ontology · 33
RAD18 → cellular response to DNA damage stimulus, centrosome, cytoplasm, cytoskeleton, damaged DNA binding, DNA binding, DNA repair, identical protein binding, metal ion binding, microtubule organizing center, negative regulation of cell death, nuclear body, nuclear inclusion body, nucleoplasm, nucleus, polyubiquitin modification-dependent protein binding, positive regulation of chromosome segregation, postreplication repair, protein autoubiquitination, protein binding
Bgee · 20
RAD18 → Achilles tendon, bone marrow cell, epiblast, epithelium of colon, ganglionic eminence, genital tubercle, gonad, inner renal medulla, islet of Langerhans, jejunal mucosa, lumbar spinal ganglion, primary oocyte, secondary oocyte, spermatid, spermatocyte, stromal cell of endometrium, tail of embryo, testicle, ventricular zone, zygote
RNA expression pattern · 20
RAD18 → Achilles tendon, bone marrow cell, epiblast, epithelium of colon, ganglionic eminence, genital tubercle, gonad, inner renal medulla, islet of Langerhans, jejunal mucosa, lumbar spinal ganglion, primary oocyte, secondary oocyte, spermatid, spermatocyte, stromal cell of endometrium, tail of embryo, testicle, ventricular zone, zygote
related to Function · 12
RAD18 → DNA, E3, Mutation, One, Rad6, Similar, SMC5, SMC5/6, SMC6, The, UV-damaged DNA, Yeast Rad18
related to Interactions · 3
RAD18 → HLTF, UBE2A, UBE2B
Band · 2
RAD18 → 3p25.3, 6|6 E3
Chr. · 2
RAD18 → Chromosome 3 (human), Chromosome 6 (mouse)
End · 2
RAD18 → 112,673,647 bp, 8,963,773 bp
is a · 2
RAD18 → E3 ubiquitin ligase that enables movement of ubiquitin from a ubiquitin carrier to another protein, enzyme that in humans is encoded by the RAD18 gene
2.3.2.27 · 1
RAD18 → ↗

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Important terminology

human bp gene dna chr band protein e3 ligase chromosome repair enzyme location ubiquitin activity mouse replication cell function encoded

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
RAD182.3.2.271.00infobox
RAD18AliasesRAD18, RNF73, E3 ubiquitin protein ligase, RAD18 E3 ubiquitin protein ligase1.00infobox
RAD18Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2MRE, 2MRF, 2Y43, 2YBF1.00infobox
RAD18Band3p25.31.00infobox
RAD18Band6|6 E31.00infobox
RAD18Bgeetesticle1.00infobox
RAD18BgeeAchilles tendon1.00infobox
RAD18Bgeeventricular zone1.00infobox
RAD18Bgeegonad1.00infobox
RAD18Bgeeganglionic eminence1.00infobox
RAD18Bgeejejunal mucosa1.00infobox
RAD18Bgeestromal cell of endometrium1.00infobox
RAD18Bgeeepithelium of colon1.00infobox
RAD18Bgeeislet of Langerhans1.00infobox
RAD18Bgeebone marrow cell1.00infobox
RAD18Bgeetail of embryo1.00infobox
RAD18Bgeezygote1.00infobox
RAD18Bgeespermatocyte1.00infobox
RAD18Bgeegenital tubercle1.00infobox
RAD18Bgeespermatid1.00infobox
RAD18Bgeesecondary oocyte1.00infobox
RAD18Bgeeprimary oocyte1.00infobox
RAD18Bgeeepiblast1.00infobox
RAD18Bgeelumbar spinal ganglion1.00infobox
RAD18Bgeeinner renal medulla1.00infobox
RAD18BioGPSn/a1.00infobox
RAD18Chr.Chromosome 3 (human)1.00infobox
RAD18Chr.Chromosome 6 (mouse)1.00infobox
RAD18DatabasesNCBI: entry; OMA: entry1.00infobox
RAD18End8,963,773 bp1.00infobox

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