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Pyocyanin

Pyocyanin (PCN−) is one of the many toxic compounds produced and secreted by the Gram negative bacterium Pseudomonas aeruginosa. Pyocyanin is a blue secondary metabolite, turning red below pH 4.9, with the ability to oxidise and reduce other molecules and therefore kill microbes competing against P. aeruginosa as well as mammalian cells of the lungs…

Redox warfare, Targets & Cystic fibrosis

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Redox warfare

CatalaseGlutathioneNADPHNADPH oxidaseCytokines
9 related topics

Targets

Electron transport chainV-ATPaseApoptosisNecrosisLymphocytes
8 related topics

Cystic fibrosis

NeutrophilB-lymphocytesIL-8CCL5ATP
7 related topics

Defence against pyocyanin

Caenorhabditis elegansABC transporters
2 related topics

Topics to explore

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Overview

Biosynthesis

Redox warfare

Targets

Cystic fibrosis

Defence against pyocyanin

Advanced semantic analysis

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Map overview Semantic statistics

Pyocyanin

Nodes39
Edges38
Triples83
Avg. degree1.95
Density0.051282
Components1

How this topic connects Entity context

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Pyocyanin

Top relations

related to Biosynthesis · 32
Pyocyanin → ADIC, AOCHC, Biosynthesis, C1, C3, C4, Chorismic Acid, Conversion, DHHA, DHPCA, Following, From, HHPDC, In, MvfR, N5, PCA, PhzB, PhzD, PhzE
related to Cystic fibrosis · 16
Pyocyanin → Additionally, ATP, B-lymphocytes, Both, CCL5, CFTR, Firstly, IL-8, In, Many, NAD, PKA, Protein, Secondly, The, This
related to Targets · 13
Pyocyanin → Additional, An, ATP, ATPase, DNA, Mitochondrial, Mutations, Pathways, The, Therefore, This, V-ATPase, Vacuolar- ATPase
related to Redox warfare · 11
Pyocyanin → Firstly, Glutathione, IFN-γ, IL-13, IL-4, In, NADP, NADPH, Secondly, This, When
is a · 2
Pyocyanin → blue secondary metabolite, zwitterion at blood pH
related to Defence against pyocyanin · 2
Pyocyanin → ABC, Caenorhabditis

Important terminology Word statistics

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Important terminology

cystic fibrosis aeruginosa acid atp form two lung also superoxide pca enzyme catalyzes produced well cell oxygen synthesis hydrogen impaired

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Pyocyaninis ablue secondary metabolite0.90text
Pyocyaninis azwitterion at blood pH0.90text
calcium homeostatic controlinstance ofVacuolar- ATPase in yeast cells is a particularly potent target as it is the main non-mitochondrial producer of ATP but also has numerous other functions0.80text
the facilitation of receptor-mediated endocytosisinstance ofVacuolar- ATPase in yeast cells is a particularly potent target as it is the main non-mitochondrial producer of ATP but also has numerous other functions0.80text
the degradation of proteinsinstance ofVacuolar- ATPase in yeast cells is a particularly potent target as it is the main non-mitochondrial producer of ATP but also has numerous other functions0.80text
DNA recombinationinstance ofwhich cause oxidative stress by directly damaging DNA or by targeting other constituents of the cell cycle0.80text
repair machineryinstance ofwhich cause oxidative stress by directly damaging DNA or by targeting other constituents of the cell cycle0.80text
ciliary beatinginstance ofPyocyanin in vitro has the ability to interfere with functions0.80text
therefore cause epithelial dysfunction as the ciliary are needed to sweep mucus up the throatinstance ofPyocyanin in vitro has the ability to interfere with functions0.80text
Pyocyaninrelated to BiosynthesisPCA0.60section
Pyocyaninrelated to BiosynthesisIn0.60section
Pyocyaninrelated to BiosynthesisPhzE0.60section

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