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PRRX1: Regions, Role in mesenchymal stem cell differentiation & Function

Paired related homeobox 1 is a protein that in humans is encoded by the PRRX1 gene.

Language: English [EN]
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PRRX1 topic overview

The analysis highlights Regions, Role in mesenchymal stem cell differentiation and Function as prominent areas in the source structure around PRRX1.

Related topics
15
Source areas
3
Connected nodes
18
Extracted relationships
99
Concept neighborhoods
10
Bridge connections
18

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Role in mesenchymal stem cell differentiation · 8 topics
Function · 5 topics
Overview · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
PRRX1, AGOTC, PHOX1, PMX1, PRX-1, PRX1, paired related homeobox 1
Band
1q24.2 · 1 H2.1|1 70.53 cM
Bgee
Achilles tendon · urethra · tendon of biceps brachii · saphenous vein · parietal pleura
BioGPS
More reference expression data
Chr.
Chromosome 1 (human) · Chromosome 1 (mouse)
Databases
NCBI: entry; OMA: entry

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Role in mesenchymal stem cell differentiation

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How PRRX1 connects Entity context

The extracted context around PRRX1 shows recurring relationship patterns in the source. For example, PRRX1 → artery morphogenesis, cartilage development, cytosol, DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, embryonic cranial skeleton morphogenesis, embryonic limb morphogenesis, embryonic skeletal system morphogenesis, HMG box domain binding, inner ear morphogenesis, middle ear morphogenesis, multicellular organism development, negative regulation of transcription by RNA polymerase II, neuron fate determination, neuronal stem cell population maintenance, nucleoplasm, nucleus, positive regulation of mesenchymal cell proliferation, positive regulation of smoothened signaling pathway Another extracted example is PRRX1 → Achilles tendon, ankle, body of femur, calvaria, dermis, foot, genital tubercle, mandibular prominence, maxillary prominence, parietal pleura, pericardium, saphenous vein, seminal vesicula, skin of external ear, skin of hip, stroma of bone marrow, synovial joint, tendon of biceps brachii, urethra, vena cava. Use these groups to spot repeated connection types before inspecting the individual relationships.

PRRX1

Top relations

Gene ontology · 28
PRRX1 → artery morphogenesis, cartilage development, cytosol, DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, embryonic cranial skeleton morphogenesis, embryonic limb morphogenesis, embryonic skeletal system morphogenesis, HMG box domain binding, inner ear morphogenesis, middle ear morphogenesis, multicellular organism development, negative regulation of transcription by RNA polymerase II, neuron fate determination, neuronal stem cell population maintenance, nucleoplasm, nucleus, positive regulation of mesenchymal cell proliferation, positive regulation of smoothened signaling pathway
Bgee · 20
PRRX1 → Achilles tendon, ankle, body of femur, calvaria, dermis, foot, genital tubercle, mandibular prominence, maxillary prominence, parietal pleura, pericardium, saphenous vein, seminal vesicula, skin of external ear, skin of hip, stroma of bone marrow, synovial joint, tendon of biceps brachii, urethra, vena cava
RNA expression pattern · 20
PRRX1 → Achilles tendon, ankle, body of femur, calvaria, dermis, foot, genital tubercle, mandibular prominence, maxillary prominence, parietal pleura, pericardium, saphenous vein, seminal vesicula, skin of external ear, skin of hip, stroma of bone marrow, synovial joint, tendon of biceps brachii, urethra, vena cava
related to External links · 6
PRRX1 → Medicine, Medicine Medical Subject Headings, MeSH, National Library, This, United States National Library
related to Role in mesenchymal stem cell differentiation · 5
PRRX1 → For, Mice, Prrx2, Several, TGF-beta
Band · 2
PRRX1 → 1 H2.1|1 70.53 cM, 1q24.2
Chr. · 2
PRRX1 → Chromosome 1 (human), Chromosome 1 (mouse)
End · 2
PRRX1 → 163,141,279 bp, 170,739,421 bp
Aliases · 1
PRRX1 → PRRX1, AGOTC, PHOX1, PMX1, PRX-1, PRX1, paired related homeobox 1
BioGPS · 1
PRRX1 → More reference expression data

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

bp human protein gene chr band mesenchymal chromosome differentiation homeobox external paired location cell mouse expression related function stem encoded

PRRX1 relationships Subject–Predicate–Object triples

TTTA extracted 99 structured relationships around PRRX1. Examples in this analysis include PRRX1 → Aliases → PRRX1, AGOTC, PHOX1, PMX1, PRX-1, PRX1, paired related homeobox 1 and PRRX1 → Band → 1q24.2. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
PRRX1AliasesPRRX1, AGOTC, PHOX1, PMX1, PRX-1, PRX1, paired related homeobox 11.00infobox
PRRX1Band1q24.21.00infobox
PRRX1Band1 H2.1|1 70.53 cM1.00infobox
PRRX1BgeeAchilles tendon1.00infobox
PRRX1Bgeeurethra1.00infobox
PRRX1Bgeetendon of biceps brachii1.00infobox
PRRX1Bgeesaphenous vein1.00infobox
PRRX1Bgeeparietal pleura1.00infobox
PRRX1Bgeesynovial joint1.00infobox
PRRX1Bgeevena cava1.00infobox
PRRX1Bgeepericardium1.00infobox
PRRX1Bgeeskin of hip1.00infobox
PRRX1Bgeeseminal vesicula1.00infobox
PRRX1Bgeecalvaria1.00infobox
PRRX1Bgeemaxillary prominence1.00infobox
PRRX1Bgeedermis1.00infobox
PRRX1Bgeegenital tubercle1.00infobox
PRRX1Bgeefoot1.00infobox
PRRX1Bgeeankle1.00infobox
PRRX1Bgeemandibular prominence1.00infobox
PRRX1Bgeestroma of bone marrow1.00infobox
PRRX1Bgeebody of femur1.00infobox
PRRX1Bgeeskin of external ear1.00infobox
PRRX1BioGPSMore reference expression data1.00infobox
PRRX1Chr.Chromosome 1 (human)1.00infobox
PRRX1Chr.Chromosome 1 (mouse)1.00infobox
PRRX1DatabasesNCBI: entry; OMA: entry1.00infobox
PRRX1End170,739,421 bp1.00infobox
PRRX1End163,141,279 bp1.00infobox
PRRX1EnsemblENSG000001161321.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around PRRX1 bring nearby vocabulary together. In this analysis, examples include Mesenchymal, Differentiation and Cell. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • PRRX1
    • Mesenchymal
    • Differentiation
    • Cell
    • Human
    • Expressed
    • External
    • Function
    • Prrx2
    • Region
    • Related
    • Stem
    • Expression
  • prrx1
    • Mesenchymal
    • Differentiation
    • Cell
    • Human
    • Expressed
    • External
    • Function
    • Prrx2
    • Region
    • Related
    • Stem
    • Expression
  • protein
    • Activity
    • Coactivator
    • Dna-binding
    • Transcription
    • Prrx1
    • Human
    • Nucleus
    • Domain
    • End
    • Expressed
    • External
    • Function
  • gene
    • Homeobox
    • Location
    • Paired
    • Chromosome
    • Bp
    • Chr
    • End
    • External
    • Function
    • H2
    • Human
    • Mouse
  • homeobox
    • Paired
    • Gene
    • Encoded
    • External
    • Function
    • Related
    • Stem
    • Cell
    • Location
    • Chromosome
    • Prrx1
    • Bp
  • transcription coactivator
    • Activity
    • Coactivator
    • Dna-binding
    • Transcription
    • Nucleus
    • Protein
    • Domain
    • Encoded
    • End
    • Expressed
    • External
    • Function
  • function
    • External
    • Stem
    • Cell
    • Homeobox
    • Location
    • Paired
    • Chromosome
    • Gene
    • Nucleus
    • Bp
    • Chr
    • Human
  • role in mesenchymal stem cell differentiation
    • External
    • Function
    • Region
    • Stem
    • Prrx1
    • Mesenchymal
    • Homeobox
    • Location
    • Paired
    • Chromosome
    • Expressed
    • Gene

Connections between topic areas Semantic bridges

For PRRX1, one of the stronger structural bridges in this analysis connects PRRX1 with Role in mesenchymal stem cell differentiation. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
PRRX1Role in mesenchymal stem cell differentiation · splits 10 ⟂ 9
PRRX1Function · splits 13 ⟂ 6
PRRX1Overview · splits 16 ⟂ 3

Map overview Semantic statistics

PRRX1

Nodes19
Edges18
Triples99
Avg. degree1.89
Density0.105263
Components1

Source & methodology

TTTA analyzes the structure around PRRX1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Regions, Role in mesenchymal stem cell differentiation & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — PRRX1 · EN edition · Analysis: TopicsToTalkAbout

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