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PABPC1

Polyadenylate-binding protein 1 is a protein that in humans is encoded by the PABPC1 gene. The protein PABP1 binds mRNA and facilitates a variety of functions such as transport into and out of the nucleus, degradation, translation, and stability. There are two separate PABP1 proteins, one which is located in the nucleus (PABPN1) and the other which is…

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Interactions

InteractANAPC5CNOT7EIF4G3EIF4G1
8 related topics

Function

Poly(A)-binding proteinsNonsense-mediated decay
2 related topics

Overview

ProteinGene
2 related topics

Key facts & relationships

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Aliases
PABPC1, PAB1, PABP, PABP1, PABPC2, PABPL1, poly(A) binding protein cytoplasmic 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1CVJ, 1G9L, 1JGN, 1JH4, 2K8G, 2RQG, 2RQH, 2X04, 3KTP, 3KTR, 3KUI, 3KUJ, 3KUR, 3KUS, 3KUT, 3PKN, 3PTH, 4F02,…
Band
8q22.3 · 15|15 B3.1
Bgee
parotid gland · pylorus · gonad · amniotic fluid · vulva
BioGPS
n/a
Chr.
Chromosome 8 (human) · Chromosome 15 (mouse)

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Overview

Function

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Map overview Semantic statistics

PABPC1

Nodes16
Edges15
Triples123
Avg. degree1.88
Density0.125
Components1

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PABPC1

Top relations

Gene ontology · 39
PABPC1 → catalytic step 2 spliceosome, cytoplasm, cytoplasmic ribonucleoprotein granule, cytoplasmic stress granule, cytosol, dendrite, extracellular exosome, focal adhesion, gene silencing, membrane, messenger ribonucleoprotein complex, mRNA 3'-UTR binding, mRNA binding, mRNA polyadenylation, mRNA processing, mRNA splicing, via spliceosome, mRNA stabilization, negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, nuclear-transcribed mRNA poly(A) tail shortening
Bgee · 20
PABPC1 → amniotic fluid, embryo, genital tubercle, gonad, lip, monocyte, morula, neural layer of retina, nipple, oral cavity, parotid gland, pylorus, spermatid, spermatocyte, tail of embryo, tonsil, trabecular bone, ventricular zone, vulva, yolk sac
RNA expression pattern · 20
PABPC1 → amniotic fluid, embryo, genital tubercle, gonad, lip, monocyte, morula, neural layer of retina, nipple, oral cavity, parotid gland, pylorus, spermatid, spermatocyte, tail of embryo, tonsil, trabecular bone, ventricular zone, vulva, yolk sac
related to Function · 7
PABPC1 → In, NMD, PAB, PABP, PABPs, The, This
related to Interactions · 6
PABPC1 → ANAPC5, CNOT7, EIF4G1, EIF4G3, GSPT2, PAIP1
Band · 2
PABPC1 → 15|15 B3.1, 8q22.3
Chr. · 2
PABPC1 → Chromosome 15 (mouse), Chromosome 8 (human)
End · 2
PABPC1 → 100,722,809 bp, 36,609,912 bp
Aliases · 1
PABPC1 → PABPC1, PAB1, PABP, PABP1, PABPC2, PABPL1, poly(A) binding protein cytoplasmic 1
Available structures · 1
PABPC1 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1CVJ, 1G9L, 1JGN, 1JH4, 2K8G, 2RQG, 2RQH, 2X04, 3KTP, 3KTR, 3KUI, 3KUJ, 3KUR, 3KUS, 3KUT, 3PKN, 3PTH, 4F02,…

Important terminology Word statistics

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Important terminology

protein mrna pabp1 bp poly gene nucleus chr human band location chromosome function cytoplasm tail translation stability binds degradation binding

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
PABPC1AliasesPABPC1, PAB1, PABP, PABP1, PABPC2, PABPL1, poly(A) binding protein cytoplasmic 11.00infobox
PABPC1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1CVJ, 1G9L, 1JGN, 1JH4, 2K8G, 2RQG, 2RQH, 2X04, 3KTP, 3KTR, 3KUI, 3KUJ, 3KUR, 3KUS, 3KUT, 3PKN, 3PTH, 4F02,…1.00infobox
PABPC1Band8q22.31.00infobox
PABPC1Band15|15 B3.11.00infobox
PABPC1Bgeeparotid gland1.00infobox
PABPC1Bgeepylorus1.00infobox
PABPC1Bgeegonad1.00infobox
PABPC1Bgeeamniotic fluid1.00infobox
PABPC1Bgeevulva1.00infobox
PABPC1Bgeetonsil1.00infobox
PABPC1Bgeenipple1.00infobox
PABPC1Bgeetrabecular bone1.00infobox
PABPC1Bgeemonocyte1.00infobox
PABPC1Bgeeoral cavity1.00infobox
PABPC1Bgeetail of embryo1.00infobox
PABPC1Bgeegenital tubercle1.00infobox
PABPC1Bgeeventricular zone1.00infobox
PABPC1Bgeeyolk sac1.00infobox
PABPC1Bgeespermatocyte1.00infobox
PABPC1Bgeemorula1.00infobox
PABPC1Bgeeneural layer of retina1.00infobox
PABPC1Bgeespermatid1.00infobox
PABPC1Bgeeembryo1.00infobox
PABPC1Bgeelip1.00infobox
PABPC1BioGPSn/a1.00infobox
PABPC1Chr.Chromosome 8 (human)1.00infobox
PABPC1Chr.Chromosome 15 (mouse)1.00infobox
PABPC1DatabasesNCBI: entry; OMA: entry1.00infobox
PABPC1End100,722,809 bp1.00infobox
PABPC1End36,609,912 bp1.00infobox

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