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Platelet factor 4: Clinical significance, Function & Genomics

Platelet factor 4 (PF4) is a small cytokine belonging to the CXC chemokine family that is also known as chemokine (C-X-C motif) ligand 4 (CXCL4) . This chemokine is released from alpha-granules of activated platelets during platelet aggregation, and promotes blood coagulation by moderating the effects of heparin-like molecules. Due to these roles, it is…

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Platelet factor 4 topic overview

The analysis highlights Clinical significance, Function and Genomics as prominent areas in the source structure around Platelet factor 4.

Related topics
27
Source areas
4
Connected nodes
31
Extracted relationships
107
Concept neighborhoods
15
Bridge connections
31

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Clinical significance · 10 topics
Overview · 9 topics
Function · 6 topics
Genomics · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
PF4, CXCL4, PF-4, SCYB4, platelet factor 4
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1RHP, 1DN3, 1F9Q, 1F9R, 1F9S, 1PFM, 1PFN, 4R9W, 4R9Y, 4RAU
Band
4q13.3 · 5|5 E1
Bgee
monocyte · trabecular bone · granulocyte · blood · gonad
BioGPS
More reference expression data
Chr.
Chromosome 4 (human) · Chromosome 5 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Genomics

Function

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Platelet factor 4 connects Entity context

The extracted context around Platelet factor 4 shows recurring relationship patterns in the source. For example, Platelet factor 4 → adenylate cyclase-activating G protein-coupled receptor signaling pathway, antimicrobial humoral immune response mediated by antimicrobial peptide, cellular response to lipopolysaccharide, chemokine activity, chemokine-mediated signaling pathway, chemotaxis, collagen-containing extracellular matrix, CXCR3 chemokine receptor binding, cytokine activity, cytokine-mediated signaling pathway, cytoplasm, defense response, extracellular region, extracellular space, G protein-coupled receptor signaling pathway, heparin binding, immune response, inflammatory response, leukocyte chemotaxis, negative regulation of angiogenesis Another extracted example is Platelet factor 4 → ankle, blood, bone marrow, bone marrow cell, carotid body, dermis, fetal liver hematopoietic progenitor cell, gonad, granulocyte, monocyte, periodontal fiber, sciatic nerve, spleen, stroma of bone marrow, testicle, tibiofemoral joint, trabecular bone, vestibular sensory epithelium. Use these groups to spot repeated connection types before inspecting the individual relationships.

Platelet factor 4

Top relations

Gene ontology · 40
Platelet factor 4 → adenylate cyclase-activating G protein-coupled receptor signaling pathway, antimicrobial humoral immune response mediated by antimicrobial peptide, cellular response to lipopolysaccharide, chemokine activity, chemokine-mediated signaling pathway, chemotaxis, collagen-containing extracellular matrix, CXCR3 chemokine receptor binding, cytokine activity, cytokine-mediated signaling pathway, cytoplasm, defense response, extracellular region, extracellular space, G protein-coupled receptor signaling pathway, heparin binding, immune response, inflammatory response, leukocyte chemotaxis, negative regulation of angiogenesis
Bgee · 18
Platelet factor 4 → ankle, blood, bone marrow, bone marrow cell, carotid body, dermis, fetal liver hematopoietic progenitor cell, gonad, granulocyte, monocyte, periodontal fiber, sciatic nerve, spleen, stroma of bone marrow, testicle, tibiofemoral joint, trabecular bone, vestibular sensory epithelium
RNA expression pattern · 18
Platelet factor 4 → ankle, blood, bone marrow, bone marrow cell, carotid body, dermis, fetal liver hematopoietic progenitor cell, gonad, granulocyte, monocyte, periodontal fiber, sciatic nerve, spleen, stroma of bone marrow, testicle, tibiofemoral joint, trabecular bone, vestibular sensory epithelium
related to Antibodies · 7
Platelet factor 4 → At, HIT, Monoclonal, PF4, Platelet, The, There
Band · 2
Platelet factor 4 → 4q13.3, 5|5 E1
Chr. · 2
Platelet factor 4 → Chromosome 4 (human), Chromosome 5 (mouse)
End · 2
Platelet factor 4 → 73,982,027 bp, 90,921,242 bp
Aliases · 1
Platelet factor 4 → PF4, CXCL4, PF-4, SCYB4, platelet factor 4
Available structures · 1
Platelet factor 4 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1RHP, 1DN3, 1F9Q, 1F9R, 1F9S, 1PFM, 1PFN, 4R9W, 4R9Y, 4RAU
BioGPS · 1
Platelet factor 4 → More reference expression data

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

pf4 platelet human bp factor chr band chemokine chromosome gene also heparin blood location expression thrombocytopenia role cytokine antibodies mouse

Platelet factor 4 relationships Subject–Predicate–Object triples

TTTA extracted 107 structured relationships around Platelet factor 4. Examples in this analysis include Platelet factor 4 → Aliases → PF4, CXCL4, PF-4, SCYB4, platelet factor 4 and Platelet factor 4 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1RHP, 1DN3, 1F9Q, 1F9R, 1F9S, 1PFM, 1PFN, 4R9W, 4R9Y, 4RAU. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Platelet factor 4AliasesPF4, CXCL4, PF-4, SCYB4, platelet factor 41.00infobox
Platelet factor 4Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1RHP, 1DN3, 1F9Q, 1F9R, 1F9S, 1PFM, 1PFN, 4R9W, 4R9Y, 4RAU1.00infobox
Platelet factor 4Band4q13.31.00infobox
Platelet factor 4Band5|5 E11.00infobox
Platelet factor 4Bgeemonocyte1.00infobox
Platelet factor 4Bgeetrabecular bone1.00infobox
Platelet factor 4Bgeegranulocyte1.00infobox
Platelet factor 4Bgeeblood1.00infobox
Platelet factor 4Bgeegonad1.00infobox
Platelet factor 4Bgeebone marrow1.00infobox
Platelet factor 4Bgeetesticle1.00infobox
Platelet factor 4Bgeebone marrow cell1.00infobox
Platelet factor 4Bgeeperiodontal fiber1.00infobox
Platelet factor 4Bgeespleen1.00infobox
Platelet factor 4Bgeetibiofemoral joint1.00infobox
Platelet factor 4Bgeesciatic nerve1.00infobox
Platelet factor 4Bgeestroma of bone marrow1.00infobox
Platelet factor 4Bgeefetal liver hematopoietic progenitor cell1.00infobox
Platelet factor 4Bgeedermis1.00infobox
Platelet factor 4Bgeeankle1.00infobox
Platelet factor 4Bgeevestibular sensory epithelium1.00infobox
Platelet factor 4Bgeecarotid body1.00infobox
Platelet factor 4BioGPSMore reference expression data1.00infobox
Platelet factor 4Chr.Chromosome 4 (human)1.00infobox
Platelet factor 4Chr.Chromosome 5 (mouse)1.00infobox
Platelet factor 4DatabasesNCBI: entry; OMA: entry1.00infobox
Platelet factor 4End73,982,027 bp1.00infobox
Platelet factor 4End90,921,242 bp1.00infobox
Platelet factor 4EnsemblENSG000001637371.00infobox
Platelet factor 4Entrez51961.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Platelet factor 4 bring nearby vocabulary together. In this analysis, examples include Platelet, Cxcl4 and Cytokine. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Platelet factor 4
    • Platelet
    • Cxcl4
    • Cytokine
    • Ligand
    • Human
    • Also
    • Chemokine
    • Function
    • Pf4
    • Platelets
    • Released
    • Search
  • platelet factor 4
    • Platelet
    • Human
    • Cxcl4
    • Cytokine
    • Function
    • Ligand
    • Search
    • Antibodies
    • Expression
    • Gene
    • Location
    • Also
  • chemokine
    • Cytokine
    • Known
    • Ligand
    • Blood
    • Platelet
    • Pf4
    • Factor
    • Activated
    • Alpha-granules
    • Coagulation
    • Cxcl4
    • Function
  • cytokine
    • Ligand
    • Chemokine
    • Cxcl4
    • Factor
    • Function
    • Known
    • Mouse
    • Search
    • Blood
    • Expression
    • Gene
    • Location
  • chromosome 4
    • Bp
    • Human
    • Gene
    • Location
    • Band
    • Function
    • Mouse
    • Search
    • Expression
    • External
    • Factor
    • Cxcl4
  • function
    • Search
    • Gene
    • Location
    • Chromosome
    • Bp
    • Chr
    • Human
    • Ligand
    • Mouse
    • Platelet
    • Pf4
    • Band
  • heparin
    • Pf4
    • Found
    • Ligand
    • Mouse
    • Platelet
    • Platelets
    • Released
    • Search
    • Location
    • Thrombosis
    • Thrombocytopenia
    • Human
  • alpha-granules
    • Activated
    • Platelets
    • Released
    • Coagulation
    • Heparin-like
    • Molecules
    • Blood
    • Platelet
    • Chemokine
    • Heparin

Connections between topic areas Semantic bridges

For Platelet factor 4, one of the stronger structural bridges in this analysis connects Platelet factor 4 with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Platelet factor 4Clinical significance · splits 21 ⟂ 11
Platelet factor 4Overview · splits 22 ⟂ 10
Platelet factor 4Function · splits 25 ⟂ 7
Platelet factor 4Genomics · splits 29 ⟂ 3

Map overview Semantic statistics

Platelet factor 4

Nodes32
Edges31
Triples107
Avg. degree1.94
Density0.0625
Components1

Source & methodology

TTTA analyzes the structure around Platelet factor 4 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Clinical significance, Function & Genomics, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Platelet factor 4 · EN edition · Analysis: TopicsToTalkAbout

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