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PCSK6

Proprotein convertase subtilisin/kexin type 6 is an protease that in humans is encoded by the PCSK6 gene which is located in chromosome 15. Pcsk6 is a calcium-dependent serine endoprotease that catalyzes the post-translational modification of precursor proteins from its 'latent' form to the cleaved 'active' form. Active Pcsk6 has been reported to process…

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Function, Clinical significance & Overview

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Key facts & relationships

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Aliases
PCSK6, PACE4, SPC4, proprotein convertase subtilisin/kexin type 6
Band
15q26.3 · 7 C|7 35.36 cM
Bgee
C1 segment · liver · right lobe of liver · middle frontal gyrus · corpus callosum
BioGPS
More reference expression data
Chr.
Chromosome 15 (human) · Chromosome 7 (mouse)
Databases
NCBI: entry; OMA: entry

Topics to explore

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Overview

Function

Clinical significance

Advanced semantic analysis

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Map overview Semantic statistics

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PCSK6

Nodes24
Edges23
Triples111
Avg. degree1.92
Density0.083333
Components1

How this topic connects Entity context

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PCSK6

Top relations

Gene ontology · 30
PCSK6 → cell surface, collagen-containing extracellular matrix, cornification, determination of left/right symmetry, endomembrane system, endopeptidase activity, endoplasmic reticulum, extracellular matrix, extracellular region, extracellular space, glycoprotein metabolic process, Golgi lumen, heparin binding, hydrolase activity, membrane, nerve growth factor binding, nerve growth factor processing, nerve growth factor production, peptidase activity, peptide hormone processing
Bgee · 20
PCSK6 → ankle, body of femur, C1 segment, calvaria, cerebellar vermis, corpus callosum, Dermatocranium, esophagus, inferior ganglion of vagus nerve, inferior olivary nucleus, left lobe of liver, lip, liver, membranous bone, middle frontal gyrus, right lobe of liver, spleen, stria vascularis, subthalamic nucleus, synovial joint
RNA expression pattern · 20
PCSK6 → ankle, body of femur, C1 segment, calvaria, cerebellar vermis, corpus callosum, Dermatocranium, esophagus, inferior ganglion of vagus nerve, inferior olivary nucleus, left lobe of liver, lip, liver, membranous bone, middle frontal gyrus, right lobe of liver, spleen, stria vascularis, subthalamic nucleus, synovial joint
related to Cardiovascular disease · 8
PCSK6 → Asp282Asn, D282N, G/A, In, MMP14, Pcsk6 KO, PDGFB, When Pcsk6
related to During development · 8
PCSK6 → BMP, BMPs, Developmental Pcsk6, Elevated, Nodal, TGFβ, The, Throughout
Band · 2
PCSK6 → 15q26.3, 7 C|7 35.36 cM
Chr. · 2
PCSK6 → Chromosome 15 (human), Chromosome 7 (mouse)
End · 2
PCSK6 → 101,525,202 bp, 65,700,134 bp
Aliases · 1
PCSK6 → PCSK6, PACE4, SPC4, proprotein convertase subtilisin/kexin type 6
BioGPS · 1
PCSK6 → More reference expression data

Important terminology Word statistics

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Important terminology

gene bp chromosome 15 chr human band proprotein factor cardiovascular convertase process growth left location encoded precursor proteins corin subtilisin

Entity relationships Subject–Predicate–Object triples

Extracted RDF-like relationships with confidence and source. The table includes structured facts and lower-confidence contextual relations.
SubjectPredicateObjectConfidenceSrc
PCSK6AliasesPCSK6, PACE4, SPC4, proprotein convertase subtilisin/kexin type 61.00infobox
PCSK6Band15q26.31.00infobox
PCSK6Band7 C|7 35.36 cM1.00infobox
PCSK6BgeeC1 segment1.00infobox
PCSK6Bgeeliver1.00infobox
PCSK6Bgeeright lobe of liver1.00infobox
PCSK6Bgeemiddle frontal gyrus1.00infobox
PCSK6Bgeecorpus callosum1.00infobox
PCSK6Bgeespleen1.00infobox
PCSK6Bgeeinferior ganglion of vagus nerve1.00infobox
PCSK6Bgeeinferior olivary nucleus1.00infobox
PCSK6Bgeesynovial joint1.00infobox
PCSK6Bgeesubthalamic nucleus1.00infobox
PCSK6Bgeeankle1.00infobox
PCSK6BgeeDermatocranium1.00infobox
PCSK6Bgeecalvaria1.00infobox
PCSK6Bgeestria vascularis1.00infobox
PCSK6Bgeelip1.00infobox
PCSK6Bgeeesophagus1.00infobox
PCSK6Bgeeleft lobe of liver1.00infobox
PCSK6Bgeemembranous bone1.00infobox
PCSK6Bgeebody of femur1.00infobox
PCSK6Bgeecerebellar vermis1.00infobox
PCSK6BioGPSMore reference expression data1.00infobox
PCSK6Chr.Chromosome 15 (human)1.00infobox
PCSK6Chr.Chromosome 7 (mouse)1.00infobox
PCSK6DatabasesNCBI: entry; OMA: entry1.00infobox
PCSK6End101,525,202 bp1.00infobox
PCSK6End65,700,134 bp1.00infobox
PCSK6EnsemblENSG000001404791.00infobox

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