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PCSK6: Function, Clinical significance & Overview

Proprotein convertase subtilisin/kexin type 6 is an protease that in humans is encoded by the PCSK6 gene which is located in chromosome 15. Pcsk6 is a calcium-dependent serine endoprotease that catalyzes the post-translational modification of precursor proteins from its 'latent' form to the cleaved 'active' form. Active Pcsk6 has been reported to process…

Language: English [EN]
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PCSK6 topic overview

The analysis highlights Function, Clinical significance and Overview as prominent areas in the source structure around PCSK6.

Related topics
20
Source areas
3
Connected nodes
23
Extracted relationships
111
Concept neighborhoods
13
Bridge connections
23

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 12 topics
Clinical significance · 4 topics
Function · 4 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
PCSK6, PACE4, SPC4, proprotein convertase subtilisin/kexin type 6
Band
15q26.3 · 7 C|7 35.36 cM
Bgee
C1 segment · liver · right lobe of liver · middle frontal gyrus · corpus callosum
BioGPS
More reference expression data
Chr.
Chromosome 15 (human) · Chromosome 7 (mouse)
Databases
NCBI: entry; OMA: entry

Suggested research paths

A focused starting point derived from the topic graph, ranked independently of the source article order.

Start with these areas

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How PCSK6 connects Entity context

The extracted context around PCSK6 shows recurring relationship patterns in the source. For example, PCSK6 → cell surface, collagen-containing extracellular matrix, cornification, determination of left/right symmetry, endomembrane system, endopeptidase activity, endoplasmic reticulum, extracellular matrix, extracellular region, extracellular space, glycoprotein metabolic process, Golgi lumen, heparin binding, hydrolase activity, membrane, nerve growth factor binding, nerve growth factor processing, nerve growth factor production, peptidase activity, peptide hormone processing Another extracted example is PCSK6 → ankle, body of femur, C1 segment, calvaria, cerebellar vermis, corpus callosum, Dermatocranium, esophagus, inferior ganglion of vagus nerve, inferior olivary nucleus, left lobe of liver, lip, liver, membranous bone, middle frontal gyrus, right lobe of liver, spleen, stria vascularis, subthalamic nucleus, synovial joint. Use these groups to spot repeated connection types before inspecting the individual relationships.

PCSK6

Top relations

Gene ontology · 30
PCSK6 → cell surface, collagen-containing extracellular matrix, cornification, determination of left/right symmetry, endomembrane system, endopeptidase activity, endoplasmic reticulum, extracellular matrix, extracellular region, extracellular space, glycoprotein metabolic process, Golgi lumen, heparin binding, hydrolase activity, membrane, nerve growth factor binding, nerve growth factor processing, nerve growth factor production, peptidase activity, peptide hormone processing
Bgee · 20
PCSK6 → ankle, body of femur, C1 segment, calvaria, cerebellar vermis, corpus callosum, Dermatocranium, esophagus, inferior ganglion of vagus nerve, inferior olivary nucleus, left lobe of liver, lip, liver, membranous bone, middle frontal gyrus, right lobe of liver, spleen, stria vascularis, subthalamic nucleus, synovial joint
RNA expression pattern · 20
PCSK6 → ankle, body of femur, C1 segment, calvaria, cerebellar vermis, corpus callosum, Dermatocranium, esophagus, inferior ganglion of vagus nerve, inferior olivary nucleus, left lobe of liver, lip, liver, membranous bone, middle frontal gyrus, right lobe of liver, spleen, stria vascularis, subthalamic nucleus, synovial joint
related to Cardiovascular disease · 8
PCSK6 → Asp282Asn, D282N, G/A, In, MMP14, Pcsk6 KO, PDGFB, When Pcsk6
related to During development · 8
PCSK6 → BMP, BMPs, Developmental Pcsk6, Elevated, Nodal, TGFβ, The, Throughout
Band · 2
PCSK6 → 15q26.3, 7 C|7 35.36 cM
Chr. · 2
PCSK6 → Chromosome 15 (human), Chromosome 7 (mouse)
End · 2
PCSK6 → 101,525,202 bp, 65,700,134 bp
Aliases · 1
PCSK6 → PCSK6, PACE4, SPC4, proprotein convertase subtilisin/kexin type 6
BioGPS · 1
PCSK6 → More reference expression data

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene bp chromosome 15 chr human band proprotein factor cardiovascular convertase process growth left location encoded precursor proteins corin subtilisin

PCSK6 relationships Subject–Predicate–Object triples

TTTA extracted 111 structured relationships around PCSK6. Examples in this analysis include PCSK6 → Aliases → PCSK6, PACE4, SPC4, proprotein convertase subtilisin/kexin type 6 and PCSK6 → Band → 15q26.3. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
PCSK6AliasesPCSK6, PACE4, SPC4, proprotein convertase subtilisin/kexin type 61.00infobox
PCSK6Band15q26.31.00infobox
PCSK6Band7 C|7 35.36 cM1.00infobox
PCSK6BgeeC1 segment1.00infobox
PCSK6Bgeeliver1.00infobox
PCSK6Bgeeright lobe of liver1.00infobox
PCSK6Bgeemiddle frontal gyrus1.00infobox
PCSK6Bgeecorpus callosum1.00infobox
PCSK6Bgeespleen1.00infobox
PCSK6Bgeeinferior ganglion of vagus nerve1.00infobox
PCSK6Bgeeinferior olivary nucleus1.00infobox
PCSK6Bgeesynovial joint1.00infobox
PCSK6Bgeesubthalamic nucleus1.00infobox
PCSK6Bgeeankle1.00infobox
PCSK6BgeeDermatocranium1.00infobox
PCSK6Bgeecalvaria1.00infobox
PCSK6Bgeestria vascularis1.00infobox
PCSK6Bgeelip1.00infobox
PCSK6Bgeeesophagus1.00infobox
PCSK6Bgeeleft lobe of liver1.00infobox
PCSK6Bgeemembranous bone1.00infobox
PCSK6Bgeebody of femur1.00infobox
PCSK6Bgeecerebellar vermis1.00infobox
PCSK6BioGPSMore reference expression data1.00infobox
PCSK6Chr.Chromosome 15 (human)1.00infobox
PCSK6Chr.Chromosome 7 (mouse)1.00infobox
PCSK6DatabasesNCBI: entry; OMA: entry1.00infobox
PCSK6End101,525,202 bp1.00infobox
PCSK6End65,700,134 bp1.00infobox
PCSK6EnsemblENSG000001404791.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around PCSK6 bring nearby vocabulary together. In this analysis, examples include Gene, Bmp and Cardiovascular. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • PCSK6
    • Gene
    • Bmp
    • Cardiovascular
    • Found
    • Left
    • Factor
    • Proprotein
    • Chromosome
    • Function
    • Handedness
    • Right
    • Subtilisin
  • pcsk6
    • Gene
    • Bmp
    • Cardiovascular
    • Found
    • Left
    • Factor
    • Proprotein
    • Chromosome
    • Function
    • Handedness
    • Right
    • Subtilisin
  • gene
    • Chromosome
    • Location
    • Human
    • Proprotein
    • Bp
    • Chr
    • Function
    • Kexin
    • Mouse
    • Subtilisin
    • Type
    • Processing
  • chromosome 15
    • Human
    • Bp
    • Chr
    • Convertase
    • Location
    • Gene
    • Band
    • Proprotein
    • Function
    • Kexin
    • Mouse
    • Subtilisin
  • transforming growth factor β
    • Factor
    • Growth
    • Substrates
    • Corin
    • Process
    • Function
    • Mouse
    • Protein
    • Right
    • Axis
    • Bmp
    • Left
  • proprotein convertase
    • Proprotein
    • Function
    • Kexin
    • Subtilisin
    • Type
    • Chromosome
    • Encoded
    • Gene
    • Location
    • Human
    • Process
    • Bp
  • von willebrand factor
    • Growth
    • Substrates
    • Corin
    • Process
    • Function
    • Mouse
    • Protein
    • Right
    • Pcsk6
    • Axis
    • Bmp
    • Cardiovascular
  • function
    • Location
    • Human
    • Proprotein
    • Bp
    • Chr
    • Gene
    • Kexin
    • Mouse
    • Protein
    • Right
    • Subtilisin
    • Type

Connections between topic areas Semantic bridges

For PCSK6, one of the stronger structural bridges in this analysis connects PCSK6 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
PCSK6Overview · splits 11 ⟂ 13
PCSK6Function · splits 19 ⟂ 5
PCSK6Clinical significance · splits 19 ⟂ 5

Map overview Semantic statistics

PCSK6

Nodes24
Edges23
Triples111
Avg. degree1.92
Density0.083333
Components1

Source & methodology

TTTA analyzes the structure around PCSK6 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Clinical significance & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — PCSK6 · EN edition · Analysis: TopicsToTalkAbout

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