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PABPC1: Interactions, Function & Overview

Polyadenylate-binding protein 1 is a protein that in humans is encoded by the PABPC1 gene. The protein PABP1 binds mRNA and facilitates a variety of functions such as transport into and out of the nucleus, degradation, translation, and stability. There are two separate PABP1 proteins, one which is located in the nucleus (PABPN1) and the other which is…

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PABPC1 topic overview

The analysis highlights Interactions, Function and Overview as prominent areas in the source structure around PABPC1.

Related topics
12
Source areas
3
Connected nodes
15
Extracted relationships
123
Concept neighborhoods
7
Bridge connections
15

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Interactions · 8 topics
Function · 2 topics
Overview · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
PABPC1, PAB1, PABP, PABP1, PABPC2, PABPL1, poly(A) binding protein cytoplasmic 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1CVJ, 1G9L, 1JGN, 1JH4, 2K8G, 2RQG, 2RQH, 2X04, 3KTP, 3KTR, 3KUI, 3KUJ, 3KUR, 3KUS, 3KUT, 3PKN, 3PTH, 4F02,…
Band
8q22.3 · 15|15 B3.1
Bgee
parotid gland · pylorus · gonad · amniotic fluid · vulva
BioGPS
n/a
Chr.
Chromosome 8 (human) · Chromosome 15 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How PABPC1 connects Entity context

The extracted context around PABPC1 shows recurring relationship patterns in the source. For example, PABPC1 → catalytic step 2 spliceosome, cytoplasm, cytoplasmic ribonucleoprotein granule, cytoplasmic stress granule, cytosol, dendrite, extracellular exosome, focal adhesion, gene silencing, membrane, messenger ribonucleoprotein complex, mRNA 3'-UTR binding, mRNA binding, mRNA polyadenylation, mRNA processing, mRNA splicing, via spliceosome, mRNA stabilization, negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, nuclear-transcribed mRNA poly(A) tail shortening Another extracted example is PABPC1 → amniotic fluid, embryo, genital tubercle, gonad, lip, monocyte, morula, neural layer of retina, nipple, oral cavity, parotid gland, pylorus, spermatid, spermatocyte, tail of embryo, tonsil, trabecular bone, ventricular zone, vulva, yolk sac. Use these groups to spot repeated connection types before inspecting the individual relationships.

PABPC1

Top relations

Gene ontology · 39
PABPC1 → catalytic step 2 spliceosome, cytoplasm, cytoplasmic ribonucleoprotein granule, cytoplasmic stress granule, cytosol, dendrite, extracellular exosome, focal adhesion, gene silencing, membrane, messenger ribonucleoprotein complex, mRNA 3'-UTR binding, mRNA binding, mRNA polyadenylation, mRNA processing, mRNA splicing, via spliceosome, mRNA stabilization, negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, nuclear-transcribed mRNA poly(A) tail shortening
Bgee · 20
PABPC1 → amniotic fluid, embryo, genital tubercle, gonad, lip, monocyte, morula, neural layer of retina, nipple, oral cavity, parotid gland, pylorus, spermatid, spermatocyte, tail of embryo, tonsil, trabecular bone, ventricular zone, vulva, yolk sac
RNA expression pattern · 20
PABPC1 → amniotic fluid, embryo, genital tubercle, gonad, lip, monocyte, morula, neural layer of retina, nipple, oral cavity, parotid gland, pylorus, spermatid, spermatocyte, tail of embryo, tonsil, trabecular bone, ventricular zone, vulva, yolk sac
related to Function · 7
PABPC1 → In, NMD, PAB, PABP, PABPs, The, This
related to Interactions · 6
PABPC1 → ANAPC5, CNOT7, EIF4G1, EIF4G3, GSPT2, PAIP1
Band · 2
PABPC1 → 15|15 B3.1, 8q22.3
Chr. · 2
PABPC1 → Chromosome 15 (mouse), Chromosome 8 (human)
End · 2
PABPC1 → 100,722,809 bp, 36,609,912 bp
Aliases · 1
PABPC1 → PABPC1, PAB1, PABP, PABP1, PABPC2, PABPL1, poly(A) binding protein cytoplasmic 1
Available structures · 1
PABPC1 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1CVJ, 1G9L, 1JGN, 1JH4, 2K8G, 2RQG, 2RQH, 2X04, 3KTP, 3KTR, 3KUI, 3KUJ, 3KUR, 3KUS, 3KUT, 3PKN, 3PTH, 4F02,…

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

protein mrna pabp1 bp poly gene nucleus chr human band location chromosome function cytoplasm tail translation stability binds degradation binding

PABPC1 relationships Subject–Predicate–Object triples

TTTA extracted 123 structured relationships around PABPC1. Examples in this analysis include PABPC1 → Aliases → PABPC1, PAB1, PABP, PABP1, PABPC2, PABPL1, poly(A) binding protein cytoplasmic 1 and PABPC1 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1CVJ, 1G9L, 1JGN, 1JH4, 2K8G, 2RQG, 2RQH, 2X04, 3KTP, 3KTR, 3KUI, 3KUJ, 3KUR, 3KUS, 3KUT, 3PKN, 3PTH, 4F02,…. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
PABPC1AliasesPABPC1, PAB1, PABP, PABP1, PABPC2, PABPL1, poly(A) binding protein cytoplasmic 11.00infobox
PABPC1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1CVJ, 1G9L, 1JGN, 1JH4, 2K8G, 2RQG, 2RQH, 2X04, 3KTP, 3KTR, 3KUI, 3KUJ, 3KUR, 3KUS, 3KUT, 3PKN, 3PTH, 4F02,…1.00infobox
PABPC1Band8q22.31.00infobox
PABPC1Band15|15 B3.11.00infobox
PABPC1Bgeeparotid gland1.00infobox
PABPC1Bgeepylorus1.00infobox
PABPC1Bgeegonad1.00infobox
PABPC1Bgeeamniotic fluid1.00infobox
PABPC1Bgeevulva1.00infobox
PABPC1Bgeetonsil1.00infobox
PABPC1Bgeenipple1.00infobox
PABPC1Bgeetrabecular bone1.00infobox
PABPC1Bgeemonocyte1.00infobox
PABPC1Bgeeoral cavity1.00infobox
PABPC1Bgeetail of embryo1.00infobox
PABPC1Bgeegenital tubercle1.00infobox
PABPC1Bgeeventricular zone1.00infobox
PABPC1Bgeeyolk sac1.00infobox
PABPC1Bgeespermatocyte1.00infobox
PABPC1Bgeemorula1.00infobox
PABPC1Bgeeneural layer of retina1.00infobox
PABPC1Bgeespermatid1.00infobox
PABPC1Bgeeembryo1.00infobox
PABPC1Bgeelip1.00infobox
PABPC1BioGPSn/a1.00infobox
PABPC1Chr.Chromosome 8 (human)1.00infobox
PABPC1Chr.Chromosome 15 (mouse)1.00infobox
PABPC1DatabasesNCBI: entry; OMA: entry1.00infobox
PABPC1End100,722,809 bp1.00infobox
PABPC1End36,609,912 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around PABPC1 bring nearby vocabulary together. In this analysis, examples include Cytoplasm, Gene and Protein. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • PABPC1
    • Cytoplasm
    • Gene
    • Protein
    • Poly
    • Mrna
    • Cytoplasmic
    • Found
    • Search
    • Binding
    • Decay
    • Function
    • Nonsense-mediated
  • pabpc1
    • Cytoplasm
    • Gene
    • Protein
    • Poly
    • Mrna
    • Cytoplasmic
    • Found
    • Search
    • Binding
    • Decay
    • Function
    • Nonsense-mediated
  • protein
    • Function
    • Location
    • Cytoplasmic
    • Rna
    • Search
    • Translation
    • Binding
    • Stability
    • Chromosome
    • Human
    • Bp
    • Chr
  • gene
    • Chromosome
    • Human
    • Location
    • Bp
    • Chr
    • Protein
    • B3
    • Cytoplasmic
    • End
    • Humans
    • Mouse
    • Search
  • function
    • Location
    • Cytoplasmic
    • Rna
    • Search
    • Protein
    • Binding
    • Chromosome
    • Human
    • Bp
    • Chr
    • Gene
    • Pabp1
  • nonsense-mediated decay
    • Nonsense-mediated
    • Required
    • End
    • Found
    • Mouse
    • Mrna
    • Rna
    • Search
    • Translation
    • Function
    • Pabpc1
    • Stability
  • poly(a)-binding proteins
    • Tail
    • Found
    • Search
    • Two
    • Stability
    • Cytoplasm
    • Protein
    • B3
    • End
    • Mouse
    • Poly
    • Proteins

Connections between topic areas Semantic bridges

For PABPC1, one of the stronger structural bridges in this analysis connects PABPC1 with Interactions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
PABPC1Interactions · splits 7 ⟂ 9
PABPC1Overview · splits 13 ⟂ 3
PABPC1Function · splits 13 ⟂ 3

Map overview Semantic statistics

PABPC1

Nodes16
Edges15
Triples123
Avg. degree1.88
Density0.125
Components1

Source & methodology

TTTA analyzes the structure around PABPC1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Interactions, Function & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — PABPC1 · EN edition · Analysis: TopicsToTalkAbout

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