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OXGR1: History, OXGR1 activating and inhibiting ligands & Functions

OXGR1, i.e., 2-oxoglutarate receptor 1 (also known as GPR99, cysteinyl leukotriene receptor E, i.e., CysLTE, and cysteinyl leukotriene receptor 3, i.e., CysLT3) is a G protein-coupled receptor located on the surface membranes of certain cells. It functions by binding one of its ligands and thereby becoming active in triggering pre-programmed responses in…

Language: English [EN]
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OXGR1 topic overview

The analysis highlights History, OXGR1 activating and inhibiting ligands and Functions as prominent areas in the source structure around OXGR1.

Related topics
94
Source areas
6
Connected nodes
100
Extracted relationships
147
Concept neighborhoods
30
Bridge connections
100

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 31 topics
OXGR1 activating and inhibiting ligands · 19 topics
Functions · 14 topics
History · 14 topics
Expression · 12 topics
OXGR1 gene · 4 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
OXGR1, GPR80, GPR99, P2RY15, P2Y15, aKGR, oxoglutarate receptor 1
Band
13q32.1 · 14|14 E4
Bgee
islet of Langerhans · Achilles tendon · minor salivary glands · olfactory zone of nasal mucosa · rectum
BioGPS
More reference expression data
Chr.
Chromosome 13 (human) · Chromosome 14 (mouse)
Databases
NCBI: entry; OMA: entry

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

History

OXGR1 gene

OXGR1 activating and inhibiting ligands

Expression

Functions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How OXGR1 connects Entity context

The extracted context around OXGR1 shows recurring relationship patterns in the source. For example, OXGR1 → Classification, Finally, GPR80, GPR80/GPR99, GPR91, GPR99, However, In, International Union, Its, IUPHAR, LTC4, LTD4, LTE4, P2Y, P2Y Receptor Nomenclature, P2Y1, P2Y15, Pharmacology Subcommittee, Shortly Another extracted example is OXGR1 → Alternaria, American, Another, Control, Csltr1, Cstlr2, Cysltr1, Cysltr2, Dermatophagoides, LTC4, LTD4, LTE4, LTE4's, LTE4-induced OXGR1, LTE4-OXGR1, LTF4, LTs, Studies, The, These. Use these groups to spot repeated connection types before inspecting the individual relationships.

OXGR1

Top relations

related to history · 22
OXGR1 → Classification, Finally, GPR80, GPR80/GPR99, GPR91, GPR99, However, In, International Union, Its, IUPHAR, LTC4, LTD4, LTE4, P2Y, P2Y Receptor Nomenclature, P2Y1, P2Y15, Pharmacology Subcommittee, Shortly
related to Associated with LTE4-induced functions · 21
OXGR1 → Alternaria, American, Another, Control, Csltr1, Cstlr2, Cysltr1, Cysltr2, Dermatophagoides, LTC4, LTD4, LTE4, LTE4's, LTE4-induced OXGR1, LTE4-OXGR1, LTF4, LTs, Studies, The, These
Bgee · 19
OXGR1 → Achilles tendon, appendix, central gray substance of midbrain, extraocular muscle, human kidney, islet of Langerhans, lumbar spinal ganglion, lumbar subsegment of spinal cord, metanephros, minor salivary glands, olfactory zone of nasal mucosa, rectum, renal cortex, right kidney, right uterine tube, skin of abdomen, skin of leg, spermatid, spermatocyte
RNA expression pattern · 19
OXGR1 → Achilles tendon, appendix, central gray substance of midbrain, extraocular muscle, human kidney, islet of Langerhans, lumbar spinal ganglion, lumbar subsegment of spinal cord, metanephros, minor salivary glands, olfactory zone of nasal mucosa, rectum, renal cortex, right kidney, right uterine tube, skin of abdomen, skin of leg, spermatid, spermatocyte
related to Inhibiting ligand · 14
OXGR1 → CysLTR1, CysLTR2, CysTR2, Functions, In, Inhibitors, It, LTC4, LTD4, LTE4, Montelukast, Montelukast's, OXGR1's, While
Gene ontology · 7
OXGR1 → G protein-coupled receptor activity, G protein-coupled receptor signaling pathway, integral component of membrane, membrane, plasma membrane, signal transducer activity, signal transduction
related to Associated with itaconate-regulated functions · 5
OXGR1 → Ca2, Itaconate, Pseudomonas, The, This
related to Activating ligands · 4
OXGR1 → LTC4, LTD4, LTE4, These
related to OXGR1 gene · 4
OXGR1 → Functions, Gq, The, When
related to Associated with OXGR1 gene defects or deficiencies · 3
OXGR1 → It, OXGR1's, The

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene cells receptor study itaconate mice lte4 ltc4 ltd4 human α-ketoglutarate protein responses knockout functions nasal cysltr1 bp band also

OXGR1 relationships Subject–Predicate–Object triples

TTTA extracted 147 structured relationships around OXGR1. Examples in this analysis include OXGR1 → Aliases → OXGR1, GPR80, GPR99, P2RY15, P2Y15, aKGR, oxoglutarate receptor 1 and OXGR1 → Band → 13q32.1. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
OXGR1AliasesOXGR1, GPR80, GPR99, P2RY15, P2Y15, aKGR, oxoglutarate receptor 11.00infobox
OXGR1Band13q32.11.00infobox
OXGR1Band14|14 E41.00infobox
OXGR1Bgeeislet of Langerhans1.00infobox
OXGR1BgeeAchilles tendon1.00infobox
OXGR1Bgeeminor salivary glands1.00infobox
OXGR1Bgeeolfactory zone of nasal mucosa1.00infobox
OXGR1Bgeerectum1.00infobox
OXGR1Bgeehuman kidney1.00infobox
OXGR1Bgeeskin of leg1.00infobox
OXGR1Bgeeappendix1.00infobox
OXGR1Bgeeright uterine tube1.00infobox
OXGR1Bgeeskin of abdomen1.00infobox
OXGR1Bgeeright kidney1.00infobox
OXGR1Bgeelumbar subsegment of spinal cord1.00infobox
OXGR1Bgeespermatocyte1.00infobox
OXGR1Bgeespermatid1.00infobox
OXGR1Bgeerenal cortex1.00infobox
OXGR1Bgeeextraocular muscle1.00infobox
OXGR1Bgeelumbar spinal ganglion1.00infobox
OXGR1Bgeemetanephros1.00infobox
OXGR1Bgeecentral gray substance of midbrain1.00infobox
OXGR1BioGPSMore reference expression data1.00infobox
OXGR1Chr.Chromosome 13 (human)1.00infobox
OXGR1Chr.Chromosome 14 (mouse)1.00infobox
OXGR1DatabasesNCBI: entry; OMA: entry1.00infobox
OXGR1End96,994,730 bp1.00infobox
OXGR1End120,279,847 bp1.00infobox
OXGR1EnsemblENSG000001656211.00infobox
OXGR1Entrez271991.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around OXGR1 bring nearby vocabulary together. In this analysis, examples include Gene, Lte4 and Mice. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • OXGR1
    • Gene
    • Lte4
    • Mice
    • Cells
    • Ltc4
    • Ltd4
    • Protein
    • Itaconate
    • Receptor
    • Study
    • Knockout
    • Functions
  • oxgr1
    • Gene
    • Lte4
    • Mice
    • Cells
    • Ltc4
    • Ltd4
    • Protein
    • Itaconate
    • Receptor
    • Study
    • Knockout
    • Functions
  • goblet cells
    • Nasal
    • Mice
    • Oxgr1
    • Gene
    • Human
    • Mucosa
    • Responses
    • Knockout
    • Protein
    • Epithelial
    • Gpr99
    • Kidney
  • functions of the gq alpha pathways
    • Ligands
    • Kidney
    • Oxgr1
    • Studies
    • Mice
    • Human
    • Responses
    • Epithelial
    • Study
    • Bp
    • Chr
    • Chromosome
  • functions of cysltr1
    • Cysltr2
    • Ligands
    • Receptors
    • Lte4
    • Responses
    • Ltc4
    • Ltd4
    • Mice
    • Kidney
    • Oxgr1
    • Actions
    • Studies
  • mast cells
    • Nasal
    • Mice
    • Oxgr1
    • Gene
    • Human
    • Mucosa
    • Responses
    • Knockout
    • Protein
    • Epithelial
    • Gpr99
    • Kidney
  • oxgr1 receptor-dependent bioactions of α-ketoglutarate
    • Α-ketoglutaric
    • Gene
    • Lte4
    • Mice
    • Cells
    • Ltc4
    • Ltd4
    • Protein
    • Itaconate
    • Receptor
    • Study
    • Knockout
  • oxgr1 gene
    • Knockout
    • Mice
    • Gene
    • Oxgr1
    • Human
    • Lte4
    • Cells
    • Protein
    • Chromosome
    • Receptor
    • Ltc4
    • Ltd4

Connections between topic areas Semantic bridges

For OXGR1, one of the stronger structural bridges in this analysis connects OXGR1 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
OXGR1Overview · splits 69 ⟂ 32
OXGR1OXGR1 activating and inhibiting ligands · splits 81 ⟂ 20
OXGR1History · splits 86 ⟂ 15
OXGR1Functions · splits 86 ⟂ 15
OXGR1Expression · splits 88 ⟂ 13
OXGR1OXGR1 gene · splits 96 ⟂ 5

Map overview Semantic statistics

OXGR1

Nodes101
Edges100
Triples147
Avg. degree1.98
Density0.019802
Components1

Source & methodology

TTTA analyzes the structure around OXGR1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, OXGR1 activating and inhibiting ligands & Functions, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — OXGR1 · EN edition · Analysis: TopicsToTalkAbout

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