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Neprilysin: Signaling peptides, Immunochemistry & Inhibitors

Neprilysin (/ˌnɛprɪˈlaɪsɪn/; also known as membrane metallo-endopeptidase (MME), neutral endopeptidase (NEP), cluster of differentiation 10 (CD10) and common acute lymphoblastic leukemia antigen (CALLA)) is an enzyme that in humans is encoded by the MME gene. Neprilysin is a zinc-dependent metalloprotease that cleaves peptides at the amino side of…

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Neprilysin topic overview

The analysis highlights Signaling peptides, Immunochemistry and Inhibitors as prominent areas in the source structure around Neprilysin.

Related topics
81
Source areas
5
Connected nodes
86
Extracted relationships
150
Related term clusters
35
Bridge connections
86

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 27 topics
Signaling peptides · 19 topics
Immunochemistry · 17 topics
Inhibitors · 13 topics
Amyloid beta regulation · 5 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3.4.24.11
↗
Aliases
MME, CALLA, CD10, NEP, SFE, membrane metallo-endopeptidase, membrane metalloendopeptidase, CMT2T, SCA43
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1DMT, 1R1H, 1R1I, 1R1J, 1Y8J, 2QPJ, 2YB9, 4CTH, 5JMY
Band
3q25.2 · 3 E1|3 29.97 cM
Bgee
jejunal mucosa · glomerulus · metanephric glomerulus · stromal cell of endometrium · duodenum
BioGPS
More reference expression data

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Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Amyloid beta regulation

Signaling peptides

Inhibitors

Immunochemistry

For the semantics nerds

You can skip this section if you’re here for content ideas and keyword inspiration.

Advanced semantic analysis

How Neprilysin connects Entity context

The extracted context around Neprilysin shows recurring relationship patterns in the source. For example, Neprilysin → ageing, amyloid-beta clearance, amyloid-beta clearance by cellular catabolic process, amyloid-beta metabolic process, angiotensin maturation, axon, brush border, cardiolipin binding, cell surface, cellular response to cytokine stimulus, cellular response to UV-A, cellular response to UV-B, creatinine metabolic process, cytoplasm, cytoplasmic vesicle, dendrite, early endosome, endopeptidase activity, exopeptidase activity, extracellular exosome Another extracted example is Neprilysin → blood, calvaria, duodenum, epithelium of lens, external carotid artery, glomerulus, Gonadal ridge, human kidney, jejunal mucosa, kidney tubule, lobe of prostate, metanephric glomerulus, molar, mucosa of ileum, prostate, stromal cell of endometrium, sural nerve, vas deferens, vestibular membrane of cochlear duct, vestibular sensory epithelium. Use these groups to spot repeated connection types before inspecting the individual relationships.

Neprilysin

Top relations

Gene ontology · 56
Neprilysin → ageing, amyloid-beta clearance, amyloid-beta clearance by cellular catabolic process, amyloid-beta metabolic process, angiotensin maturation, axon, brush border, cardiolipin binding, cell surface, cellular response to cytokine stimulus, cellular response to UV-A, cellular response to UV-B, creatinine metabolic process, cytoplasm, cytoplasmic vesicle, dendrite, early endosome, endopeptidase activity, exopeptidase activity, extracellular exosome
Bgee · 20
Neprilysin → blood, calvaria, duodenum, epithelium of lens, external carotid artery, glomerulus, Gonadal ridge, human kidney, jejunal mucosa, kidney tubule, lobe of prostate, metanephric glomerulus, molar, mucosa of ileum, prostate, stromal cell of endometrium, sural nerve, vas deferens, vestibular membrane of cochlear duct, vestibular sensory epithelium
RNA expression pattern · 20
Neprilysin → blood, calvaria, duodenum, epithelium of lens, external carotid artery, glomerulus, Gonadal ridge, human kidney, jejunal mucosa, kidney tubule, lobe of prostate, metanephric glomerulus, molar, mucosa of ileum, prostate, stromal cell of endometrium, sural nerve, vas deferens, vestibular membrane of cochlear duct, vestibular sensory epithelium
related to Signaling peptides · 8
Neprilysin → Associations, CALLA, CD10, Ceropegia, Inhibitors, Kniphofia, Pavetta, Plectranthus
related to Amyloid beta regulation · 4
Neprilysin → Alzheimer's, Alzheimer's-like, Declining, Neprilysin-deficient
Band · 2
Neprilysin → 3 E1|3 29.97 cM, 3q25.2
Chr. · 2
Neprilysin → Chromosome 3 (human), Chromosome 3 (mouse)
End · 2
Neprilysin → 155,183,704 bp, 63,293,451 bp
3.4.24.11 · 1
Neprilysin → ↗
Aliases · 1
Neprilysin → MME, CALLA, CD10, NEP, SFE, membrane metallo-endopeptidase, membrane metalloendopeptidase, CMT2T, SCA43

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

cd10 cell carcinoma cells leukemia lymphoma also human bp peptide activity expression gene chr band follicular acute peptides cancer expressed

Neprilysin relationships Subject–Predicate–Object triples

TTTA extracted 150 structured relationships around Neprilysin. Examples in this analysis include Neprilysin → 3.4.24.11 → ↗ and Neprilysin → Aliases → MME, CALLA, CD10, NEP, SFE, membrane metallo-endopeptidase, membrane metalloendopeptidase, CMT2T, SCA43. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Neprilysin3.4.24.11↗1.00infobox
NeprilysinAliasesMME, CALLA, CD10, NEP, SFE, membrane metallo-endopeptidase, membrane metalloendopeptidase, CMT2T, SCA431.00infobox
NeprilysinAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1DMT, 1R1H, 1R1I, 1R1J, 1Y8J, 2QPJ, 2YB9, 4CTH, 5JMY1.00infobox
NeprilysinBand3q25.21.00infobox
NeprilysinBand3 E1|3 29.97 cM1.00infobox
NeprilysinBgeejejunal mucosa1.00infobox
NeprilysinBgeeglomerulus1.00infobox
NeprilysinBgeemetanephric glomerulus1.00infobox
NeprilysinBgeestromal cell of endometrium1.00infobox
NeprilysinBgeeduodenum1.00infobox
NeprilysinBgeekidney tubule1.00infobox
NeprilysinBgeesural nerve1.00infobox
NeprilysinBgeehuman kidney1.00infobox
NeprilysinBgeemucosa of ileum1.00infobox
NeprilysinBgeeblood1.00infobox
NeprilysinBgeeepithelium of lens1.00infobox
NeprilysinBgeemolar1.00infobox
NeprilysinBgeevestibular sensory epithelium1.00infobox
NeprilysinBgeeprostate1.00infobox
NeprilysinBgeeGonadal ridge1.00infobox
NeprilysinBgeelobe of prostate1.00infobox
NeprilysinBgeevestibular membrane of cochlear duct1.00infobox
NeprilysinBgeeexternal carotid artery1.00infobox
NeprilysinBgeecalvaria1.00infobox
NeprilysinBgeevas deferens1.00infobox
NeprilysinBioGPSMore reference expression data1.00infobox
NeprilysinChr.Chromosome 3 (human)1.00infobox
NeprilysinChr.Chromosome 3 (mouse)1.00infobox
NeprilysinDatabasesNCBI: entry; OMA: entry1.00infobox
NeprilysinEnd155,183,704 bp1.00infobox

Related concept clusters Related term clusters

The concept neighborhoods around Neprilysin bring nearby vocabulary together. In this analysis, examples include Cancer, Expressed and Peptides. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • angioimmunoblastic t cell lymphoma
    • Carcinoma
    • Lymphoma
    • Follicular
    • Surface
    • Leukemia
    • Cells
    • Diagnosis
    • Protein
    • Human
    • May
    • Tumors
    • Pre-b
  • hairy cell leukemia
    • Carcinoma
    • Lymphoma
    • Burkitt
    • Follicular
    • Cells
    • Surface
    • Cell
    • Leukemia
    • Diagnosis
    • Protein
    • Enzyme
    • Membrane
  • mantle cell lymphoma
    • Carcinoma
    • Lymphoma
    • Follicular
    • Surface
    • Leukemia
    • Cells
    • Diagnosis
    • Protein
    • Human
    • May
    • Tumors
    • Pre-b
  • clear cell renal cell carcinoma
    • Carcinoma
    • Cell
    • Cd10
    • Lymphoma
    • Follicular
    • Surface
    • Tumor
    • Expression
    • Leukemia
    • Cells
    • Diagnosis
    • May
  • basal cell carcinoma
    • Carcinoma
    • Cell
    • Cd10
    • Lymphoma
    • Follicular
    • Surface
    • Tumor
    • Expression
    • Leukemia
    • Cells
    • Diagnosis
    • May
  • squamous cell carcinoma
    • Carcinoma
    • Cell
    • Cd10
    • Lymphoma
    • Follicular
    • Surface
    • Tumor
    • Expression
    • Leukemia
    • Cells
    • Diagnosis
    • May
  • renal cell carcinoma
    • Carcinoma
    • Cell
    • Cd10
    • Lymphoma
    • Follicular
    • Surface
    • Tumor
    • Expression
    • Leukemia
    • Cells
    • Diagnosis
    • May
  • pancreatic tumors
    • Considered
    • Germinal
    • Tumor
    • Expression
    • Cd10
    • Enzyme
    • Membrane
    • Mme
    • Carcinoma
    • Chromosome
    • Nep
    • Signaling

Connections between topic areas Semantic bridges

For Neprilysin, one of the stronger structural bridges in this analysis connects Neprilysin with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Neprilysin — Overview · splits 59 ⟂ 28
Neprilysin — Signaling peptides · splits 67 ⟂ 20
Neprilysin — Immunochemistry · splits 69 ⟂ 18
Neprilysin — Inhibitors · splits 73 ⟂ 14
Neprilysin — Amyloid beta regulation · splits 81 ⟂ 6

Map overview Semantic statistics

Neprilysin

Nodes87
Edges86
Triples150
Avg. degree1.98
Density0.022989
Components1

Source & methodology

TTTA analyzes the structure around Neprilysin to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Signaling peptides, Immunochemistry & Inhibitors, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Neprilysin · EN edition · Analysis: TopicsToTalkAbout

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