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Neprilysin (/ˌnɛprɪˈlaɪsɪn/; also known as membrane metallo-endopeptidase (MME), neutral endopeptidase (NEP), cluster of differentiation 10 (CD10) and common acute lymphoblastic leukemia antigen (CALLA)) is an enzyme that in humans is encoded by the MME gene. Neprilysin is a zinc-dependent metalloprotease that cleaves peptides at the amino side of…
The analysis highlights Immunochemistry, Signaling peptides and Inhibitors as prominent areas in the source structure around Neprilysin.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around Neprilysin shows recurring relationship patterns in the source. For example, Neprilysin → ageing, amyloid-beta clearance, amyloid-beta clearance by cellular catabolic process, amyloid-beta metabolic process, angiotensin maturation, axon, brush border, cardiolipin binding, cell surface, cellular response to cytokine stimulus, cellular response to UV-A, cellular response to UV-B, creatinine metabolic process, cytoplasm, cytoplasmic vesicle, dendrite, early endosome, endopeptidase activity, exopeptidase activity, extracellular exosome Another extracted example is Neprilysin → blood, calvaria, duodenum, epithelium of lens, external carotid artery, glomerulus, Gonadal ridge, human kidney, jejunal mucosa, kidney tubule, lobe of prostate, metanephric glomerulus, molar, mucosa of ileum, prostate, stromal cell of endometrium, sural nerve, vas deferens, vestibular membrane of cochlear duct, vestibular sensory epithelium. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
cd10 cell carcinoma cells leukemia lymphoma also human bp peptide activity expression gene chr band follicular acute peptides cancer expressed
TTTA extracted 169 structured relationships around Neprilysin. Examples in this analysis include Neprilysin → 3.4.24.11 → ↗ and Neprilysin → Aliases → MME, CALLA, CD10, NEP, SFE, membrane metallo-endopeptidase, membrane metalloendopeptidase, CMT2T, SCA43. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| Neprilysin | 3.4.24.11 | ↗ | 1.00 | infobox |
| Neprilysin | Aliases | MME, CALLA, CD10, NEP, SFE, membrane metallo-endopeptidase, membrane metalloendopeptidase, CMT2T, SCA43 | 1.00 | infobox |
| Neprilysin | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1DMT, 1R1H, 1R1I, 1R1J, 1Y8J, 2QPJ, 2YB9, 4CTH, 5JMY | 1.00 | infobox |
| Neprilysin | Band | 3q25.2 | 1.00 | infobox |
| Neprilysin | Band | 3 E1|3 29.97 cM | 1.00 | infobox |
| Neprilysin | Bgee | jejunal mucosa | 1.00 | infobox |
| Neprilysin | Bgee | glomerulus | 1.00 | infobox |
| Neprilysin | Bgee | metanephric glomerulus | 1.00 | infobox |
| Neprilysin | Bgee | stromal cell of endometrium | 1.00 | infobox |
| Neprilysin | Bgee | duodenum | 1.00 | infobox |
| Neprilysin | Bgee | kidney tubule | 1.00 | infobox |
| Neprilysin | Bgee | sural nerve | 1.00 | infobox |
| Neprilysin | Bgee | human kidney | 1.00 | infobox |
| Neprilysin | Bgee | mucosa of ileum | 1.00 | infobox |
| Neprilysin | Bgee | blood | 1.00 | infobox |
| Neprilysin | Bgee | epithelium of lens | 1.00 | infobox |
| Neprilysin | Bgee | molar | 1.00 | infobox |
| Neprilysin | Bgee | vestibular sensory epithelium | 1.00 | infobox |
| Neprilysin | Bgee | prostate | 1.00 | infobox |
| Neprilysin | Bgee | Gonadal ridge | 1.00 | infobox |
| Neprilysin | Bgee | lobe of prostate | 1.00 | infobox |
| Neprilysin | Bgee | vestibular membrane of cochlear duct | 1.00 | infobox |
| Neprilysin | Bgee | external carotid artery | 1.00 | infobox |
| Neprilysin | Bgee | calvaria | 1.00 | infobox |
| Neprilysin | Bgee | vas deferens | 1.00 | infobox |
| Neprilysin | BioGPS | More reference expression data | 1.00 | infobox |
| Neprilysin | Chr. | Chromosome 3 (human) | 1.00 | infobox |
| Neprilysin | Chr. | Chromosome 3 (mouse) | 1.00 | infobox |
| Neprilysin | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| Neprilysin | End | 155,183,704 bp | 1.00 | infobox |
The concept neighborhoods around Neprilysin bring nearby vocabulary together. In this analysis, examples include Cancer, Expressed and Peptides. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For Neprilysin, one of the stronger structural bridges in this analysis connects Neprilysin with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around Neprilysin to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Immunochemistry, Signaling peptides & Inhibitors, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — Neprilysin · EN edition · Analysis: TopicsToTalkAbout