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MEF2B

Myocyte enhancer binding factor 2B (MEF2B) is a transcription factor part of the MEF2 gene family including MEF2A, MEF2C, and MEF2D. However, MEF2B is distant from the other three branches of MEF2 genes as it lacks the protein-coding Holliday junction recognition protein C-terminal (HJURP_C) region in vertebrates.

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Interactions

InteractCABIN1
2 related topics

Clinical relevance

Diffuse large B-cell lymphoma
1 related topics

Overview

MEF2AMEF2CMEF2D
3 related topics

Key facts & relationships

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Aliases
BORCS8-MEF2B, LOC729991-MEF2B, MEF2B, MEF2BNB-MEF2B, BORCS8-MEF2B readthrough, RSRFR2
Available structures
Available structuresPDBHuman UniProt search: PDBe RCSB List of PDB id codes1N6J, 1TQE
Databases
NCBI: entry; OMA: entry
Ensembl
ENSG00000064489
Entrez
4207
External IDs
GeneCards: BORCS8-MEF2B

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Overview

Interactions

Clinical relevance

Advanced semantic analysis

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Map overview Semantic statistics

MEF2B

Nodes10
Edges9
Triples44
Avg. degree1.8
Density0.2
Components1

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MEF2B

Top relations

Gene ontology · 15
MEF2B → DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, histone deacetylase binding, muscle organ development, nucleus, positive regulation of transcription by RNA polymerase II, protein dimerization activity, regulation of transcription, DNA-templated, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, transcription by RNA polymerase II, transcription regulator complex, transcription, DNA-templated
related to Clinical relevance · 7
MEF2B → B-cell, BCL6, CABIN1, DLBCL, In, Mutations, Recurrent
related to Functions · 4
MEF2B → A/T-rich, Overexpression, SMHC, The MEF2
related to External links · 3
MEF2B → Medicine Medical Subject Headings, MeSH, National Library
Aliases · 1
MEF2B → BORCS8-MEF2B, LOC729991-MEF2B, MEF2B, MEF2BNB-MEF2B, BORCS8-MEF2B readthrough, RSRFR2
Available structures · 1
MEF2B → Available structuresPDBHuman UniProt search: PDBe RCSB List of PDB id codes1N6J, 1TQE
Databases · 1
MEF2B → NCBI: entry; OMA: entry
Ensembl · 1
MEF2B → ENSG00000064489
Entrez · 1
MEF2B → 4207
External IDs · 1
MEF2B → GeneCards: BORCS8-MEF2B

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Important terminology

gene mef2 protein muscle binding factor transcription region external smooth family cabin1 human activity development regulation mrna mef2a mef2c mef2d

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
MEF2BAliasesBORCS8-MEF2B, LOC729991-MEF2B, MEF2B, MEF2BNB-MEF2B, BORCS8-MEF2B readthrough, RSRFR21.00infobox
MEF2BAvailable structuresAvailable structuresPDBHuman UniProt search: PDBe RCSB List of PDB id codes1N6J, 1TQE1.00infobox
MEF2BDatabasesNCBI: entry; OMA: entry1.00infobox
MEF2BEnsemblENSG000000644891.00infobox
MEF2BEntrez42071.00infobox
MEF2BExternal IDsGeneCards: BORCS8-MEF2B1.00infobox
MEF2BGene ontologyDNA-binding transcription factor activity1.00infobox
MEF2BGene ontologyRNA polymerase II cis-regulatory region sequence-specific DNA binding1.00infobox
MEF2BGene ontologyDNA binding1.00infobox
MEF2BGene ontologyDNA-binding transcription activator activity, RNA polymerase II-specific1.00infobox
MEF2BGene ontologyhistone deacetylase binding1.00infobox
MEF2BGene ontologyprotein dimerization activity1.00infobox
MEF2BGene ontologyRNA polymerase II transcription regulatory region sequence-specific DNA binding1.00infobox
MEF2BGene ontologyDNA-binding transcription factor activity, RNA polymerase II-specific1.00infobox
MEF2BGene ontologynucleus1.00infobox
MEF2BGene ontologytranscription regulator complex1.00infobox
MEF2BGene ontologymuscle organ development1.00infobox
MEF2BGene ontologyregulation of transcription, DNA-templated1.00infobox
MEF2BGene ontologytranscription, DNA-templated1.00infobox
MEF2BGene ontologytranscription by RNA polymerase II1.00infobox
MEF2BGene ontologypositive regulation of transcription by RNA polymerase II1.00infobox
MEF2BList of PDB id codesList of PDB id codes1N6J, 1TQE1.00infobox
MEF2BLocation (UCSC)n/a1.00infobox
MEF2BOrthologsOrthologsDatabasesNCBI: entry; OMA: entrySpeciesHumanMouseEntrez4207n/aEnsemblENSG00000064489n/aUniProtQ02080n/aRefSeq (mRNA)NM_005919n/aRefSeq (protein)NP_001139257 NP_00135421…1.00infobox
MEF2BPDBHuman UniProt search: PDBe RCSB1.00infobox
MEF2BRefSeq (mRNA)NM_0059191.00infobox
MEF2BRefSeq (protein)NP_001139257 NP_001354211 NP_005910.11.00infobox
MEF2BSpeciesHuman1.00infobox
MEF2BUniProtQ020801.00infobox

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