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Naltrexone

Naltrexone, sold under the brand name Revia among others, is a medication primarily used to manage alcohol use and opioid use disorders by reducing cravings and feelings of euphoria associated with substance use disorder. It has also been found to be effective for the treatment of other addictions and may be used for them off-label. The combination…

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Explore the main themes, entities and connections around Naltrexone. Start with the topic map, then use the sections below for research and deeper semantic analysis.

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Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
N07BB04 (WHO)
Bioavailability
5–60%
CAS Number
16590-41-3 Y
ChEBI
CHEBI:7465 Y

Topics to explore

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Overview

Medical uses

Side effects

Overdose

Chemistry

History

Society and culture

Research

Veterinary use

Advanced semantic analysis

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Map overview Semantic statistics

Naltrexone

Nodes236
Edges235
Triples219
Avg. degree1.99
Density0.008475
Components1

How this topic connects Entity context

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Naltrexone

Top relations

related to Controversies · 26
Naltrexone → Alkermes, Bekhterev Research Psychoneurological Institute, Boston-based, Congressional, Critics, Despite, Evgeny Krupitsky, FDA, Further, In, July, Many, Medical University, Nearly, Norway, October, Russia, St Petersburg, St Petersburg State Pavlov, Subsequent
related to history · 17
Naltrexone → Blumberg, Clinical, Dayton, Drug Abuse, DuPont, EN-1639A, Endo Laboratories, FDA, It, Metossian, National Institute, New York City, Revia, The, Trexan, Vivitrol, Wolf
related to Brand names · 16
Naltrexone → Adepend, Antaxone, Celupan, Contrave, Depade, Destoxican, Embeda, It, Nalorex, Narcoral, Nemexin, Nodict, Revia, Trexan, Vivitrex, Vivitrol
related to Others · 13
Naltrexone → Although, As, Case, Chantix, COVID, In, LDN, ME/CFS, October, Reports, The, Unlike, When
has effect · 11
Naltrexone → According, Another, Based, For, However, In, It, Most, The, These, Whether
related to Analogues · 8
Naltrexone → N-allylnorcodeine, N-allylnormorphine, N-allylnoroxymorphone, N-cyclobutylmethyl-14-hydroxydihydronormorphine, N-methylnaltrexone, Nalmefene, Other, The
related to Generic names · 8
Naltrexone → BANMTooltip British Approved Name, BANTooltip British Approved Name, DCFTooltip Dénomination Commune Française, DCITTooltip Denominazione Comune Italiana, INNTooltip International Nonproprietary Name, Name, USANTooltip United States Adopted, USPTooltip United States Pharmacopeia
related to Opioid use disorder · 8
Naltrexone → Among, In, Injection, It, Long-acting, OUD, Unlike, Vivitrol
related to Alcohol use disorder · 7
Naltrexone → Acamprosate, AUD, In, Its, John David Sinclair, Sinclair Method, Studies
Legal status · 6
Naltrexone → AU: S4 (Prescription only), BR: Class C1 (Other controlled substances), CA: ℞-only, In general: ℞ (Prescription only), UK: POM (Prescription only), US: ℞-only

Important terminology Word statistics

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Important terminology

opioid effects studies may use opioids oral 6β-naltrexol buprenorphine alcohol mg treatment used brain administration antagonist dependence mor also withdrawal

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Naltrexone3D model (JSmol)Interactive image1.00infobox
NaltrexoneAHFS/Drugs.comMonograph1.00infobox
NaltrexoneATC codeN07BB04 (WHO)1.00infobox
NaltrexoneBioavailability5–60%1.00infobox
NaltrexoneCAS Number16590-41-3 Y1.00infobox
NaltrexoneChEBICHEBI:7465 Y1.00infobox
NaltrexoneChEMBLChEMBL19019 Y1.00infobox
NaltrexoneChemSpider4514524 Y1.00infobox
NaltrexoneCompTox Dashboard (EPA)DTXSID40463131.00infobox
NaltrexoneDrugBankDB00704 Y1.00infobox
NaltrexoneDuration of action>72 hours1.00infobox
NaltrexoneECHA InfoCard100.036.9391.00infobox
NaltrexoneElimination half-lifeOral (Revia): • Naltrexone: 4 hours • 6β-Naltrexol: 13 hours Oral (Contrave): • Naltrexone: 5 hours IMTooltip Intramuscular injection (Vivitrol): • Naltrexone: 5–10 days • 6β-Na…1.00infobox
NaltrexoneExcretionUrine1.00infobox
NaltrexoneFormulaC20H23NO41.00infobox
NaltrexoneIUPHAR/BPS16391.00infobox
NaltrexoneKEGGD05113 Y1.00infobox
NaltrexoneLegal statusAU: S4 (Prescription only)1.00infobox
NaltrexoneLegal statusBR: Class C1 (Other controlled substances)1.00infobox
NaltrexoneLegal statusCA: ℞-only1.00infobox
NaltrexoneLegal statusUK: POM (Prescription only)1.00infobox
NaltrexoneLegal statusUS: ℞-only1.00infobox
NaltrexoneLegal statusIn general: ℞ (Prescription only)1.00infobox
NaltrexoneLicense dataUS DailyMed: Naltrexone1.00infobox
NaltrexoneMedlinePlusa6850411.00infobox
NaltrexoneMelting point169 °C (336 °F)1.00infobox
NaltrexoneMetabolismLiver (non-CYP450)1.00infobox
NaltrexoneMetabolites6β-Naltrexol, others1.00infobox
NaltrexoneMolar mass341.407 g·mol−11.00infobox
NaltrexoneOnset of action30 minutes1.00infobox

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