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Lonafarnib

Lonafarnib, sold under the brand name Zokinvy, is a medication used to reduce the risk of death due to Hutchinson-Gilford progeria syndrome and for the treatment of certain processing-deficient progeroid laminopathies in people one year of age and older. It is under trial for its use as combination treatment for Hepatitis D Virus.

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3D model (JSmol)
Interactive image
ATC code
A16AX20 (WHO)
CAS Number
193275-84-2 N
ChEBI
CHEBI:47097 N
ChEMBL
ChEMBL298734 Y
ChemSpider
130645 Y

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Map overview Semantic statistics

Lonafarnib

Nodes50
Edges49
Triples85
Avg. degree1.96
Density0.04
Components1

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Lonafarnib

Top relations

related to External links · 20
Lonafarnib → Archived, ClinicalTrials, Drug Information Portal, Experimental Drug Is First, Farnesyltransferase Inhibitor, March, Medicine, National Library, NCT00425607, NCT00916747, NPR, Patients With Progeria, Phase II Trial, Pravastatin, Premature-Aging Disease, Progeria, September, Study, To Help Kids With, Zoledronic Acid
related to Cancer · 17
Lonafarnib → Below, Co, FDA-approved, FTase, HDV, HGPS, However, Hutchinson-Gilford, It, Merck, Originally, Ras, Ras-driven, RhoB, SCH, This, Zokinvy
related to history · 13
Lonafarnib → Drug Administration, Eiger BioPharmaceuticals, FDA, Food, Gilford, Hutchinson, In, Inc, Its, Lonafarnib's, The, The FDA, Zokinvy
related to Research · 4
Lonafarnib → As, For, FTI, II
related to Hepatitis D · 3
Lonafarnib → HDV, Ongoing, Up
Legal status · 2
Lonafarnib → EU: Rx-only, US: ℞-only
3D model (JSmol) · 1
Lonafarnib → Interactive image
ATC code · 1
Lonafarnib → A16AX20 (WHO)
CAS Number · 1
Lonafarnib → 193275-84-2 N
ChEBI · 1
Lonafarnib → CHEBI:47097 N

Important terminology Word statistics

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Important terminology

cancer treatment progeria phase clinical trials data patients drug use efficacy progeroid due certain trial medication zokinvy laminopathies hepatitis farnesyltransferase

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Lonafarnib3D model (JSmol)Interactive image1.00infobox
LonafarnibATC codeA16AX20 (WHO)1.00infobox
LonafarnibCAS Number193275-84-2 N1.00infobox
LonafarnibChEBICHEBI:47097 N1.00infobox
LonafarnibChEMBLChEMBL298734 Y1.00infobox
LonafarnibChemSpider130645 Y1.00infobox
LonafarnibCompTox Dashboard (EPA)DTXSID901729271.00infobox
LonafarnibDrugBankDB064481.00infobox
LonafarnibECHA InfoCard100.204.5091.00infobox
LonafarnibFormulaC27H31Br2ClN4O21.00infobox
LonafarnibIUPHAR/BPS80241.00infobox
LonafarnibKEGGD04768 Y1.00infobox
LonafarnibLegal statusUS: ℞-only1.00infobox
LonafarnibLegal statusEU: Rx-only1.00infobox
LonafarnibLicense dataUS DailyMed: Lonafarnib1.00infobox
LonafarnibMolar mass638.83 g·mol−11.00infobox
LonafarnibOther namesSCH 663361.00infobox
LonafarnibPDB ligand336 (PDBe, RCSB PDB)1.00infobox
LonafarnibPubChem CID1481951.00infobox
LonafarnibRoutes of administrationBy mouth1.00infobox
LonafarnibTrade namesZokinvy1.00infobox
LonafarnibUNIIIOW153004F1.00infobox
Lonafarnibis asynthetic tricyclic halogenated carboxamide with antineoplastic properties0.90text

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