Lonafarnib, sold under the brand name Zokinvy, is a medication used to reduce the risk of death due to Hutchinson-Gilford progeria syndrome and for the treatment of certain processing-deficient progeroid laminopathies in people one year of age and older. It is under trial for its use as combination treatment for Hepatitis D Virus.
Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.
More settings
Lonafarnib topic overview
The analysis highlights History, Community, Culture and Applications as prominent areas in the source structure around Lonafarnib.
Related topics
44
Source areas
5
Connected nodes
49
Extracted relationships
85
Concept neighborhoods
16
Bridge connections
49
What this topic covers Research coverage
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Overview · 22 topics
Research · 15 topics
History · 4 topics
Society and culture · 2 topics
Medical uses · 1 topics
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
Key facts & relationships
High-confidence facts extracted from structured source data. Use them as anchors for further research.
3D model (JSmol)
Interactive image
ATC code
A16AX20 (WHO)
CAS Number
193275-84-2 N
ChEBI
CHEBI:47097 N
ChEMBL
ChEMBL298734 Y
ChemSpider
130645 Y
Explore all related topics Closing gaps
A structured outline of related entities, concepts and subtopics. Open any item to build a new map centered on it.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
How Lonafarnib connects Entity context
Entity context groups extracted connections by relationship type. Counts show recurrence in the analyzed source; the examples are research signals, not claims about importance.
The extracted context around Lonafarnib shows recurring relationship patterns in the source. For example, Lonafarnib → Archived, ClinicalTrials, Drug Information Portal, Experimental Drug Is First, Farnesyltransferase Inhibitor, March, Medicine, National Library, NCT00425607, NCT00916747, NPR, Patients With Progeria, Phase II Trial, Pravastatin, Premature-Aging Disease, Progeria, September, Study, To Help Kids With, Zoledronic Acid Another extracted example is Lonafarnib → Below, Co, FDA-approved, FTase, HDV, HGPS, However, Hutchinson-Gilford, It, Merck, Originally, Ras, Ras-driven, RhoB, SCH, This, Zokinvy. Use these groups to spot repeated connection types before inspecting the individual relationships.
Lonafarnib
Top relations
related to External links· 20
Lonafarnib → Archived, ClinicalTrials, Drug Information Portal, Experimental Drug Is First, Farnesyltransferase Inhibitor, March, Medicine, National Library, NCT00425607, NCT00916747, NPR, Patients With Progeria, Phase II Trial, Pravastatin, Premature-Aging Disease, Progeria, September, Study, To Help Kids With, Zoledronic Acid
Relationships are represented as Subject → Predicate → Object triples. Confidence describes extraction strength, not the real-world importance of a relationship; lower-confidence rows may be contextual rather than explicit.
TTTA extracted 85 structured relationships around Lonafarnib. Examples in this analysis include Lonafarnib → 3D model (JSmol) → Interactive image and Lonafarnib → ATC code → A16AX20 (WHO). The table shows each extracted connection, where it came from and its confidence.
Subject
Predicate
Object
Confidence
Src
Lonafarnib
3D model (JSmol)
Interactive image
1.00
infobox
Lonafarnib
ATC code
A16AX20 (WHO)
1.00
infobox
Lonafarnib
CAS Number
193275-84-2 N
1.00
infobox
Lonafarnib
ChEBI
CHEBI:47097 N
1.00
infobox
Lonafarnib
ChEMBL
ChEMBL298734 Y
1.00
infobox
Lonafarnib
ChemSpider
130645 Y
1.00
infobox
Lonafarnib
CompTox Dashboard (EPA)
DTXSID90172927
1.00
infobox
Lonafarnib
DrugBank
DB06448
1.00
infobox
Lonafarnib
ECHA InfoCard
100.204.509
1.00
infobox
Lonafarnib
Formula
C27H31Br2ClN4O2
1.00
infobox
Lonafarnib
IUPHAR/BPS
8024
1.00
infobox
Lonafarnib
KEGG
D04768 Y
1.00
infobox
Lonafarnib
Legal status
US: ℞-only
1.00
infobox
Lonafarnib
Legal status
EU: Rx-only
1.00
infobox
Lonafarnib
License data
US DailyMed: Lonafarnib
1.00
infobox
Lonafarnib
Molar mass
638.83 g·mol−1
1.00
infobox
Lonafarnib
Other names
SCH 66336
1.00
infobox
Lonafarnib
PDB ligand
336 (PDBe, RCSB PDB)
1.00
infobox
Lonafarnib
PubChem CID
148195
1.00
infobox
Lonafarnib
Routes of administration
By mouth
1.00
infobox
Lonafarnib
Trade names
Zokinvy
1.00
infobox
Lonafarnib
UNII
IOW153004F
1.00
infobox
Lonafarnib
is a
synthetic tricyclic halogenated carboxamide with antineoplastic properties
0.90
text
No triples extracted yet.
Related concept clusters Concept neighborhoods
Concept neighborhoods group terms that sit near one another in the extracted graph. They are useful for discovering adjacent language and context, but proximity does not by itself imply a factual relationship.
The concept neighborhoods around Lonafarnib bring nearby vocabulary together. In this analysis, examples include Progeria, Clinical and Treatment. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
Lonafarnib
Progeria
Clinical
Treatment
Farnesyltransferase
Inhibitor
Trial
Trials
Age
Phase
Hdv
Used
Showed
lonafarnib
Progeria
Clinical
Treatment
Farnesyltransferase
Inhibitor
Trial
Trials
Age
Phase
Hdv
Used
Showed
hutchinson-gilford progeria syndrome
Laminopathies
Syndrome
Progeroid
Zokinvy
Age
Certain
Processing-deficient
Hepatitis
Used
Clinical
Progeria
Status
food and drug administration
Drug
Status
Medication
Age
Hutchinson-gilford
Medical
Processing-deficient
Hepatitis
Laminopathies
Syndrome
Used
Progeria
non-small cell lung cancer
Lung
Phase
Survival
Data
Due
Showed
Trials
Used
Efficacy
Clinical
Status
Treatment
hutchinson-gilford progeria
Laminopathies
Syndrome
Progeroid
Zokinvy
Age
Certain
Processing-deficient
Hepatitis
Used
Clinical
Progeria
Status
hepatitis d
Hutchinson-gilford
Hdv
Laminopathies
Syndrome
Progeroid
Zokinvy
Treatment
Status
Progeria
Administration
Clinical
Medical
laminopathies
Progeroid
Processing-deficient
Syndrome
Zokinvy
Age
Hepatitis
Used
Progeria
Treatment
Status
Data
Administration
Connections between topic areas Semantic bridges
Semantic bridges connect parts of the graph that would otherwise be more separate. A bridge is a structural signal in this analysis, not a claim that the two topic areas are equivalent.
For Lonafarnib, one of the stronger structural bridges in this analysis connects Lonafarnib with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
Number of nodes, edges, triples, density and central hubs. Use it to gauge the size and connectivity of the map.
Lonafarnib
Nodes50
Edges49
Triples85
Avg. degree1.96
Density0.04
Components1
Source & methodology
TTTA analyzes the structure around Lonafarnib to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Community, Culture & Applications, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
