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DNA ligase 1

DNA ligase 1 also DNA ligase I, is an enzyme that in humans is encoded by the LIG1 gene. DNA ligase 1 is the only known eukaryotic DNA ligase involved in both DNA replication and repair, making it the most studied of the ligases.

Recruitment and regulation, Function and mechanism & Role in damaged base repair

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6.5.1.1
Aliases
LIG1, DNA ligase 1, LIGI, hLig1, IMD96
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1X9N
Band
19q13.33 · 7 A1|7 7.82 cM
Bgee
right uterine tube · ventricular zone · ganglionic eminence · sural nerve · mucosa of transverse colon
BioGPS
More reference expression data

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Overview

Discovery

Recruitment and regulation

Function and mechanism

Role in damaged base repair

Clinical significance

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DNA ligase 1

Nodes58
Edges57
Triples176
Avg. degree1.97
Density0.034483
Components1

How this topic connects Entity context

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DNA ligase 1

Top relations

related to Recruitment and regulation · 33
DNA ligase 1 → Activation, Although, Both, C-terminal, C-terminus, CDK, CKII, Cy, DBD, DNA, II, LIG1, Moreover, N-terminal, N-terminal DNA, N-terminus, NLS, NTase, OB, PCNA
Gene ontology · 29
DNA ligase 1 → anatomical structure morphogenesis, ATP binding, base-excision repair, cell cycle, cell division, cellular response to DNA damage stimulus, cytoplasm, DNA binding, DNA biosynthetic process, DNA ligase (ATP) activity, DNA ligase activity, DNA ligation, DNA ligation involved in DNA repair, DNA mismatch repair, DNA recombination, DNA repair, DNA replication, intracellular membrane-bounded organelle, lagging strand elongation, ligase activity
Bgee · 20
DNA ligase 1 → epiblast, fetal liver hematopoietic progenitor cell, ganglionic eminence, genital tubercle, gonad, granulocyte, inner renal medulla, left testis, maxillary prominence, mucosa of transverse colon, outer renal medulla, primitive streak, right testis, right uterine tube, somite, sural nerve, tail of embryo, testicle, ventricular zone, yolk sac
RNA expression pattern · 20
DNA ligase 1 → epiblast, fetal liver hematopoietic progenitor cell, ganglionic eminence, genital tubercle, gonad, granulocyte, inner renal medulla, left testis, maxillary prominence, mucosa of transverse colon, outer renal medulla, primitive streak, right testis, right uterine tube, somite, sural nerve, tail of embryo, testicle, ventricular zone, yolk sac
related to Role in damaged base repair · 17
DNA ligase 1 → AP, AP-endonuclease, BER, DNA, DNA Polymerase, First, III, In, In LP-BER, It, Ligase, LP-BER, N-glycosidic, SN-BER, SNBER, The, This
related to Clinical significance · 11
DNA ligase 1 → Chemical, Clinical, Defects, DNA, DNA-damaging, LIG1, Molecular, Mutations, Notably, The, There
related to Function and mechanism · 11
DNA ligase 1 → ATP, DNA, DNA's, During, Eukaryotic DNA, If, In, LIG1, Okazaki, RNA, S-phase
related to External links · 6
DNA ligase 1 → DNA, Overview, P18858, PDB, PDBe-KB, UniProt
Band · 2
DNA ligase 1 → 19q13.33, 7 A1|7 7.82 cM
Chr. · 2
DNA ligase 1 → Chromosome 19 (human), Chromosome 7 (mouse)

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Important terminology

dna ligase repair replication bp lig1 human cell chr band known enzyme gene n-terminal nick chromosome 19 strand immunodeficiency catalytic

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
DNA ligase 16.5.1.11.00infobox
DNA ligase 1AliasesLIG1, DNA ligase 1, LIGI, hLig1, IMD961.00infobox
DNA ligase 1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1X9N1.00infobox
DNA ligase 1Band19q13.331.00infobox
DNA ligase 1Band7 A1|7 7.82 cM1.00infobox
DNA ligase 1Bgeeright uterine tube1.00infobox
DNA ligase 1Bgeeventricular zone1.00infobox
DNA ligase 1Bgeeganglionic eminence1.00infobox
DNA ligase 1Bgeesural nerve1.00infobox
DNA ligase 1Bgeemucosa of transverse colon1.00infobox
DNA ligase 1Bgeeleft testis1.00infobox
DNA ligase 1Bgeegranulocyte1.00infobox
DNA ligase 1Bgeegonad1.00infobox
DNA ligase 1Bgeeright testis1.00infobox
DNA ligase 1Bgeetesticle1.00infobox
DNA ligase 1Bgeetail of embryo1.00infobox
DNA ligase 1Bgeegenital tubercle1.00infobox
DNA ligase 1Bgeeouter renal medulla1.00infobox
DNA ligase 1Bgeefetal liver hematopoietic progenitor cell1.00infobox
DNA ligase 1Bgeeinner renal medulla1.00infobox
DNA ligase 1Bgeeprimitive streak1.00infobox
DNA ligase 1Bgeeepiblast1.00infobox
DNA ligase 1Bgeesomite1.00infobox
DNA ligase 1Bgeeyolk sac1.00infobox
DNA ligase 1Bgeemaxillary prominence1.00infobox
DNA ligase 1BioGPSMore reference expression data1.00infobox
DNA ligase 1Chr.Chromosome 19 (human)1.00infobox
DNA ligase 1Chr.Chromosome 7 (mouse)1.00infobox
DNA ligase 1DatabasesNCBI: entry; OMA: entry1.00infobox
DNA ligase 1End48,170,603 bp1.00infobox

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