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LexA repressor

The LexA repressor or LexA (Locus for X-ray sensitivity A) is a transcriptional repressor (EC 3.4.21.88) that represses SOS response genes coding primarily for error-prone DNA polymerases, DNA repair enzymes and cell division inhibitors. LexA forms de facto a two-component regulatory system with RecA, which senses DNA damage at stalled replication forks…

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Key facts & relationships

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AlphaFold
IPR006199 · PF01726
Available protein structures:
IPR006199 · PF01726
InterPro
IPR006199
PDB
IPR006199 PF01726 (ECOD; PDBsum)
Pfam
PF01726
Pfam clan
CL0123

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Overview

Clinical significance

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Map overview Semantic statistics

LexA repressor

Nodes33
Edges32
Triples12
Avg. degree1.94
Density0.060606
Components1

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LexA repressor

Top relations

AlphaFold · 2
LexA repressor → IPR006199, PF01726
Available protein structures: · 2
LexA repressor → IPR006199, PF01726
InterPro · 1
LexA repressor → IPR006199
PDB · 1
LexA repressor → IPR006199 PF01726 (ECOD; PDBsum)
Pfam · 1
LexA repressor → PF01726
Pfam clan · 1
LexA repressor → CL0123
SCOP2 · 1
LexA repressor → 1leb / SCOPe / SUPFAM
Symbol · 1
LexA repressor → LexA_DNA_bind

Important terminology Word statistics

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Important terminology

dna lexa sos response domain ciprofloxacin bacteria antibiotics damage autoproteolysis dimerization replication genes binding polypeptides dna-binding form protein reca action

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
LexA repressorAlphaFoldIPR0061991.00infobox
LexA repressorAlphaFoldPF017261.00infobox
LexA repressorAvailable protein structures:IPR0061991.00infobox
LexA repressorAvailable protein structures:PF017261.00infobox
LexA repressorInterProIPR0061991.00infobox
LexA repressorPDBIPR006199 PF01726 (ECOD; PDBsum)1.00infobox
LexA repressorPfamPF017261.00infobox
LexA repressorPfam clanCL01231.00infobox
LexA repressorSCOP21leb / SCOPe / SUPFAM1.00infobox
LexA repressorSymbolLexA_DNA_bind1.00infobox
DNA gyrase or topoisomerase IV for DNA replicationinstance ofBacteria require topoisomerases0.80text
ciprofloxacin are able to prevent the action of these molecules by attaching themselves to the gyrateinstance ofAntibiotics0.80text

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    Min side: 3
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