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Leaving group

In organic chemistry, a leaving group typically means a molecular fragment that departs with an electron pair during a reaction step with heterolytic bond cleavage. In this usage, a leaving group is a less formal but more commonly used synonym of the term nucleofuge; although IUPAC gives the term a broader definition.

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Overview

Nomenclature

SN2 reactions

Base eliminations

Activation

Spontaneous departure

Advanced semantic analysis

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Map overview Semantic statistics

Leaving group

Nodes73
Edges72
Triples65
Avg. degree1.97
Density0.027397
Components1

How this topic connects Entity context

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Leaving group

Top relations

related to SN2 reactions · 15
Leaving group → Br, Cl, E2, EtS, For SN2, H2O, Hydroxide, OAr, OMs, OTf, OTs, Ph2P, Phenoxides, Phosphate, SN2
related to Activation · 8
Leaving group → E1, For, Friedel-Crafts, In SN1, Lewis, The, Then, There
related to Nomenclature · 8
Leaving group → CO2, In, IUPAC, Leaving, N2, Similarly, SiR, The
related to Context-dependence · 7
Leaving group → For, In, In SNAr, Leaving, Meisenheimer, The, This
related to E1cb reactions · 7
Leaving group → AB, BC, E1cb, E2, Eventually, First, Poor
related to overview · 6
Leaving group → Because, E1, Equivalently, For, Leaving, SN1
related to Spontaneous departure · 6
Leaving group → Any, Conversely, Even, Lewis, Prominent, Thus
related to Base eliminations · 5
Leaving group → For, Many E1cb, R2N, This, When
is a · 1
Leaving group → less formal but more commonly used synonym of the term nucleofuge

Important terminology Word statistics

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Important terminology

leaving group groups reaction reactions ability transition poor acid elimination step bond energy needed commonly electron state citation organic rate

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Leaving groupis aless formal but more commonly used synonym of the term nucleofuge0.90text
tosylateinstance ofhalides and sulfonate esters0.80text
OHinstance ofStrong bases0.80text
Leaving grouprelated to ActivationIn SN10.60section
Leaving grouprelated to ActivationE10.60section
Leaving grouprelated to ActivationLewis0.60section
Leaving grouprelated to ActivationThen0.60section
Leaving grouprelated to ActivationFor0.60section
Leaving grouprelated to ActivationThe0.60section
Leaving grouprelated to ActivationFriedel-Crafts0.60section
Leaving grouprelated to ActivationThere0.60section
Leaving grouprelated to Base eliminationsWhen0.60section

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