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Β-Lactam antibiotic

β-Lactam antibiotics (beta-lactam antibiotics) are antibiotics that contain a β-lactam ring in their chemical structure. This includes penicillin derivatives (penams), cephalosporins and cephamycins (cephems), monobactams, carbapenems and carbacephems. Most β-lactam antibiotics work by inhibiting cell wall biosynthesis in the bacterial organism and are…

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ATC code
J01C
Biological target
Penicillin binding protein
MeSH
D047090
Use
Bacterial infection

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Overview

Medical use

Adverse effects

Mechanism of action

Potency

Modes of resistance

Nomenclature

Biosynthesis

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Map overview Semantic statistics

Β-Lactam antibiotic

Nodes114
Edges113
Triples60
Avg. degree1.98
Density0.017544
Components1

How this topic connects Entity context

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Β-Lactam antibiotic

Top relations

related to Enzymatic hydrolysis of the β-lactam ring · 10
Β-Lactam antibiotic → An, Another, Augmentin, Extended-Spectrum, FGP, For, If, In, New Delhi, The
related to Inhibition of cell wall synthesis · 9
Β-Lactam antibiotic → DD-transpeptidases, In, Lactam, NAM/NAG-peptide, PBP, PBPs, Ser62, The, This
related to Possession of altered penicillin-binding proteins · 8
Β-Lactam antibiotic → Altered PBPs, As, Lactam, MRSA, Notable, PBPs, Staphylococcus, Streptococcus
related to Potency · 7
Β-Lactam antibiotic → Cohen's, PBP, PBPs, The, This, Two, Woodward's
related to Allergy/hypersensitivity · 6
Β-Lactam antibiotic → Anaphylaxis, IgE-mediated, Immunologically, Nevertheless, Rarely, There
related to Medical use · 4
Β-Lactam antibiotic → At, AUCCSF/AUCS, In, Lactam
related to Modes of resistance · 4
Β-Lactam antibiotic → By, Hence, PBP, The
see also · 3
Β-Lactam antibiotic → J01C Beta-lactam, J01D Other, List
related to Adverse drug reactions · 2
Β-Lactam antibiotic → Common, Infrequent
ATC code · 1
Β-Lactam antibiotic → J01C

Important terminology Word statistics

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Important terminology

β-lactam antibiotics ring β-lactamase β-lactams bacterial named rings antibiotic bacteria resistance penams cephems carbapenems penicillin containing cephalosporins cell peptidoglycan wall

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Β-Lactam antibioticATC codeJ01C1.00infobox
Β-Lactam antibioticBiological targetPenicillin binding protein1.00infobox
Β-Lactam antibioticMeSHD0470901.00infobox
Β-Lactam antibioticUseBacterial infection1.00infobox
clavulanic acidinstance ofβ-lactam antibiotics can be given with β-lactamase inhibitors0.80text
syphilis with a β-lactam antibioticinstance ofHerxheimer reaction may occur after initial treatment of a spirochetal infection0.80text
boronic acids are being studied in which they irreversibly bind to the active site of β-lactamasesinstance ofThe addition of tazobactam to piperacillin has enhanced its stability against a wide range of β-lactamase enzymes including some Extended-Spectrum β-lactamases.Other β-lactamase…0.80text
Β-Lactam antibioticrelated to Adverse drug reactionsCommon0.60section
Β-Lactam antibioticrelated to Adverse drug reactionsInfrequent0.60section
Β-Lactam antibioticrelated to Allergy/hypersensitivityImmunologically0.60section
Β-Lactam antibioticrelated to Allergy/hypersensitivityIgE-mediated0.60section
Β-Lactam antibioticrelated to Allergy/hypersensitivityAnaphylaxis0.60section

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